Augmented Reality Platform for Deep Brain Stimulation

用于深部脑刺激的增强现实平台

• 批准号: 10533405
• 负责人: Cameron McIntyre
• 金额: $ 38.13万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10533405
• 关键词: 3-Dimensional; Algorithms; Anatomy; Atlases; Augmented Reality; Axon; Basal Ganglia; Biological Models; Biomedical Engineering; Clinical; Collection; Complex; Computer software; Computers; Coupled; Data; Data Set; Deep Brain Stimulation; Development; Diffusion Magnetic Resonance Imaging; Educational process of instructing; Electrodes; Environment; Focus Groups; Future; Goals; Guidelines; Human; Investigation; Knowledge; Link; Literature; Magnetic Resonance Imaging; Medial lemniscus; Methodology; Mind; Modeling; Neuroanatomy; Neurosurgeon; Operative Surgical Procedures; Outcome; Parkinson Disease; Pathway interactions; Patient imaging; Patients; Positioning Attribute; Pyramidal Tracts; Quality of life; Research; Research Project Grants; Software Tools; Symptoms; System; Techniques; Technology; Testing; Three-Dimensional Imaging; Training; Translating; United States National Institutes of Health; Visualization software; Work; anatomical tracing; clinical practice; education research; hologram; holographic visualization; improved; insight; motor symptom; next generation; novel; rapid growth; reconstruction; simulation; targeted treatment; tool; tractography; virtual

PROJECT SUMMARY Subthalamic deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD) can be highly effective at improving motor symptoms and enhancing the patient's quality of life. However, the specific details of the anatomical target(s) for therapeutic stimulation remain unresolved. Recent DBS surgical targeting hypotheses have evolved to consider that direct stimulation of specific axonal pathways within the subthalamic region may be linked to the control of specific symptoms. Unfortunately, 3D anatomical characterization of the wide array of different axonal pathways in the human subthalamic region is very limited and techniques to visualize the complex neuroanatomy currently focus on 2D computer screens. These limitations hinder our ability to create accurate models and interpret the effects of DBS. Therefore, we propose that significant need exists for an anatomically driven model of subthalamic axonal pathways that can be interactively visualized with holographic 3D imaging and coupled to patient-specific DBS simulations. The goal of this Bioengineering Research Grant (PAR-16-242) is to create next generation visualization tools and surgical targeting models for clinical DBS. The first step of this study will rely on direct input from a collection of world experts in basal ganglia neuroanatomy to help us build a virtual 3D atlas model of 8 different axonal pathways in the subthalamic region. This development will occur within the HoloLens augmented reality (AR) environment, thereby enabling face-to-face discussion among the anatomy experts while visualizing the model hologram and its interactive adjustment. The second step of this study will evaluate the ability of various tractography algorithms to recreate the pathways described by the anatomy experts. We hypothesize that tractography will fail to accurately capture the anatomical trajectory of most subthalamic axonal pathways without extensive modeling constraints. Results from this analysis will have important implications for the rapid growth of tractography in DBS research, as well as clinical practice. Finally, we will translate our subthalamic axonal pathway model system into an interactive HoloLens AR application that works in concert with patient-specific MRI datasets and DBS pathway-activation modeling. We propose that such a tool will be especially useful for DBS surgical education and research investigation.

项目摘要 丘脑深脑刺激（DBS）用于治疗帕金森氏病（PD） 有效改善运动症状并提高患者的生活质量。但是，具体细节 用于治疗刺激的解剖靶标仍未解决。最近的DBS手术靶向 假设已经演变为考虑到丘脑下丘脑内特定轴突途径的直接刺激 区域可能与特定症状的控制有关。不幸的是，3D解剖学表征 人类亚丘脑区域中各种不同的轴突途径非常有限，技术到 可视化复杂的神经解剖学目前专注于2D计算机屏幕。这些限制阻碍了我们 能够创建准确的模型并解释DBS的效果。因此，我们提出了重大需求 存在于丘脑轴突下途径的解剖学驱动模型的存在 带有全息3D成像，并与患者特异性DBS模拟耦合。 这项生物工程研究补助金（PAR-16-242）的目标是创建下一代可视化 临床DBS的工具和手术靶向模型。这项研究的第一步将依赖于 基础神经节神经解剖学的世界专家收集，以帮助我们建立一个虚拟的3D地图集模型 丘脑下区域的轴突途径。这种发展将发生在Hololens的增强中 现实（AR）环境，从而在解剖专家之间进行面对面的讨论 可视化模型全息图及其交互调整。这项研究的第二步将评估 各种拖拉算法的能力重新创建解剖学专家描述的途径。我们 假设拖拉学将无法准确捕获大多数亚丘脑的解剖轨迹 没有广泛建模约束的轴突途径。该分析的结果将具有重要的 对DBS研究中拖拉术快速增长的影响以及临床实践。最后，我们会的 将我们的丘脑轴突途径模型系统转换为有效的交互式HoloLens AR应用 与患者特异性的MRI数据集和DBS途径激活建模。我们建议这样的 工具对于DBS手术教育和研究调查特别有用。

项目成果

Stereo-EEG-guided network modulation for psychiatric disorders: Surgical considerations.

• DOI: 10.1016/j.brs.2023.07.057
• 发表时间: 2023-11
• 期刊: BRAIN STIMULATION
• 影响因子: 7.7
• 作者: Sheth, Sameer A.;Shofty, Ben;Allawala, Anusha;Xiao, Jiayang;Adkinson, Joshua A.;Mathura, Raissa K.;Pirtle, Victoria;Myers, John;Oswalt, Denise;Provenza, Nicole R.;Giridharan, Nisha;Noecker, Angela M.;Banks, Garrett P.;Gadot, Ron;Najera, Ricardo A.;Anand, Adrish;Devara, Ethan;Dang, Huy;Bartoli, Eleonora;Watrous, Andrew;Cohn, Jeffrey;Borton, David;Mathew, Sanjay J.;Mcintyre, Cameron C.;Goodman, Wayne;Bijanki, Kelly;Pouratian, Nader
• 通讯作者: Pouratian, Nader

Stereo-EEG-guided network modulation for psychiatric disorders: Interactive holographic planning.

• DOI: 10.1016/j.brs.2023.11.003
• 发表时间: 2023-11
• 期刊: BRAIN STIMULATION
• 影响因子: 7.7
• 作者: Noecker, Angela M.;Mlakar, Jeffrey;Bijanki, Kelly R.;Griswold, Mark A.;Pouratian, Nader;Sheth, Sameer A.;Mcintyre, Cameron C.
• 通讯作者: Mcintyre, Cameron C.

StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.

• DOI: 10.1111/ner.13350
• 发表时间: 2021-03
• 期刊: Neuromodulation : journal of the International Neuromodulation Society
• 作者: Noecker AM;Frankemolle-Gilbert AM;Howell B;Petersen MV;Beylergil SB;Shaikh AG;McIntyre CC
• 通讯作者: McIntyre CC

Deep Brain Stimulation for Depression Informed by Intracranial Recordings.

• DOI: 10.1016/j.biopsych.2021.11.007
• 发表时间: 2022-08-01
• 期刊: Biological psychiatry
• 影响因子: 10.6

Histology-driven model of the macaque motor hyperdirect pathway.

• DOI: 10.1007/s00429-021-02307-7
• 发表时间: 2021-09
• 期刊: Brain structure & function
• 影响因子: 3.1
• 作者: Bingham CS;Parent M;McIntyre CC
• 通讯作者: McIntyre CC