RR&D Gordon Mansfield Spinal Cord Injury Consortium

基本信息

批准号：
10538563
负责人：
MARK H. TUSZYNSKI
金额：
--
依托单位：
VA SAN DIEGO HEALTHCARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10538563
关键词：
Anatomy Axon Bilateral Biodistribution Brain California Cells Central Nervous System Cervical spinal cord injury Cervical spinal cord structure Chronic Clinical Clinical Trials Collaborations Combined Modality Therapy Contusions Data Development ES Cell Line Forelimb Funding Graft Survival Grant Human Human Cell Line Injury Intervention Investigational Therapies Investments Laboratories Lead Lesion Life Lower Extremity Macaca mulatta Measures Mediating Medical center Modeling Monkeys Natural regeneration Neuronal Plasticity Neurons Outcome Pain Pathologist Persons Primates Rattus Readiness Recovery Recovery of Function Rehabilitation device Rehabilitation therapy Reproducibility Research Research Personnel Robotics Rodent Safety Sampling San Francisco Scientist Site Spinal Spinal Cord Spinal Cord Contusions Spinal cord injury Synapses Technology Toxic effect Training Translating Translations Upper Extremity Validation Vertebral column Veterans Work axon regeneration axonal sprouting clinically relevant design effective therapy efficacy study efficacy testing experimental study functional improvement functional outcomes grasp hand rehabilitation human embryonic stem cell human embryonic stem cell line improved in vivo evaluation injury and repair innovation lead candidate nerve stem cell neural neural circuit neurological recovery neuroregulation nonhuman primate operation programs rehabilitation paradigm rehabilitation strategy repaired safety study skills spasticity stem cell biology stem cell survival stem cell therapy stem cells synaptogenesis synergism therapy development

项目摘要

This project aims to develop a neural stem cell (NSC) therapy to repair the injured spinal cord and support functional recovery. In the proposed work, we aim to advance this program to an IND-enabling stage. Moreover, we aim to continue to develop and optimize potential stem cell therapies for spinal cord injury (SCI) by examining combinations of innovative rehabilitation and spinal cord neuromodulation strategies with neural stem cell therapies to potentially amplify stem cell-mediated recovery of function. Finally, we aim to invest substantial effort to assess NSC efficacy in chronic SCI. This work focuses on human NSCs derived from a federally “approved” human embryonic stem cell (ESC) line, the H9 ESC line. The studies we propose herein will primarily use clinically relevant spinal cord injury contusion models. Independent replication by an investigator outside this consortium of scientists will be conducted. Notably, this is an intensely collaborative effort among leading laboratories researching spinal cord injury, including the Tuszynski group at the San Diego VA Medical Center and UCSD (includes Drs. Rosenzweig, Lu and Brock); the Beattie/Bresnahan/Ferguson group at the San Francisco VA Medical Center and UCSF; the Reinkensmeyer lab at UC Irvine; the Havton lab at UCLA; the California National Primate Research Center located at UC Davis; and the Courtine lab at the Swiss Federal Institute of Technology. Experiments have been collectively designed and performed by this consortium, an unprecedented effort in SCI research to advance the field through close collaboration and interaction on jointly performed experiments. Throughout, this project will benefit from a free exchange of information among the collaborators.

该项目旨在开发神经干细胞（NSC）治疗以修复受伤的脊髓并支持功能恢复。在拟议的工作中，我们旨在将该计划推向成立阶段。此外，我们旨在继续开发和优化潜在的干细胞通过检查创新康复的组合和具有神经元干细胞疗法的脊髓神经调节策略可能会扩大干细胞介导的功能恢复。最后，我们旨在投入大量努力来评估慢性科学的NSC效率。这项工作的重点是源自联邦“批准”人类胚胎的人类NSC 单元格（ESC）线，H9 ESC线。我们本文提出的研究将在临床上主要使用相关的脊髓损伤挫伤模型。在外面的调查员独立复制将举办这个科学家联盟。值得注意的是，这是研究脊柱的领先实验室的内在协作努力绳索损伤，包括圣地亚哥弗吉尼亚州医疗中心和UCSD的Tuszynski组（包括Rosenzweig博士，Lu和Brock）； San的Beattie/Bresnahan/Ferguson Group Francisco VA医疗中心和UCSF； UC Irvine的Reinkensmeyer实验室；哈夫顿实验室 ucla;位于加州大学戴维斯分校的加利福尼亚国家灵长类动物研究中心；和法庭瑞士联邦技术学院的实验室。实验已被集体设计并由该财团进行，这是SCI研究中前所未有的努力来推进该领域通过在共同执行的实验上进行密切合作和互动。在整个过程中项目将受益于合作者之间的免费信息。