Engineered immunotherapies neutralizing interleukin-22 binding protein

中和白细胞介素 22 结合蛋白的工程免疫疗法

基本信息

  • 批准号:
    10538770
  • 负责人:
  • 金额:
    $ 19.74万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-01 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are commonly treated with monoclonal antibodies against inflammatory cytokines. However, a large proportion of patients do not respond to such biologics or experience diminishing efficacy over time. Additionally, episodic dosing can exacerbate the production of anti-drug antibodies. Even in responding patients, while anti-cytokine therapies can ameliorate disease symptoms, they often fail to induce adequate intestinal epithelial regeneration. There is therefore a critical unmet need for an alternative therapy for inflammatory bowel disease that generates predictable therapeutic efficacy for broad patient populations by both reducing inflammation and promoting tissue regeneration. Active Immunotherapy, where anti-inflammatory immune responses are generated within the patient using engineered immunogens, is an alternative but nascent strategy that may offer improved therapeutic efficacy. This project aims to design an active immunotherapy against a key mediator of inflammatory bowel disease, IL-22 binding protein (IL-22BP). The cytokine it inhibits, IL-22, is a member of the IL-10 family and plays a central role in regulating the intestinal barrier in healthy tissue and during epithelial regeneration; thus, neutralizing IL-22BP promises to facilitate the pro- regenerative properties of IL-22 for the amelioration of IBD. Active immunotherapies will be designed using innovative supramolecular nanomaterials designed to contain precise quantities of B-cell epitopes raising neutralizing responses against IL-22BP and TNF, along with exogenous T-cell epitopes designed to provide CD4+ T cell help without breaking T-cell tolerance to the native cytokines. Efficacy will be assessed in a murine model of dextran sodium sulfate-induced colitis. If successful, this high risk/high reward project will establish a-proof-of-concept for combinatorial active immunotherapies that are both anti-inflammatory and regenerative in the context of IBD, constituting a first demonstration of this strategy that could have broader application to other inflammatory diseases and cytokines.
炎症性肠病,包括溃疡性结肠炎和克罗恩病,通常用

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Joel H Collier其他文献

Joel H Collier的其他文献

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{{ truncateString('Joel H Collier', 18)}}的其他基金

Supramolecular biomaterials for tuning the inflammatory properties of the complement system
用于调节补体系统炎症特性的超分子生物材料
  • 批准号:
    10538835
  • 财政年份:
    2022
  • 资助金额:
    $ 19.74万
  • 项目类别:
Supramolecular biomaterials for tuning the inflammatory properties of the complement system
用于调节补体系统炎症特性的超分子生物材料
  • 批准号:
    10631187
  • 财政年份:
    2022
  • 资助金额:
    $ 19.74万
  • 项目类别:
Engineered immunotherapies neutralizing interleukin-22 binding protein
中和白细胞介素 22 结合蛋白的工程免疫疗法
  • 批准号:
    10688059
  • 财政年份:
    2022
  • 资助金额:
    $ 19.74万
  • 项目类别:
Sublingual Supramolecular Vaccines and Immunotherapies
舌下超分子疫苗和免疫疗法
  • 批准号:
    10671694
  • 财政年份:
    2021
  • 资助金额:
    $ 19.74万
  • 项目类别:
Supramolecular peptide immunotherapies for peanut allergy
花生过敏的超分子肽免疫疗法
  • 批准号:
    10416075
  • 财政年份:
    2021
  • 资助金额:
    $ 19.74万
  • 项目类别:
Supramolecular peptide immunotherapies for peanut allergy
花生过敏的超分子肽免疫疗法
  • 批准号:
    10317230
  • 财政年份:
    2021
  • 资助金额:
    $ 19.74万
  • 项目类别:
Sublingual Supramolecular Vaccines and Immunotherapies
舌下超分子疫苗和免疫疗法
  • 批准号:
    10390493
  • 财政年份:
    2021
  • 资助金额:
    $ 19.74万
  • 项目类别:
Engineering Adaptive Immune Responses from Hydrogel Scaffolds to Promote Tissue Regeneration
利用水凝胶支架设计适应性免疫反应以促进组织再生
  • 批准号:
    10571804
  • 财政年份:
    2020
  • 资助金额:
    $ 19.74万
  • 项目类别:
Engineering Adaptive Immune Responses from Hydrogel Scaffolds to Promote Tissue Regeneration
利用水凝胶支架设计适应性免疫反应以促进组织再生
  • 批准号:
    10343752
  • 财政年份:
    2020
  • 资助金额:
    $ 19.74万
  • 项目类别:
Engineering Adaptive Immune Responses from Hydrogel Scaffolds to Promote Tissue Regeneration
利用水凝胶支架设计适应性免疫反应以促进组织再生
  • 批准号:
    10117193
  • 财政年份:
    2020
  • 资助金额:
    $ 19.74万
  • 项目类别:

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血液转录组学作为 CT 佐剂排除急性中风出血
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血液转录组学作为 CT 佐剂排除急性中风出血
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