2022 International Conference on Gram Positive Pathogens

2022年革兰氏阳性病原体国际会议

• 批准号: 10539629
• 负责人: Francis Alonzo
• 金额: $ 0.7万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10539629
• 关键词: Adult; Anabolism; Antibiotic Resistance; Antibiotic-Associated Colitis; Antibiotics; Award; Bacteria; Bacterial Antibiotic Resistance; Biological Process; Biology; Burn injury; COVID-19 pandemic; Cell Communication; Cell Wall; Cells; Cellular biology; Clostridium difficile; Collaborations; Communities; Data; Enterocolitis; Epidemiology; Faculty; Fees; Florida; Fostering; Funding; Gram-Negative Bacteria; Gram-Positive Bacteria; Grant; Great Plains; Health care facility; Hospitals; Individual; Infection; Institution; International; Knowledge; Medical; Medical center; Membrane; Nebraska; Necrotizing fasciitis; Oral; Organism; Participant; Pathogenesis; Principal Investigator; Prokaryotic Cells; Protein Secretion; Proteins; Protocols documentation; Research; Research Personnel; Schools; Science; Scientist; Senior Scientist; Skin Tissue; Soft Tissue Infections; Travel; United States; United States Food and Drug Administration; Universities; career; graduate student; interest; meetings; methicillin resistant Staphylococcus aureus; mortality; novel therapeutics; pathogen; posters; professor; stem; supportive environment; symposium; undergraduate student

Project Summary The International Conference on Gram-Positive Pathogens (ICGPP) brings together scientists at all stages of their careers to exchange ideas and research strategies stemming from shared interests in gram-positive pathogens. This conference, initially held in 2006 and then continued in 2008, 2010, 2012, 2014, 2016, and 2018 because of participant enthusiasm, grew out of collaborations between investigators at the University of Nebraska Medical Center and other academic institutions in the great plains region of the United States. The overarching benefit of ICGPP is the opportunity for investigators to share the science, approaches, and protocols that are unique to gram-positive bacteria in contrast to gram-negative bacteria. While gram-positive pathogens cause myriad infections, ranging from antibiotic-associated colitis to necrotizing fasciitis, fundamental aspects of biological function such as protein secretion across single membranes, cell wall biosynthesis and protein anchoring, and cell-cell communication are shared between this group of medically important bacteria. The impact of gram-positive infections continues to grow, and antibiotic resistance remains a significant threat. As an example, Clostridioides difficile enterocolitis, once primarily associated with antibiotic use in hospitals, is now found in young, healthy adults that do not have an epidemiological relationship to a healthcare facility. Recent data suggests that infections caused by C. difficile are the leading cause of mortality among antibiotic-resistant bacteria in the US. In addition, community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strain USA300 continues to cause skin and soft tissue infections in schools, locker rooms, and hospitals in otherwise healthy individuals. This R13 application is requesting funds to support the 8th ICGPP to be held October 9 -12, 2022 in Omaha, Nebraska. Our diverse organizing and scientific committee comprises ten principal investigators from various academic institutions representing the full range of medically relevant gram- positive bacteria. Although other meetings exist in the US that cover various aspects of bacterial pathogenesis or prokaryotic biology, this is the only meeting focused specifically on gram-positive pathogenesis and biology, and which provides a collegial and supportive environment that fosters interactions between established investigators and junior scientists. Young scientists have the option of presenting their research in either poster or oral format and, in 2018, out of the 27 non-keynote speakers, 17 trainees and 8 Assistant Professors gave oral research presentations. Four internationally known scientists have already agreed to give keynote presentations at the 2022 ICGPP: Drs. Andreas Peschel (University of Tubingen), Drusilla Burns (U.S. Food and Drug Administration), Shonna McBride (Emory University) and Jose Lemos (University of Florida). To keep registration fees low for participants and to encourage the engagement of young investigators, we request funds to support travel of our keynote speakers and for 20 travel grants that will be awarded to trainees.

项目摘要 革兰氏阳性病原体国际会议（ICGPP）汇集了所有阶段的科学家， 他们的职业生涯交流思想和研究战略源于共同的利益，革兰氏阳性 病原体该会议最初于2006年举行，然后在2008年，2010年，2012年，2014年，2016年和2018年继续举行 由于参与者的热情，来自大学研究人员之间的合作， 内布拉斯加州医学中心和美国大平原地区的其他学术机构。的 ICGPP的首要好处是研究人员有机会分享科学、方法和协议 与革兰氏阴性细菌相比，革兰氏阳性细菌所特有的。而革兰氏阳性病原体 引起无数的感染，从过敏性结肠炎到坏死性筋膜炎， 生物学功能，如蛋白质跨膜分泌、细胞壁生物合成和蛋白质 锚定和细胞间通讯在这组医学上重要的细菌之间共享。的 革兰氏阳性菌感染的影响继续扩大，抗生素耐药性仍然是一个重大威胁。作为 例如，艰难梭菌肠炎，曾经主要与医院使用抗生素有关，现在 在年轻健康的成年人中发现，与医疗机构没有流行病学关系。最近 数据表明，由C.艰难梭菌是耐药结核病患者死亡的主要原因 美国的细菌此外，社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA） USA300菌株继续在美国的学校、更衣室和医院引起皮肤和软组织感染， 健康的个体。这份R13申请要求提供资金，以支持将于2013年12月28日举行的第八届ICGPP会议。 2022年10月9日至12日，内布拉斯加州奥马哈。我们多元化的组织和科学委员会由10名 来自不同学术机构的主要研究者代表了医学相关的全方位的克- 阳性细菌尽管在美国也有其他的会议，涵盖了细菌发病机制的各个方面， 或原核生物学，这是唯一一次专门关注革兰氏阳性致病机理和生物学的会议， 它提供了一个合议和支持性的环境，促进建立之间的互动 调查员和初级科学家。年轻的科学家可以选择在任何一张海报上展示他们的研究 或口头形式，并在2018年，在27个非主题演讲者，17名学员和8名助理教授给 口头研究报告。四位国际知名科学家已经同意发表主题演讲 在2022 ICGPP上的演讲：Andreas Peschel博士（图宾根大学），Drusilla Burns（美国食品和药物管理局） 药物管理局），肖娜麦克布赖德（埃默里大学）和何塞莱莫斯（佛罗里达大学）。保持 为了降低参与者的注册费，并鼓励年轻调查人员的参与，我们要求提供资金， 支持我们的主旨发言人的旅行，并为20名学员提供旅行补助。