Promotion of NAD+ anabolism to promote lifespan

点击翻译按钮获取中文摘要

The project aims to identify mechanisms of ageing, the role of stress on the ageing brain and how NAD+ modulates these effects. NAD+ maintains cellular energy, repairs DNA and performs other essential cell functions. Intracellular NAD+ levels, the essential substrate for sirtuin activity including SIRT2, decline with age in humans and physiologically aged rats. This project will investigate the mechanisms by which pharmacological strategies designed to elevate intracellular NAD+ levels will maintain optimal SIRT2 function to extend lifespan and improve age-related cognitive decline in vivo. Potential outcomes include using NAD+ to improve brain health in advanced old age.