Neuropsychological Profiles and Risk for Dementia-Related Disease in Mothers of Children with Autism Spectrum Disorder

自闭症谱系障碍儿童母亲的神经心理学特征和痴呆相关疾病的风险

• 批准号: 10537925
• 负责人: LAURA ANNE FRIEDMAN
• 金额: $ 6.99万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2025-08-21
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10537925
• 关键词: Address; Adolescent; Adult; Adult Children; Affect; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Caregivers; Caring; Child; Child Rearing; Cognition; Cognitive; Cognitive aging; Cognitive deficits; Coupled; Data; Dementia; Development; Disabled Children; Disease; Disease susceptibility; Elderly; Environment; Environmental Risk Factor; Evaluation of Risk Factors; Face; Family; Fibrinogen; Fragile X Syndrome; General Population; Genes; Genetic; Grant; Heritability; High Prevalence; Home; Impaired cognition; Infrastructure; Language; Literature; Loneliness; Measurement; Measures; Memory; Mental Depression; Mentors; Mentorship; Modeling; Mothers; Neurodevelopmental Disorder; Neuropsychological Tests; Neuropsychology; Outcome; Parents; Participant; Pattern; Performance; Phenotype; Population; Predisposition; Psychosocial Factor; Public Health; Questionnaires; Reporting; Research; Resources; Risk; Risk Factors; Role; Short-Term Memory; Social support; Source; South Carolina; Stress; Supervision; Tauopathies; Training; Universities; Work; age effect; age group; age related; autism spectrum disorder; autistic children; base; cognitive performance; comparison group; dementia risk; disorder risk; experience; high school; human old age (65+); insight; middle age; mild cognitive impairment; performance tests; poor sleep; psychosocial; public health relevance; sleep quality; social; tau Proteins; theories; training project

PROJECT SUMMARY Recent work suggests that mothers of children with disabilities are at increased risk for accelerated cognitive aging. Mothers of children with autism spectrum disorder (ASD), in particular, may be especially susceptible to atypical aging given their elevated rates of key risk factors for dementia relative to mothers of typically developing children or children with other neurodevelopmental disorders. ASD is also a heritable condition, and emerging research indicates similar effects of tauopathy in ASD and Alzheimer’s disease. Though it is not known if mothers of children with ASD also have tauopathy as a result of their genetic liability, this possibility may have an impact on atypical cognitive aging in this group. The theoretical framework from this research is based on the Diathesis-Stress model, which posits that environmental or psychosocial factors (e.g., stress) moderate the gene-phenotype relationship. Understanding risk for atypical cognitive decline in mothers of children with ASD is important given the high prevalence of ASD in the population (1 in 54 children). Moreover, a significant number of mothers of children with ASD (up to 65%) continue to be caregivers for their adult children, resulting in increased stress, depression, loneliness, reduced social support, and poor sleep, all of which are risk factors for dementia-related disease. This project will address gaps in the literature on cognitive decline in mothers of children with ASD and associated risk factors. Aim 1 will compare the neuropsychological profiles of mothers of children with ASD and mothers of typically developing children, as well as age effects, using a comprehensive battery. Aim 2 will examine the effects of risk factors (i.e., stress, depression, loneliness, reduced social support, and poor sleep quality) on neuropsychological test performance within mothers of children with ASD. This project will provide insight into atypical cognitive aging among mothers of children with ASD, which may have broader consequences on their children who continue to live at home and depend on their parents as caregivers after high school. This research will be implemented in an ideal training environment with a strong infrastructure for aging research at the University of South Carolina and with the support of an experienced mentorship team with expertise in aging, neuropsychological assessments, and Alzheimer’s and other dementia-related diseases. The training plan focuses on the development of the trainee in: (1) theories, measurement, and interpretation of neuropsychological assessments, (2) trajectories of typical aging and aging in dementia-related disease, and (3) professional development. The proposed study and training plan will help the trainee pursue a line of research on the risk for dementia-related disease in mothers of children with ASD.

项目总结 最近的研究表明，残疾儿童的母亲认知加速的风险更大。 衰老。患有自闭症谱系障碍(Asd)儿童的母亲可能特别容易患上 非典型老龄化，因为与典型的母亲相比，他们患痴呆症的关键危险因素的比率更高 发育中的儿童或患有其他神经发育障碍的儿童。ASD也是一种可遗传的疾病， 新出现的研究表明，自闭症和阿尔茨海默病的紧张症效果相似。虽然它不是 已知患有自闭症儿童的母亲是否也因其遗传易感性而患有直肠紧张症，这种可能性 可能会对这一群体中的非典型认知老化产生影响。这项研究的理论框架是 基于素质-压力模型，该模型假设环境或心理社会因素(例如，压力) 调节基因-表型关系。了解儿童母亲非典型认知功能减退的风险 鉴于自闭症在人口中的高患病率(每54名儿童中有1名)，患有自闭症的儿童很重要。此外， 相当数量的自闭症儿童的母亲(高达65%)继续照顾他们的成年人 儿童，导致压力增加，抑郁，孤独，社会支持减少，睡眠不佳，所有这些 这些都是痴呆症相关疾病的危险因素。这个项目将解决关于认知的文献中的空白。 患有自闭症儿童的母亲数量下降及相关危险因素。目标1将比较神经心理学 患有自闭症儿童的母亲和典型发育儿童的母亲的概况，以及年龄影响， 使用综合电池。目标2将检查风险因素(即压力、抑郁、 孤独感、社会支持减少和睡眠质量差)对 患有自闭症儿童的母亲。该项目将深入了解儿童母亲的非典型认知老化情况。 患有自闭症的儿童，这可能会对继续生活在家里和 高中毕业后依靠父母照看孩子。这项研究将在理想的培训中实施 南卡罗来纳大学具有强大的老龄化研究基础设施的环境，以及 支持一支经验丰富的导师团队，他们在老龄化、神经心理评估和 阿尔茨海默氏症和其他与痴呆相关的疾病。培训计划的重点是学员的发展 在：(1)神经心理评估的理论、测量和解释；(2)典型的 衰老和痴呆相关疾病中的衰老，以及(3)职业发展。拟议的研究和 培训计划将帮助学员进行一系列关于母亲患痴呆症相关疾病风险的研究 患有自闭症的儿童。