Endemic and Emerging Multidrug Resistant Organisms in Nursing Homes: A Neglected Clinical Setting
疗养院中流行和新兴的多重耐药微生物:一个被忽视的临床环境
基本信息
- 批准号:10537752
- 负责人:
- 金额:$ 4.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-27 至 2025-06-26
- 项目状态:未结题
- 来源:
- 关键词:AcuteAddressAdverse eventAffectAmericanAntibiotic ResistanceAntibioticsBathingBiometryCOVID-19 pandemicCaliforniaCandida aurisCaringCase MixesCharacteristicsClinicalClinical ResearchCommunicable DiseasesCountyDataDevicesDisease OutbreaksDoctor of PhilosophyEnvironmentEnvironmental PollutionEpidemiologyFellowshipGoalsHeadHealth care facilityHealthcareHome Nursing CareHospitalsIncontinenceIndividualInfectionInfection preventionInfectious Disease EpidemiologyIntensive Care UnitsInterventionInvestigationLinkLong-Term CareMeasuresMentorsMorbidity - disease rateNursing HomesOrangesPatientsPerformancePrevalencePrevalence StudyPreventionProspective StudiesPublic HealthPublic Health NursingQuality of CareResearchResearch TrainingResourcesRiskRisk FactorsSamplingSiteSterile coveringsSurfaceSystems BiologyTouch sensationTrainingUniversitiesVirulentWorkadverse outcomeattributable mortalitycareercomorbiditydrug resistant pathogenepidemiology studyfungushigh riskimprovedinfection riskmethicillin resistant Staphylococcus aureusmortalitymulti-drug resistant pathogenmultidisciplinaryneglectnoveloperationpathogenpathogenic funguspatient populationpopulation healthpreventresponsescreeningskillstransmission processwound
项目摘要
Project Summary/Abstract
Individuals receiving care in nursing homes disproportionally experience adverse outcomes due to
multidrug-resistant organisms. This investigation will focus on an endemic and virulent pathogen common to
nursing homes – methicillin-resistant Staphylococcus aureus (MRSA), and a highly emerging antibiotic
resistant fungus – Candida auris, both of which have been linked to substantial morbidity and mortality in U.S.
nursing homes. While MRSA has been a major prevention target in hospitals, little has been done to address
this pathogen in nursing homes despite the fact that nursing homes have a 3-fold higher MRSA prevalence
than hospitals and MRSA carriers in nursing homes have a 40% risk of infection per year.
Risk in nursing homes due to MRSA is now compounded by C. auris, which has been termed the
“fungal MRSA” due to similar transmission characteristics, including a remarkable propensity to colonize the
body and persist on surfaces for prolonged periods. C. auris has been associated with intractable outbreaks in
nursing homes with high attributable mortality; 5-10% of known carriers develop invasive infections and 30-
60% of those with invasive infection die as a result. Thus, determining which nursing home residents are at
greatest risk for MRSA and C. auris carriage is crucial for effective response and control.
The overall goal of this proposal is to generate novel data on MRSA and C. auris carriage and
contamination in nursing homes to inform interventions to control these important pathogens. The first
objective is to identify nursing home facility characteristics and resident risk factors associated with MRSA and
C. auris carriage. Results from this objective could target high-risk residents for screening and prevention
activities. The second objective is to determine if high-contact care activities (e.g., dressing, bathing) for MRSA
and C. auris carriers cause contamination of high-touch objects in their immediate environment. If so, focused
post-activity cleaning could be important to reduce MRSA and C. auris contamination and mitigate spread.
I (Gabrielle Gussin, MS) am pursuing a Ph.D. in Public Health at the University of California, Irvine. This
F31 fellowship will enable me to bridge my previous Master’s training in Systems Biology with skills in
epidemiology, clinical research, and population health. I will be mentored by a multidisciplinary team with
expertise in clinical infectious diseases, epidemiology, multidrug-resistant organisms, public health, nursing
home operations, and biostatistics to support my proposed aims and career goals.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Gabrielle Gussin其他文献
Gabrielle Gussin的其他文献
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{{ truncateString('Gabrielle Gussin', 18)}}的其他基金
Endemic and Emerging Multidrug Resistant Organisms in Nursing Homes: A Neglected Clinical Setting
疗养院中流行和新兴的多重耐药微生物:一个被忽视的临床环境
- 批准号:
10671477 - 财政年份:2022
- 资助金额:
$ 4.19万 - 项目类别:
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