Botswana CASCADE Clinical Trials Site

博茨瓦纳 CASCADE 临床试验现场

• 批准号: 10544424
• 负责人: Scott Dryden-Peterson
• 金额: $ 25.78万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-05 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10544424
• 关键词: AIDS clinical trial group; AIDS related cancer; Ablation; Acquired Immunodeficiency Syndrome; Africa; African; Area; Botswana; COVID-19 Prevention Network; Caring; Cause of Death; Cervical; Cervical dysplasia; Cessation of life; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical Trials Unit; Collaborations; Communities; Community Health Education; Consumption; Country; Cryptococcosis; Data; Devices; Dysplasia; Early Diagnosis; Early treatment; Economic Factors; Effectiveness; Enrollment; Ethics; Ethnic Origin; Evaluation; Female Adolescents; Geography; HIV; HIV diagnosis; Health Services Accessibility; Health system; High Prevalence; Human Papilloma Virus Vaccination; Human Papillomavirus; Immunotherapy; Impairment; Improve Access; Income; Institutes; International; International Agencies; International Maternal Pediatric Adolescent AIDS Clinical Trials; Laboratories; Language; Lesion; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentors; Observational Study; Oncology; Outcome; Participant; Patient Recruitments; Patient risk; Patients; Performance; Persons; Population; Prevalence; Prevention; Preventive service; Protocols documentation; Quality Control; Relapse; Research; Research Personnel; Resources; Sampling; Site; Southern Africa; Target Populations; Techniques; Technology; Time; Training; Treatment Effectiveness; Tuberculosis; United States National Institutes of Health; Universal Coverage; Vaccines; Viral; Woman; aged; antenatal care; antiretroviral therapy; breast cancer diagnosis; cancer diagnosis; cancer invasiveness; cancer prevention; cancer therapy; clinical research site; cohort; community engagement; comparative trial; data management; data quality; effectiveness evaluation; experience; improved; innovation; mortality; new technology; novel; pragmatic trial; premalignant; prevent; programs; prospective; quality assurance; randomized trial; research study; screening; screening program; treatment optimization; treatment program; uptake

Project Summary / Abstract Successful HIV treatment programs in Botswana and elsewhere in southern Africa have led to dramatic reductions in mortality from tuberculosis, cryptococcosis, and other non-cancer AIDS deaths. However, cancer deaths have not decreased, and cervical cancer now is the leading cause of death for women living with HIV in the region. Cervical cancer is preventable with early detection and treatment of precancerous lesions but challenges of limited access to initial screening, poor performance of initial screening technologies, high prevalence of cervical precancers, and persistent or relapsed dysplasia following therapy impair the impact of programs for women living with HIV. Working to develop strategies to these challenges, we will establish the Botswana CASCADE Clinical Trials Site at BHP that will participate in and contribute to the following high- impact areas of research: 1) Enhancing cervical precancer screening uptake through patient and context relevant approaches, including HPV self-sampling, non-clinical screening venues, and screening during antenatal care; 2) Strategies and novel technologies to improve management of positive HPV initial screening maximize prevention of invasive cancer while minimizing patient risk and consumption of health system resources; 3) Improving precancer treatment access, treatment completion, and outcomes; and 4) Optimizing treatment approaches to cervical precancers including comparative trials of ablation techniques, intervals of repeat evaluation, and vaccines or other immunologic therapies. The Botswana CASCADE Clinical Trials Site will contribute to conducting high-quality clinical research studies, provide context-relevant input on developing trial concepts, understand disparity in access by geography, economic factors, and language/ethnicity, and continue to develop local research capacity through mentoring and training.

项目摘要/摘要 博茨瓦纳和南部非洲其他地区成功的艾滋病毒治疗计划带来了戏剧性的 结核病、隐球菌病和其他非癌症艾滋病死亡的死亡率降低。然而，癌症 死亡人数没有减少，宫颈癌现在是#年艾滋病毒携带者妇女的主要死因。 该地区。宫颈癌是可以通过早期发现和治疗癌前病变来预防的，但是 获得初始筛查的机会有限、初始筛查技术表现不佳、 宫颈癌前病变的流行，以及治疗后持续或复发的异型增生损害了 为艾滋病毒携带者妇女提供的方案。努力制定应对这些挑战的战略，我们将建立 必和必拓的博茨瓦纳级联临床试验网站将参与并促进以下高- 研究影响领域：1)通过患者和背景加强对宫颈癌前筛查的了解 相关方法，包括HPV自我采样、非临床筛查场所和期间筛查 产前护理；2)改善HPV阳性初步筛查管理的战略和新技术 最大限度地预防浸润性癌症，同时最大限度地减少患者风险和医疗系统的消耗 资源；3)改善癌症前治疗的可获得性、治疗完成率和结果；4)优化 宫颈癌前病变的治疗方法，包括消融技术的比较试验，间隔 重复评估，并接种疫苗或其他免疫疗法。博茨瓦纳CASCADE临床试验网站 将有助于进行高质量的临床研究，提供与背景相关的意见 开发试验概念，了解地理、经济因素和 语言/族裔，并继续通过指导和培训发展当地的研究能力。