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An effectiveness trial of WINGS+PrEP: a syndemic mHealth intervention to increase PrEP uptake among women impacted by heavy alcohol use and partner violence in the criminal legal system

An effectiveness trial of WINGS+PrEP: a syndemic mHealth intervention to increase PrEP uptake among women impacted by heavy alcohol use and partner violence in the criminal legal system
WINGS PrEP 的有效性试验:一种同步流行病移动健康干预措施,旨在提高刑事法律系统中受酗酒和伴侣暴力影响的妇女对 PrEP 的采用
批准号:
10541692
负责人:
Anindita Dasgupta
金额:
$76.58万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-09-01 至 2027-06-30
关键词:
AIDS preventionAddressAdherenceAdoptionAgeAlcoholsAreaBiological AssayBlack raceCommunitiesDecision MakingDrug LegislationEducationEffectivenessEligibility DeterminationEnrollmentEthnic OriginFemaleFortuneGeneral PopulationGoalsHIVHIV InfectionsHIV riskHeavy DrinkingHousingHybridsImprisonmentIndividualInterventionIntervention StudiesLatinxLegal systemMeasuresMedicalMedical RecordsMultiple PartnersNew York CityNot Hispanic or LatinoOutcomeOutcome StudyParticipantPatient Self-ReportPopulationPractical Robust Implementation and Sustainability ModelPrevention strategyProcessRaceRandomizedRandomized Controlled TrialsReach Effectiveness Adoption Implementation and MaintenanceRecording of previous eventsReduce health disparitiesReportingResearch PersonnelRisk BehaviorsSafetySeveritiesSex OrientationSocietiesSubgroupSubstance Use DisorderSupervisionTelemedicineTenofovirTestingTimeUnsafe SexUrineViolenceWingWomanalcohol screening and brief interventionbaseblack womencis-femalecomparative cost effectivenesscomparative effectivenesscontextual factorscostcost effectivenesscost efficientdesigndigitaleffectiveness implementation trialeffectiveness testingeffectiveness trialeffectiveness-implementation RCTevidence basefollow-uphazardous drinkinghealth equityhealth inequalitieshigh riskhigh risk populationhybrid type 1 trialimplementation frameworkimplementation researchinnovationintimate partner violencelensliteracymHealthnovelparolepartner violencepeerpost interventionpre-exposure prophylaxispreventprimary outcomeprobationprogramsracial health disparityrecidivismscale upscreening, brief intervention, referral, and treatmentsecondary outcomesexsocial stigmasyndemictooluptakeviolence exposure

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PROJECT SUMMARY The proposed hybrid type 1 Effectiveness and Implementation randomized controlled trial (RCT) will evaluate an m-Health syndemic intervention (WINGS+PrEP) that aims to increase HIV pre-exposure prophylaxis (PrEP) initiation and adherence among women in community supervision programs (CSPs) including probation, parole and alternative-to-incarceration (ATI) programs) in New York City (NYC) who report hazardous drinking. To date, very few PrEP interventions, have focused on cis-gender women, and none have targeted the large population of women in CSPs, who due to racialized drug laws, are disproportionately Black and Latinx. Advancing an effective PrEP intervention for women in CSPs holds promise for reducing HIV disparities by reaching a disproportionately large number of Black and Latinx women who remain at high risk for HIV. PrEP presents a unique opportunity for women to engage in a female-controlled HIV prevention strategy, which is vitally important within the context of hazardous drinking and violent partners. To date, however, there are no evidence-based syndemic-focused PrEP interventions for women that address hazardous drinking and IPV exposure. The proposed study intervention (WING+PrEP) is a 3-session syndemic focused intervention that combines an evidence-based mHealth Alcohol Screening, Brief Intervention and Referral to Treatment (SBIRT) tool, and an evidence-based mHealth IPV SBIRT tool - WINGS with an evidence-based PrEP intervention that includes a PrEP decision making aid with novel peer navigation and telemedicine components. The proposed RCT will be conducted with 300 women in CSPs Eligible women will be randomly assigned to: (1) WINGS+PrEP or (2) PrEP Alone that consists of the same evidence-based PrEP decision making aid single session with peer navigation. Both conditions will be delivered by Fortune Society a large community based organization that serves women in CSPs. Repeated assessments will occur at baseline and 3, 6, and 12-months post intervention. This study will be guided by the PRISM/RE-AIM(S) implementation science framework with a health equity lens and will examine how multilevel contextual factors may influence the reach, effectiveness, adoption, implementation, maintenance and sustainability (RE-AIMS) of WINGS+PrEP and PrEP and how these contextual factors and processes may interact to promote or impede health equity. If WINGS+PrEP is found to be effective, it's low threshold format is designed to be scaled up in CSP settings nationwide to curb HIV infection and to reduce HIV disparities among women from heavily impacted communities.
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