Reducing the intersecting stigmas of HIV, violence victimization, and mental health: a randomized controlled pilot integrating Project YES! Youth Engaging for Success and Problem Management Plus amon

减少艾滋病毒、暴力受害和心理健康的交叉耻辱：整合“YES！”项目的随机对照试点

• 批准号: 10542948
• 负责人: Julie Anne Denison
• 金额: $ 22.89万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10542948
• 关键词: 19 year old; AIDS prevention; AIDS/HIV problem; Address; Adherence; Adolescence; Adolescent; Adolescent Health Services; Adolescent and Young Adult; Adult; Africa South of the Sahara; Age; Anti-Retroviral Agents; Anxiety; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Childhood; Chronic Disease; Clinic; Cognitive; Complex; Data; Data Collection; Development; Emotions; Ensure; Evidence based intervention; Failure; Feeling; Frequencies; Future; Goals; Guilt; HIV; Health; Interruption; Intervention; Link; Literature; Measurement; Measures; Mental Depression; Mental Health; Mentors; Odds Ratio; Outcome; PF4 Gene; Participant; Pathway interactions; Pediatric Hospitals; Population; Process; Randomized; Randomized Controlled Trials; Research; Risk; Services; Shame; Social Identification; South African; System; Testing; Thailand; United States National Institutes of Health; Victimization; Violence; Viral; Viral Load result; World Health Organization; Youth; Zambia; acceptability and feasibility; age group; antiretroviral therapy; base; cognitive interview; depressive symptoms; design; emotional abuse; experience; feasibility testing; health training; improved; internalized stigma; low and middle-income countries; medication compliance; peer; peer coaching; programs; psychologic; psychological violence; reduce symptoms; response; sexual violence; skills; social; social stigma; standard of care; success; systematic review; therapy adherence; violence victimization

PROJECT SUMMARY / ABSTRACT Stigma is increasingly recognized as a modifiable factor impacting antiretroviral therapy adherence and viral suppression among adolescents and young adults living with HIV (AYALHIV), however few interventions have effectively reduced stigma or address intersectional stigma among this population. In this study we will address internalized HIV stigma among AYALHIV, as well as internalized stigmas related to the prevalent youth experiences of violence and depression. Further, we will also focus on intersectional stigma, capturing anticipated stigma associated with the complex reality of AYALHIV’s multiple social identities. We will create an intervention to reduce these multiple stigmas by building upon the evidence-based intervention Project YES! Youth Engaging for Success. Project YES! is a peer mentoring program that effectively reduced HIV-internalized stigma among 15-to 24-year old AYALHIV in Zambia, and among a subset of pediatric clinic participants, increased their viral suppression. Project YES! data also highlighted critical intervention gaps, including high levels of physical, sexual and/or emotional violence victimization among AYALHIV, and how participants who screened positive for depression had lower levels of viral suppression. This data aligns with a growing body of evidence linking violence victimization and depression with internalized stigma and viral failure. Project YES! peer mentors would refer participants with violence experiences or depression and anxiety to the clinic health staff in a system that provides minimal mental health training or services for AYALHIV. This research seeks to address this gap by integrating the stigma reducing EBI youth peer mentoring program (Project YES!) with the World Health Organization endorsed and proven mental health approaches that reduce symptoms of depression and anxiety (Problem Management Plus (PM+) and Early Adolescent Skills for Emotions (EASE)) that are delivered by lay health workers. By adapting and integrating PM+/EASE to create Project YES+, we will specifically provide AYALHIV with problem-management skills that we hypothesize will interrupt the bi-directional pathways among violence victimization, depression and internalized and intersectional stigmas. We will also refine our measures of internalized stigmas related to violence and depression, and intersectional stigma. Specific study aims include: AIM 1: Adapt and integrate the WHO problem management-based PM+/EASE approaches for AYA (15-24 years) to create Project YES+ for implementation by lay youth mentors to improve viral status by reducing the internalized and intersectional stigmas related to HIV, violence, and depression. Aim 2: Use cognitive interviewing to adapt scales of violence- and depression-related internalized stigma and intersectional stigma to improve stigma measurement among AYAHLIHV. Aim 3: Assess the feasibility and acceptability of a Project YES+ intersectional stigma reduction intervention among 100 AYALHIV through a pilot randomized controlled trial.

项目总结/摘要 污名越来越被认为是影响抗逆转录病毒治疗依从性和病毒感染的一个可改变因素。 艾滋病毒/艾滋病感染者的艾滋病毒/艾滋病控制（AYALHIV），但很少有干预措施 有效地减少了这一群体的耻辱感或解决了这一群体中相互交织的耻辱感。在这项研究中，我们将解决 AYALHIV中内化的艾滋病毒污名，以及与流行的青年有关的内化污名 暴力和抑郁的经历。此外，我们还将关注交叉污名， AYALHIV的多重社会身份的复杂现实与预期的耻辱。我们将创建一个 通过建立基于证据的干预项目YES！ 年轻人追求成功。项目YES！是一个同伴指导计划，有效地减少了艾滋病毒的内化， 赞比亚15至24岁的AYALHIV患者以及一部分儿科诊所参与者中的耻辱感， 增强了他们的病毒抑制能力项目YES！数据还突出显示了关键的干预差距， AYALHIV中的身体、性和/或情感暴力受害程度，以及 抑郁症筛查阳性者的病毒抑制水平较低。这些数据与越来越多的 有证据表明，暴力受害和抑郁症与内化的耻辱和病毒失败有关。项目YES！ 同伴导师会将有暴力经历或抑郁和焦虑的参与者转介到诊所健康 为AYALHIV提供最低限度心理健康培训或服务的系统中的工作人员。这项研究旨在 通过整合减少耻辱感的EBI青年同伴指导计划（YES项目！）与 世界卫生组织认可并证明了减少抑郁症症状的心理健康方法 和焦虑（问题管理+（PM+）和早期青少年情绪技能（EASE））， 由非专业卫生工作者提供。通过调整和整合PM+/EASE来创建Project YES+，我们将 特别是为AYALHIV提供问题管理技能，我们假设这将中断双向的 暴力受害、抑郁以及内化和交叉污名之间的途径。我们还将 完善我们对与暴力和抑郁有关的内化污名以及交叉污名的衡量标准。 具体研究目标包括： 目标1：调整和整合WHO基于问题管理的PM+/EASE方法，用于AYA（15-24 创建YES+项目，由非专业青年导师实施，通过减少 与艾滋病毒、暴力和抑郁症有关的内在和交叉污名。 目标2：使用认知访谈来调整与暴力和抑郁相关的内化污名的量表， 交叉柱头，以改善AYAHLIHV的柱头测量。 目标3：评估YES+项目跨部门减少污名干预的可行性和可接受性 在100 AYALHIV通过试点随机对照试验。