2022 Conference: Clinical and Scientific Advances in Urinary Tract Infections

摘要 尿路感染是困扰1.5亿患者的重大社会经济负担 其中大多数是健康的成年女性。抗生素使用率很高， 治疗急性和反复发作的尿路感染导致尿路感染急剧增加 由抗生素耐药细菌引起的感染数量，包括超广谱β- 产生内酰胺的菌株。有效的抗生素疗法的可获得性的下降已经上升。 需要加快UTI研究的所有方面，如我们的规划主题领域所概述的那样。 这次会议超越了基础科学成果的交流，为临床研究而努力 研究结果的相关性，因为它们可以应用于临床实践以及临床使用 促进新的合作和实验方法的挑战。尽管健康的女性 代表了大多数接受尿路感染治疗的患者，我们将在以前的 调查性别和年龄差异、易感因素和阴性后遗症等方面。 此外，这次会议还为临床医生提供了跨专业(如儿科、老年科、 产科、综合护理、急诊内科、泌尿科和肾脏科) 集思广益的治疗方法，并交流他们的研究需求 直接发送给研究人员，为未来的科学研究提供信息。通过从整体上关注 尿路感染疾病，而不是任何一项研究或临床方法、讨论和合作 可以从长凳上走到床边。作为长期预防和管理计划的一部分 UTI，我们也有一个培训任务来招募和支持早期职业研究人员和那些没有 传统上在医学和研究中的代表，因为他们过渡到下一代 专家。

ABSTRACT Urinary tract infections are a significant socioeconomic burden afflicting 150 million patients worldwide each year, most of whom are healthy adult women. The high rate of antibiotic usage to treat acute and recurrent episodes of urinary tract infection has led to a dramatic increase in the number of infections caused by antibiotic resistant bacteria including extended spectrum beta- lactam producing strains. The decrease in availability of efficacious antibiotic therapies has elevated the need to accelerate all aspects of UTI research as outlined in our programmatic topic areas. This conference goes beyond the exchange of basic science findings and strive for a clinical relevance of research findings as they can be applied to clinical practice as well as using clinical challenges to foster new collaborations and experimental approaches. Although healthy women represent the majority of patients treated for urinary tract infection, we will target previously under investigated areas such as sex and age differences, susceptibility factors and negative sequelae. Further, this conference provides clinicians across specialties (such as pediatrics, geriatrics, obstetrics, complex care, emergency medicine, urology, and nephrology) the opportunity to brainstorm treatment approaches with each other and to communicate their needs for research directly to researchers, informing future lines of scientific inquiry. By focusing holistically on the disease of UTI rather than on any one research or clinical approach, discussions and collaborations can cross from the bench to the bedside. As part of a long-term plan for preventing and managing UTI, we also have a training mission to recruit and support early career researchers and those not traditionally represented in medicine and research as they transition into the next generations of experts.