2022 Conference: Clinical and Scientific Advances in Urinary Tract Infections

2022 年会议：尿路感染的临床和科学进展

• 批准号: 10540602
• 负责人: Christina B Ching
• 金额: $ 0.25万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10540602
• 关键词: Acute; Adult; Antibiotic Resistance; Antibiotic Therapy; Antibiotics; Area; Bacterial Antibiotic Resistance; Basic Science; Buffaloes; Caring; Characteristics; Child; Childhood; Clinical; Clinical Management; Clinical Pathology; Clinical Research; Collaborations; Communicable Diseases; Complex; Diagnosis; Discipline; Discipline of Nursing; Discipline of obstetrics; Disease; Doctor of Philosophy; Elderly; Emergency Medicine; Emergency department visit; End stage renal failure; Ensure; Faculty; Fostering; Future; Geriatrics; Government Agencies; Health; Hospitalization; Human; Hypersensitivity; Hypertension; Immunology; Industrialization; Infection; Institutes; International; Investments; Justice; Lead; Low Birth Weight Infant; Medical; Medicine; Microbiology; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; New York; Ohio; Outcome; Outpatients; Pathogenesis; Patients; Pediatrics; Physician Executives; Practice Management; Predisposition; Pregnancy; Premature Birth; Prevention; Principal Investigator; Queensland; Recovery; Recurrence; Research; Research Personnel; Science; Scientific Advances and Accomplishments; Scientific Inquiry; Scientist; Secure; Sepsis; Series; Sex Differences; Therapeutic; Training; Underrepresented Populations; United States; Universities; Urinary tract; Urinary tract infection; Urologic Diseases; Urology; Visit; Washington; Woman; adverse pregnancy outcome; age difference; alternative treatment; base; bench to bedside; beta-Lactams; biomedical scientist; career; catheter associated UTI; clinical conference; clinical practice; clinically relevant; comorbidity; disability; insight; interest; medical schools; medical specialties; meetings; mental state; mid-career faculty; mortality; multidisciplinary; next generation; novel diagnostics; novel therapeutic intervention; patient population; prevent; professor; recruit; renal scarring; side effect; socioeconomics; symposium; trait; translational approach; translational health science

ABSTRACT Urinary tract infections are a significant socioeconomic burden afflicting 150 million patients worldwide each year, most of whom are healthy adult women. The high rate of antibiotic usage to treat acute and recurrent episodes of urinary tract infection has led to a dramatic increase in the number of infections caused by antibiotic resistant bacteria including extended spectrum beta- lactam producing strains. The decrease in availability of efficacious antibiotic therapies has elevated the need to accelerate all aspects of UTI research as outlined in our programmatic topic areas. This conference goes beyond the exchange of basic science findings and strive for a clinical relevance of research findings as they can be applied to clinical practice as well as using clinical challenges to foster new collaborations and experimental approaches. Although healthy women represent the majority of patients treated for urinary tract infection, we will target previously under investigated areas such as sex and age differences, susceptibility factors and negative sequelae. Further, this conference provides clinicians across specialties (such as pediatrics, geriatrics, obstetrics, complex care, emergency medicine, urology, and nephrology) the opportunity to brainstorm treatment approaches with each other and to communicate their needs for research directly to researchers, informing future lines of scientific inquiry. By focusing holistically on the disease of UTI rather than on any one research or clinical approach, discussions and collaborations can cross from the bench to the bedside. As part of a long-term plan for preventing and managing UTI, we also have a training mission to recruit and support early career researchers and those not traditionally represented in medicine and research as they transition into the next generations of experts.

抽象的 尿路感染是困扰 1.5 亿患者的重大社会经济负担 每年在世界范围内，其中大多数是健康的成年女性。抗生素使用率高 治疗急性和复发性尿路感染导致尿路感染的急剧增加 由抗生素耐药细菌引起的感染数量，包括广谱β- 内酰胺生产菌株。有效抗生素疗法的可用性下降加剧 正如我们的规划主题领域所述，需要加速尿路感染研究的各个方面。 这次会议超越了基础科学成果的交流，力求临床 研究结果的相关性，因为它们可以应用于临床实践以及使用临床 促进新的合作和实验方法的挑战。虽然健康的女性 代表大多数接受尿路感染治疗的患者，我们将之前的目标定位为 调查了性别和年龄差异、易感因素和不良后遗症等领域。 此外，本次会议还为跨专业（例如儿科、老年病学、 产科、综合护理、急诊医学、泌尿科和肾脏科）有机会 互相集思广益治疗方法并交流他们的研究需求 直接向研究人员提供信息，为未来的科学探究提供信息。通过全面关注 尿路感染疾病，而不是任何一项研究或临床方法、讨论和合作 可以从长凳跨越到床边。作为预防和管理长期计划的一部分 UTI，我们还有一个培训任务来招募和支持早期职业研究人员和那些非 传统上代表医学和研究，因为他们过渡到下一代 专家。