mHealth Center for Discovery, Optimization, and Translation of Temporally-Precise Interventions (mDOT)

主要研究者：Kumar，Santosh mHealth发现中心，优化&翻译 时间精确干预（mDOT）-总体 翻译后摘要：为慢性病患者提供护理是国家崛起的最大驱动力之一 医疗保健支出。其中许多疾病与易变的健康行为有着千丝万缕的联系， 饮食、缺乏体育活动和吸烟。制定自我保健和预防性健康行为的关键策略 更容易实现的是通过移动的传感器将被动监测集成到日常生活中， 为患者提供个性化的信息和指导。但是，为了获得最大的长期疗效， 移动卫生干预措施必须在最合适的时机提供，其内容必须动态 个性化的个人，他们的当前环境，和不断变化的偏好。 我们提议的移动健康中心，用于发现，优化和翻译时间精确的干预措施 (the mDOT中心）将为研究人员提供方法，工具和基础设施，以发现，优化和 部署时间精确的移动医疗干预措施。围绕三大技术研发 (TR和D）项目，mDOT代表了一个独特的国家资源，将开发多种方法， 技术创新，包括易于部署的可穿戴设备、可穿戴设备和智能手机应用程序，以及 配套的mHealth云系统，全部开源。TR&D1将开发、评估和传播各种方法， 分析移动健康生物标志物的人口规模多模式时间序列，以确定瞬时风险因素 以及导致不利健康结果的风险动态，同时考虑到不确定性和缺失， 这些数据源中的一部分。TR&D2将开发新的强化学习方法， 在个人的最佳时间和地点选择和提供移动健康干预措施， 保持用户参与度，并提供精确和最大的健康益处。TR&D3将开发、验证和 传播算法、工具和软件/硬件设计，以便大规模部署 资源高效、实时、低延迟和隐私感知的数字生物标志物。这些mDOT 交付成果将改变研究人员和创新者利用传感器爆炸范围的能力， 移动的技术，用于开发和提供动态个性化和时间精确的mHealth 对个人的干预。与合作项目（CP）和直接合作项目的迭代“推拉”交互 向服务项目（SP）的传播将确保我们的TR& D开发的技术解决真实的- 世界问题，可供其他研究人员使用，并将产生最广泛的影响。 mDOT中心的培训和传播（T&D）活动将寻求最大限度地发挥我们的社会影响力。 通过促进广泛传播和采用mDOT技术和由此产生的软件， mDOT附属机构。最后，统一的mDOT管理核心和优化的操作程序将有助于 TR&D研究人员及其相关CP和SP之间的互动;评估生产力和影响力 集中活动;并提供持续的管理、监督和规划。 1

Primary Investigator: Kumar, Santosh mHealth Center for Discovery, Optimization & Translation of Temporally-Precise Interventions (mDOT) – Overall Abstract: Providing care for patients with chronic diseases is one of the biggest drivers of the nation’s rising healthcare spending. Many of these diseases are inextricably linked to mutable health behaviors such as poor diet, lack of physical activity, and smoking. A key strategy for making self-care and preventive health behaviors more achievable has been the integration of passive monitoring into everyday life via mobile sensors and providing personalized information and guidance to patients. But, to have the maximum long-term efficacy, such mHealth interventions must be delivered at the most opportune moment and its content must be dynamically personalized to the individual, their current context, and changing preferences. Our proposed mHealth Center for Discovery, Optimization & Translation of Temporally-Precise Interventions (the mDOT Center) will provide the methods, tools, and infrastructure for researchers to discover, optimize and deploy temporally-precise mHealth interventions. Organized around three Technology Research & Development (TR&D) projects, mDOT represents a unique national resource that will develop multiple methodological and technological innovations, including easily deployable wearables, apps for wearables and smartphones, and a companion mHealth cloud system, all open-source. TR&D1 will develop, evaluate and disseminate methods to analyze population-scale multi-modal time series of mHealth biomarkers to identify the momentary risk factors and risk dynamics that drive adverse health outcomes, while accounting for the uncertainty and missingness inherent in these data sources. TR&D2 will develop new reinforcement learning methods to personalize the selection and delivery of mHealth interventions to individuals at their own optimal times and locations so as to maintain user engagement and provide precise and maximal health benefits. TR&D3 will develop, validate and disseminate algorithms, tools and software/hardware designs that will enable large-scale deployment of resource-efficient, real-time, low-latency and privacy-aware digital biomarkers. Together, these mDOT deliverables will transform the ability of researchers and innovators to exploit the exploding range of sensors and mobile technologies to develop and deliver dynamically personalized and temporally-precise mHealth interventions to individuals. The iterative “push-pull” interaction with collaborative projects (CP) and direct dissemination to service projects (SP’s) will ensure that the technologies developed by our TR&Ds’ solve real- world problems, are usable by other researchers, and will have the broadest impact. The mDOT Center’s training and dissemination (T&D) activities will seek to maximize the societal impact of our technologies by promoting broad distribution and uptake of mDOT technologies and resulting software beyond mDOT affiliates. Finally, a unifying mDOT administrative core and optimized operating procedures will facilitate interactions among TR&D researchers and their associated CPs and SPs; assess the productivity and impact of Center activities; and provide ongoing management, oversight, and planning. 1