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The central amygdala circuits in motivated behaviors

动机行为中的中央杏仁核回路

基本信息

批准号：
10543115
负责人：
Linda Van Aelst
金额：
$ 70.96万
依托单位：
COLD SPRING HARBOR LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-03-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10543115
关键词：
Amygdaloid structure Anxiety Anxiety Disorders Appetitive Behavior Area Aversive Stimulus Behavior Behavioral Brain Cell physiology Clinical Data Desire for food Disease Disinhibition Dopamine Drug Addiction Dynorphins Educational process of instructing Environment Fiber Fright Functional disorder Generations Genetic Genetic Markers Goals Human Impairment Knowledge Learning Measures Mental Depression Moods Motivation Mus Neurons Neuropeptides Pathway interactions Pharmaceutical Preparations Photometry Play Population Process Property Protein Kinase C Punishment Regulation Research Rewards Role Signal Transduction Somatostatin Stimulus Stress Structure Structure of terminal stria nuclei of preoptic region System Techniques Testing anxiety states anxiety-related behavior avoidance behavior behavioral response cell type cholinergic conditioned fear improved in vivo in vivo imaging insight motivated behavior neuromechanism neuroregulation novel optogenetics programs response sensor

项目摘要

The central amygdala circuits in motivated behaviors Project Summary The central amygdala (CeA) contains heterogeneous cell types, with somatostatin-expressing (SOM+) neurons and protein kinase C--expressing (PKC-+) neurons being two largest and largely non-overlapping populations. Previous studies have mainly focused on the roles of these neurons in fear conditioning, revealing that SOM+ and PKC-+ CeA neurons differentially contribute to fear learning and expression. However, it is long recognized that the CeA contributes not only to behaviors driven by aversive stimuli, but also to those driven by appetitive stimuli, and to the generation of anxiety state. Indeed, recent studies show that distinct types of CeA neurons, such as SOM+ neurons, can drive appetitive behaviors and heightened anxiety. However, how the SOM+ as well as PKC-+ CeA neurons participate in divergent motivational behaviors remains poorly understood. Bridging this knowledge gap will have important clinical implications for improved treatments, as CeA dysfunctions have been implicated in mood- or motivation-related disorders, including anxiety disorders, depression and drug addiction. We will address this question by investigating the in vivo response properties of SOM+ neurons and PKC-+ neurons in the CeA during behaviors driven by either reward or punishment, and determining how these responses are used to control the functions of downstream circuits and, hence, behavior. Our central hypothesis is that CeA neurons influence learning or expression of reward seeking and punishment avoidance through their long-range projections to different targets. Based on our preliminary results, we devised an integrated approach, combining in vivo imaging, fiber photometry, optogenetics, chemogenetics and novel behavioral techniques, to test our hypotheses in the following Specific Aims: Aim 1. To determine the roles of SOM+ CeA neurons in motivational behaviors. Aim 2. To determine the roles of PKC-+ CeA neurons in motivational behaviors. Aim 3. To determine how a CeA-BNST circuit contributes to anxiety-related behaviors.

动机行为中的杏仁核中央回路