Administrative Core

行政核心

• 批准号: 10549476
• 负责人: Viviana A Simon
• 金额: $ 25.35万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-21 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10549476
• 关键词: Achievement; Animal Model; Antibodies; B-Lymphocytes; COVID-19 pandemic; Collaborations; Communication; Coronavirus; Coronavirus Infections; Coronavirus spike protein; Data; Databases; Decision Making; Ensure; Environment; Evaluation; Goals; Humoral Immunities; Immune; Immune response; Immunity; Immunologist; Infection; Infrastructure; Institution; Interdisciplinary Study; Laboratories; Leadership; Manuscripts; Monitor; Monoclonal Antibodies; National Institute of Allergy and Infectious Disease; Occupational activity of managing finances; Office of Administrative Management; Pennsylvania; Performance; Philadelphia; Physicians; Policies; Pre-Clinical Model; Preparation; Principal Investigator; Procedures; Progress Reports; Public Health; Reagent; Recombinants; Recording of previous events; Reporting; Research; Research Institute; Research Personnel; Research Project Grants; Resource Allocation; Resource Sharing; Resources; Sampling; Sarbecovirus; Scientist; Services; Specificity; Strategic Planning; Structural Biologist; Transfer Agreement; United States National Institutes of Health; Universities; Vaccination; Vaccines; Variant; Viral; Washington; betacoronavirus vaccine; conflict resolution; coronavirus vaccination; cost; cross reactivity; dashboard; data access; data harmonization; data management; data quality; design; efficacy evaluation; efficacy testing; experimental study; flexibility; future pandemic; human model; imprint; material transfer agreement; medical schools; meetings; multidisciplinary; pandemic coronavirus; programs; quality assurance; response; risk mitigation; seasonal coronavirus; social media; symposium; synergism; vaccine candidate; vaccine development; ward; web page; zoonotic coronavirus

The SARS-CoV-2 pandemic represents an exceptional public health crisis highlighting the need for better understanding of the mechanisms controlling broadly protective immune responses and generating vaccine candidates able to elicit such responses. The program project entitled “Programming Long-lasting Immunity to Coronaviruses (PLUTO)” proposes a comprehensive research plan towards designing pan- sarbecovirus and pan-betacoronavirus vaccines with broad protection by applying in-depth B cell characterization in the context of coronavirus immune histories imprinted by successive vaccinations and/or infections. Two complementary research projects will establish correlates of robust, durable and protective coronavirus humoral immunity (Project 1) as well as design and test efficacy of viral variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. The Administrative Core led by one of the two Principal Investigators, Dr. Viviana Simon, will function as a coordinating hub of the program providing a strong overall administrative infrastructure. The proposed activities and services of the Administrative Core are to provide overall management and program coordination, to facilitate communication within the program, to monitor progress within the projects and to prioritize, allocate, and manage resources. It will also support cooperation between the Research Projects and Service Cores by putting in place transfer agreements, data management plans and conflict resolution procedures. The Antibody Core will develop a large panel of recombinant monoclonal antibodies (mAbs) against coronavirus spike proteins to aid in defining specificity of immune responses elicited by coronavirus infection and/or vaccination in humans and animal models. The Animal Model Core will provide a central resource with approvals, facilities, and expertise to assess efficacy of broadly cross-reactive coronavirus antibodies and vaccines in robust pre-clinical models against a spectrum of coronaviruses, including Select Agents. A multidisciplinary team of scientists from five institutions who have an outstanding track record of working collaboratively will conduct the proposed studies. The Research Projects will collaborate across projects and with the Antibody and Animal Model Cores, coordinated by the Administrative Core. The integrated and synergistic activities across Projects and Cores will drive successful completion of the program project's ambitious research agenda, enabling achievement of the long-term PLUTO goal of developing variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. These findings will contribute to curbing the current SARS-CoV-2 pandemic and mitigate the risk of future pandemics with coronaviruses.

SARS-CoV-2大流行是一场特殊的公共卫生危机，突出表明需要 更好地了解控制广泛保护性免疫反应的机制， 能够引起这种反应的候选疫苗。题为“持久方案拟订”的方案项目 免疫冠状病毒（PLUTO）”提出了一个全面的研究计划，旨在设计泛- 通过应用深层B细胞具有广泛保护的肉瘤病毒和泛β冠状病毒疫苗 在冠状病毒免疫历史背景下的连续疫苗接种特征 和/或感染。两个互补的研究项目将建立强大的，持久的 和保护性冠状病毒体液免疫（项目1）以及病毒的设计和测试功效 抗变异泛肉瘤病毒和泛β冠状病毒疫苗。行政核心由一位 两位首席研究员薇薇安娜·西蒙博士将作为该项目的协调中心 提供强大的整体行政基础设施。拟议的活动和服务 行政核心是提供全面管理和计划协调，以促进 项目内部的沟通，以监控项目的进度，并确定优先级，分配， 管理资源。它还将支持研究项目和服务核心之间的合作， 制定转让协议、数据管理计划和冲突解决程序。的 Antibody Core将开发一大批针对冠状病毒的重组单克隆抗体（mAb） 刺突蛋白，以帮助定义冠状病毒感染引起的免疫应答的特异性，和/或 在人类和动物模型中接种疫苗。动物模型核心将提供一个中央资源， 批准、设施和专业知识，以评估广泛交叉反应的冠状病毒抗体的效力， 在针对一系列冠状病毒（包括Select Agents）的稳健临床前模型中使用疫苗。一 来自五个机构的多学科科学家团队，他们在以下方面有着出色的工作记录： 将共同开展拟议的研究。研究项目将在 项目和抗体和动物模型核心，由行政协调 核心跨项目和核心的综合和协同活动将推动成功 完成该计划项目雄心勃勃的研究议程，实现长期目标 PLUTO的目标是开发防变异的泛肉瘤病毒和泛β冠状病毒疫苗。这些 研究结果将有助于遏制目前的SARS-CoV-2大流行，并减轻未来的风险。 冠状病毒的大流行。