Administrative Core

SARS-CoV-2大流行是一场特殊的公共卫生危机，突显了 更好地理解控制广泛保护性免疫反应和产生 能够引起这种反应的候选疫苗。题为《编程持久》的方案项目 对冠状病毒的免疫(冥王星)“提出了一个全面的研究计划，以设计泛 深度B细胞广泛保护的肉瘤病毒和泛-贝塔冠状病毒疫苗 在连续接种疫苗的冠状病毒免疫史背景下的特征 和/或感染。两个互补的研究项目将建立健壮、持久的 和保护性冠状病毒体液免疫(项目1)以及病毒的设计和测试效果 抗变异的泛肉瘤病毒和泛贝塔冠状病毒疫苗。由以下其中之一领导的行政核心 两名首席调查员Viviana Simon博士将担任该项目的协调中心 提供强大的整体行政基础设施。建议的活动和服务 行政核心是提供全面的管理和计划协调，以促进 在计划内进行沟通，以监控项目内的进展，并确定优先顺序、分配和 管理资源。它还将通过以下方式支持研究项目和服务核心之间的合作 制定转让协议、数据管理计划和冲突解决程序。这个 抗体核心将开发一大批针对冠状病毒的重组单抗(MAbbs) 尖峰蛋白有助于确定冠状病毒感染和/或引起的免疫反应的特异性 在人类和动物模型中接种疫苗。动物模型核心将提供一个中央资源，包括 批准，设施和专业知识，以评估广泛交叉反应冠状病毒抗体和 在强大的临床前模型中针对包括选择试剂在内的一系列冠状病毒的疫苗。一个 由来自五个机构的多学科科学家组成的团队，他们有出色的工作记录 将合作进行拟议的研究。研究项目将在以下方面进行合作 以抗体和动物模型为核心的项目，由行政部门协调 核心。跨项目和核心的综合和协同活动将推动成功 完成方案项目雄心勃勃的研究议程，使长期目标得以实现 冥王星的目标是开发抗变异的泛肉瘤病毒和泛贝塔冠状病毒疫苗。这些 这些发现将有助于遏制目前的SARS-CoV-2大流行，并降低未来的风险 冠状病毒大流行。

The SARS-CoV-2 pandemic represents an exceptional public health crisis highlighting the need for better understanding of the mechanisms controlling broadly protective immune responses and generating vaccine candidates able to elicit such responses. The program project entitled “Programming Long-lasting Immunity to Coronaviruses (PLUTO)” proposes a comprehensive research plan towards designing pan- sarbecovirus and pan-betacoronavirus vaccines with broad protection by applying in-depth B cell characterization in the context of coronavirus immune histories imprinted by successive vaccinations and/or infections. Two complementary research projects will establish correlates of robust, durable and protective coronavirus humoral immunity (Project 1) as well as design and test efficacy of viral variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. The Administrative Core led by one of the two Principal Investigators, Dr. Viviana Simon, will function as a coordinating hub of the program providing a strong overall administrative infrastructure. The proposed activities and services of the Administrative Core are to provide overall management and program coordination, to facilitate communication within the program, to monitor progress within the projects and to prioritize, allocate, and manage resources. It will also support cooperation between the Research Projects and Service Cores by putting in place transfer agreements, data management plans and conflict resolution procedures. The Antibody Core will develop a large panel of recombinant monoclonal antibodies (mAbs) against coronavirus spike proteins to aid in defining specificity of immune responses elicited by coronavirus infection and/or vaccination in humans and animal models. The Animal Model Core will provide a central resource with approvals, facilities, and expertise to assess efficacy of broadly cross-reactive coronavirus antibodies and vaccines in robust pre-clinical models against a spectrum of coronaviruses, including Select Agents. A multidisciplinary team of scientists from five institutions who have an outstanding track record of working collaboratively will conduct the proposed studies. The Research Projects will collaborate across projects and with the Antibody and Animal Model Cores, coordinated by the Administrative Core. The integrated and synergistic activities across Projects and Cores will drive successful completion of the program project's ambitious research agenda, enabling achievement of the long-term PLUTO goal of developing variant-proof pan-sarbecovirus and pan-betacoronavirus vaccines. These findings will contribute to curbing the current SARS-CoV-2 pandemic and mitigate the risk of future pandemics with coronaviruses.