Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention products
指导和研究,为新型 HIV 预防产品准备口服 PrEP 递送平台
基本信息
- 批准号:10548809
- 负责人:
- 金额:$ 14.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-01 至 2025-12-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAdherenceAfricaAfricanAfrican American populationAwardBehavioral SciencesClinicalClinical ResearchCognitiveCommunicable DiseasesCommunitiesCounselingDapivirineDoctor of PhilosophyDoseEpidemiologistEpidemiologyEvaluationFacultyFemaleFundingGrantHIVHIV InfectionsHIV riskHomeHourIncidenceInjectableInternationalInterviewKenyaLesothoManuscriptsMentorsMethodsModalityOralPersonsPhase III Clinical TrialsPostdoctoral FellowPreparationPrevention ResearchProviderQualitative ResearchReproductive HealthResearchResearch AssistantResearch PersonnelSafetyScienceScientistSouth AfricaStructureTenofovirTimeTrainingTranslational ResearchUgandaUnderrepresented PopulationsUnited States National Institutes of HealthUniversitiesVaginal RingVisionWashingtonWomanWorkWritingcareerdesigndoctoral studentexperienceexperimental studyglobal healthimplementation researchimplementation scienceinformantmeetingsmid-career facultynext generationnovelpatient oriented researchphase III trialpillpre-doctoralpre-exposure prophylaxispreferenceprogramsside effectskillssocialtheoriesuptakeyoung woman
项目摘要
ABSTRACT
This is a career mentoring award to support Dr. Renee Heffron, Associate Professor at the University of
Washington, with protected time to create a more structured approach to mentoring for herself and her
colleagues and to increase the number of mentees that she has by at least 50%. Mentees will be among the
next generation of researchers focused on HIV prevention, oral pre-exposure prophylaxis (PrEP), and novel
PrEP products. Dr. Heffron, PhD, MPH is a clinical epidemiologist with advanced training in implementation
science, behavioral science, and qualitative research. Dr. Heffron's mentoring style is grounded in the Social
Cognitive Career Theory and includes emphasis on developing mentee's science identify. Mentees will work
alongside Dr. Heffron on the newly proposed research in the K24 in the realm of implementation science as well
as on her four ongoing NIH-funded studies in Uganda, Kenya, and South Africa.
Mentoring aims are to:
1. Support and grow the next generation of US- and Africa-based leaders conducting patient-oriented research
focused on delivery of oral PrEP and novel PrEP products through the provision of structured mentoring to
a total of 20-40 (~5 new mentees/year) pre-doctoral students, postdoctoral fellows, junior faculty, and other
junior investigators, including subsets who are female and identify as being from URG.
2. Establish and refine a structured mentoring program within the International Clinical Research Center, my
research home within the University of Washington Department of Global Health.
Newly proposed research provides opportunity for Dr. Heffron to grow her repertoire of work in implementation
science, in order to identify best practices to integrate novel PrEP products into existing platforms for oral PrEP
delivery by conducting 60 key informant qualitative interviews with experts developing novel PrEP products,
PrEP program implementers, and end users who discontinued or rejected use of oral PrEP. A discrete choice
experiment will be conducted with young women in Uganda to identify their preferences for different attributes of
HIV prevention counseling and whether counseling scenarios would facilitate uptake of a PrEP product.
Research specific aims are to:
1. Define a preliminary strategy for the integration of novel PrEP products (e.g., injectable Cabotegravir,
Dapivirine intravaginal ring, TFV/LNG intravaginal ring) into existing oral PrEP programs by conducting
qualitative interviews with experts in novel PrEP products, oral PrEP programs, and end users
2. Among young women who have discontinued or never initiated oral PrEP, to determine preferences for
attributes of HIV prevention counseling that would support them to initiate and sustain use of a PrEP product
摘要
这是一个职业指导奖,以支持博士蕾妮Heffron,副教授在大学
华盛顿,有保护的时间来创建一个更有条理的方法来指导她自己和她的孩子。
她还希望能够增加她的同事,并将她的学员人数增加至少50%。其中,
下一代研究人员专注于艾滋病毒预防,口服暴露前预防(PrEP)和新的
PrEP产品。Heffron博士,PhD,MPH是一位临床流行病学家,在实施方面接受过高级培训
行为科学和定性研究。Heffron的指导风格是在社会接地
认知生涯理论,包括强调发展学员的科学身份。学员将工作
与Heffron博士一起研究K24在实施科学领域的新研究
正如她在乌干达、肯尼亚和南非正在进行的四项由NIH资助的研究一样。
指导的目的是:
1.支持和发展下一代美国和非洲领导人进行以患者为导向的研究
专注于通过提供结构化指导提供口服PrEP和新型PrEP产品,
总共有20-40名(约5名新学员/年)博士前学生,博士后研究员,初级教师和其他
初级研究者,包括来自URG的女性亚组。
2.在国际临床研究中心内建立并完善结构化的指导计划,
华盛顿大学全球健康系的研究之家。
新提出的研究为Heffron博士提供了在实施中发展她的工作曲目的机会
科学,以确定将新型PrEP产品整合到现有口服PrEP平台的最佳实践
通过与开发新型PrEP产品的专家进行60次关键知情人定性访谈,
PrEP计划实施者以及停止或拒绝使用口服PrEP的最终用户。一个离散的选择
将在乌干达的年轻妇女中进行实验,以确定她们对不同属性的偏好,
艾滋病毒预防咨询以及咨询方案是否有助于PrEP产品的吸收。
研究的具体目标是:
1.为新型PrEP产品的整合制定初步策略(例如,注射用卡博特拉韦,
达匹韦林阴道环,TFV/LNG阴道环)纳入现有的口服PrEP计划,
对新型PrEP产品、口服PrEP计划和最终用户的专家进行定性访谈
2.在已经停止或从未开始口服PrEP的年轻女性中,
艾滋病毒预防咨询的属性,将支持他们开始和持续使用PrEP产品
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Renee A. Heffron其他文献
Renee A. Heffron的其他文献
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{{ truncateString('Renee A. Heffron', 18)}}的其他基金
Effectiveness of PrEP product choice on HIV prevention coverage among young women in Kenya seeking reproductive health services
PrEP 产品选择对寻求生殖健康服务的肯尼亚年轻女性艾滋病毒预防覆盖率的有效性
- 批准号:
10761048 - 财政年份:2023
- 资助金额:
$ 14.76万 - 项目类别:
Implementation science research on PrEP delivery and costing within MAT andNSP services for PWUD in Uganda
乌干达残疾人士 MAT 和 NSP 服务中 PrEP 交付和成本计算的实施科学研究
- 批准号:
10744381 - 财政年份:2022
- 资助金额:
$ 14.76万 - 项目类别:
Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention products
指导和研究,为新型 HIV 预防产品准备口服 PrEP 递送平台
- 批准号:
10642471 - 财政年份:2022
- 资助金额:
$ 14.76万 - 项目类别:
Implementation science research on PrEP delivery and costing within MAT andNSP services for PWUD in Uganda
乌干达残疾人士 MAT 和 NSP 服务中 PrEP 交付和成本计算的实施科学研究
- 批准号:
10631694 - 财政年份:2022
- 资助金额:
$ 14.76万 - 项目类别:
Implementation science research on PrEP delivery and costing within MAT andNSP services for PWUD in Uganda
乌干达残疾人士 MAT 和 NSP 服务中 PrEP 交付和成本计算的实施科学研究
- 批准号:
10684112 - 财政年份:2022
- 资助金额:
$ 14.76万 - 项目类别:
Mentoring and research to prepare oral PrEP delivery platforms for novel HIV prevention products
指导和研究,为新型艾滋病毒预防产品准备口服 PrEP 递送平台
- 批准号:
10322040 - 财政年份:2021
- 资助金额:
$ 14.76万 - 项目类别:
Feasibility pilot of home-based STI testing and risk self-assessment among adolescent girls in South Africa to trigger PrEP re-start
在南非少女中进行家庭性传播感染检测和风险自我评估以触发 PrEP 重新启动的可行性试点
- 批准号:
10678858 - 财政年份:2021
- 资助金额:
$ 14.76万 - 项目类别:
Feasibility pilot of home-based STI testing and risk self-assessment among adolescent girls in South Africa to trigger PrEP re-start
在南非少女中进行家庭性传播感染检测和风险自我评估以触发 PrEP 重新启动的可行性试点
- 批准号:
10256147 - 财政年份:2021
- 资助金额:
$ 14.76万 - 项目类别:
Feasibility pilot of home-based STI testing and risk self-assessment among adolescent girls in South Africa to trigger PrEP re-start
在南非少女中进行家庭性传播感染检测和风险自我评估以触发 PrEP 重新启动的可行性试点
- 批准号:
10478163 - 财政年份:2021
- 资助金额:
$ 14.76万 - 项目类别:
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