Mentoring and research to prepare oral PrEP delivery platforms for novel HIVprevention products

指导和研究，为新型 HIV 预防产品准备口服 PrEP 递送平台

• 批准号: 10548809
• 负责人: Renee A. Heffron
• 金额: $ 14.76万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10548809
• 关键词: AIDS prevention; Adherence; Africa; African; African American population; Award; Behavioral Sciences; Clinical; Clinical Research; Cognitive; Communicable Diseases; Communities; Counseling; Dapivirine; Doctor of Philosophy; Dose; Epidemiologist; Epidemiology; Evaluation; Faculty; Female; Funding; Grant; HIV; HIV Infections; HIV risk; Home; Hour; Incidence; Injectable; International; Interview; Kenya; Lesotho; Manuscripts; Mentors; Methods; Modality; Oral; Persons; Phase III Clinical Trials; Postdoctoral Fellow; Preparation; Prevention Research; Provider; Qualitative Research; Reproductive Health; Research; Research Assistant; Research Personnel; Safety; Science; Scientist; South Africa; Structure; Tenofovir; Time; Training; Translational Research; Uganda; Underrepresented Populations; United States National Institutes of Health; Universities; Vaginal Ring; Vision; Washington; Woman; Work; Writing; career; design; doctoral student; experience; experimental study; global health; implementation research; implementation science; informant; meetings; mid-career faculty; next generation; novel; patient oriented research; phase III trial; pill; pre-doctoral; pre-exposure prophylaxis; preference; programs; side effect; skills; social; theories; uptake; young woman

ABSTRACT This is a career mentoring award to support Dr. Renee Heffron, Associate Professor at the University of Washington, with protected time to create a more structured approach to mentoring for herself and her colleagues and to increase the number of mentees that she has by at least 50%. Mentees will be among the next generation of researchers focused on HIV prevention, oral pre-exposure prophylaxis (PrEP), and novel PrEP products. Dr. Heffron, PhD, MPH is a clinical epidemiologist with advanced training in implementation science, behavioral science, and qualitative research. Dr. Heffron's mentoring style is grounded in the Social Cognitive Career Theory and includes emphasis on developing mentee's science identify. Mentees will work alongside Dr. Heffron on the newly proposed research in the K24 in the realm of implementation science as well as on her four ongoing NIH-funded studies in Uganda, Kenya, and South Africa. Mentoring aims are to: 1. Support and grow the next generation of US- and Africa-based leaders conducting patient-oriented research focused on delivery of oral PrEP and novel PrEP products through the provision of structured mentoring to a total of 20-40 (~5 new mentees/year) pre-doctoral students, postdoctoral fellows, junior faculty, and other junior investigators, including subsets who are female and identify as being from URG. 2. Establish and refine a structured mentoring program within the International Clinical Research Center, my research home within the University of Washington Department of Global Health. Newly proposed research provides opportunity for Dr. Heffron to grow her repertoire of work in implementation science, in order to identify best practices to integrate novel PrEP products into existing platforms for oral PrEP delivery by conducting 60 key informant qualitative interviews with experts developing novel PrEP products, PrEP program implementers, and end users who discontinued or rejected use of oral PrEP. A discrete choice experiment will be conducted with young women in Uganda to identify their preferences for different attributes of HIV prevention counseling and whether counseling scenarios would facilitate uptake of a PrEP product. Research specific aims are to: 1. Define a preliminary strategy for the integration of novel PrEP products (e.g., injectable Cabotegravir, Dapivirine intravaginal ring, TFV/LNG intravaginal ring) into existing oral PrEP programs by conducting qualitative interviews with experts in novel PrEP products, oral PrEP programs, and end users 2. Among young women who have discontinued or never initiated oral PrEP, to determine preferences for attributes of HIV prevention counseling that would support them to initiate and sustain use of a PrEP product

摘要 这是一个职业指导奖，以支持芝加哥大学副教授Renee Heffron博士 华盛顿，有保护的时间为她和她自己创造一种更有条理的指导方法 并将她的指导对象数量增加至少50%。受训者将是 下一代研究人员专注于艾滋病毒预防、接触前口服预防(PrEP)和新型 预科产品。Heffron博士，公共卫生硕士，临床流行病学家，在实施方面受过高级培训。 科学、行为科学和定性研究。赫夫龙博士的指导风格植根于 认知职业生涯理论，包括强调培养被辅导者的科学认同感。学员将发挥作用 与Heffron博士一起讨论K24在实现科学领域的最新拟议研究 就像她在乌干达、肯尼亚和南非进行的四项由NIH资助的研究一样。 指导的目标是： 1.支持和培养美国和非洲的下一代领导人开展以患者为中心的研究 通过提供结构化的指导，重点提供口腔PrEP和新型PrEP产品 共有20-40名博士后研究生、博士后研究员、初级教员和其他人员 初级调查人员，包括女性，并确认为来自URG。 2.在我的国际临床研究中心内建立和完善结构化的指导计划 华盛顿大学全球卫生系的研究中心。 新提出的研究为Heffron博士提供了机会来扩大她在实施中的工作范围 科学，以确定将新的PrEP产品整合到现有的口腔PrEP平台的最佳做法 通过对开发新PrEP产品的专家进行60次关键线人定性访谈进行交付， 预备计划实施者，以及停止或拒绝使用口服PrEP的最终用户。慎重的选择 将在乌干达的年轻女性中进行实验，以确定她们对不同属性的偏好 艾滋病毒预防咨询，以及咨询情景是否会促进PrEP产品的接受。 研究的具体目标是： 1.定义用于整合新型PrEP产品的初步策略(例如，可注射卡波替格韦， 达匹韦林阴道内环、TFV/LNG阴道内环)通过进行 对新型PrEP产品、口头PrEP计划和最终用户的专家进行定性访谈 2.在已经停止或从未开始口服PrEP的年轻女性中，确定对 支持他们开始和持续使用PrEP产品的艾滋病毒预防咨询的属性