Administrative Core

行政核心

• 批准号: 10546505
• 负责人: Karel Svoboda
• 金额: $ 36.75万
• 依托单位: ALLEN INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-15 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10546505
• 关键词: Achievement; Adherence; Adopted; Adoption; Anatomy; Architecture; Area; Authorship; Behavior; Behavioral; Budgets; Collaborations; Communication; Communities; Computer software; Data; Data Analyses; Data Science Core; Electrophysiology (science); Ensure; Feedback; Fostering; Generations; Goals; Image; Individual; Industry; Infrastructure; Institution; Joints; Leadership; Life Cycle Stages; Logic; Manuscripts; Maps; Modernization; Molecular; Monitor; Neurosciences; New York; Performance; Phase; Procedures; Process; Production; Progress Reports; Publications; Quality Control; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk Management; Role; Route; Science; Shapes; Signal Transduction; Site; Software Tools; Standardization; Strategic Planning; Structure; Synapses; Thalamic structure; Time; Universities; cell type; cloud based; computational network modeling; computerized data processing; conflict resolution; data exchange; data integration; data quality; data resource; data sharing; data standards; density; design; experience; frontal lobe; member; multimodal data; neural; neural circuit; neurophysiology; optogenetics; organizational structure; programs; repository; software development; synergism; theories; tool

Summary, Administrative Core The proposal “Thalamus in the middle: computations in multi-regional neural circuits” aims to combine expertise in theory, molecular neuroscience, modern high-throughput anatomy, cellular and synaptic neurophysiology, and large-scale neurophysiology in the context of quantitative behavior. The overall project consists of five Projects, focusing on how information flows from subcortical areas, through thalamus, to control cortical activity modes and thereby shape behavior; a Molecular Science Core, a Data Science Core, and an Administrative Core with 5 PIs and two collaborative sites. Realizing the potential of this project requires strong administrative leadership to integrate and synergize efforts across the collaborating researchers at New York University and the Allen Institute. The Administrative Core will provide the structure, leadership and operational management of the overall project to advance the goal of understanding neural computation in subcortex → thalamus → cortex circuits. This will include project management, strategic planning, progress reporting, fiscal management, and support for collaboration and communication. The Administrative Core will create an infrastructure that fosters communication and collaboration among the members, as well as garnering input from the external research community through the formation of an External Scientific Advisory Board. The overall project will form a Steering Committee and Project Teams to oversee the collaborative, standardized, and on-time data generation, data analysis, and public data sharing process. Project management best practices, such as milestones, progress reporting and tracking, collaborative software programs, and a responsibility matrix will be applied to ensure achievement of performance objectives and milestones, optimized communication, and resource utilization and prioritization. In addition, the Administrative Core will foster joint data analysis efforts across projects and Institutions. To produce a high-quality tools and data resource, rigorous standardization and quality control practices will be adopted by all members. Finally, the Administrative Core will implement and maintain fiscal and subcontractor management processes for all members, manage publication and authorship decisions and conflict resolution. With the implementation of this entire infrastructure, we anticipate that this project and the resources it produces will have a broad and meaningful impact on uncovering the logic of signal routing from subcortical areas to the frontal cortex thalamus.

摘要，行政核心 “中间的丘脑：多区域神经回路中的计算”提案旨在将联合收割机的专业知识 在理论上，分子神经科学，现代高通量解剖学，细胞和突触神经生理学， 定量行为背景下的大规模神经生理学。整个项目包括五个项目， 重点研究信息如何从皮层下区域通过丘脑流动，以控制皮层活动模式 从而塑造行为;分子科学核心，数据科学核心和管理核心， 5个PI和2个协作站点。实现这一项目的潜力需要强有力的行政领导 整合并协同纽约大学和艾伦大学的合作研究人员的努力， 院 行政核心将提供整个项目的结构、领导和业务管理 推进理解皮层下→丘脑→皮层回路中的神经计算的目标。这将 包括项目管理、战略规划、进度报告、财务管理和对 协作和沟通。行政核心将建立一个基础设施， 成员之间的沟通和合作，以及从外部研究中获得投入 通过组建外部科学咨询委员会，为社区提供支持。整个项目将形成一个指导 委员会和项目团队负责监督协作、标准化和及时的数据生成， 分析和公共数据共享过程。项目管理最佳实践，如里程碑、进度 报告和跟踪、协作软件程序和责任矩阵将被应用，以确保 绩效目标和里程碑的实现、优化沟通和资源利用， 优先化。此外，行政核心将促进各项目的联合数据分析工作， 机构职能体系制作出高质量的工具和数据资源，严格的标准化和质量控制 所有成员都将采用这种做法。最后，行政核心将执行和维持财政和 所有成员的分包商管理流程，管理出版和作者决定， 解决冲突。随着整个基础设施的实施，我们预计该项目和 它产生的资源将对揭示信号路由逻辑产生广泛而有意义的影响， 皮层下区域到额叶皮层丘脑。