SARS-CoV-2 in Correctional Populations: A collaborative, ethical approach to application of wastewater-based surveillance

在美国的COVID19大流行期间，监狱中的人患上的疾病比例是原来的3倍或更多 比在普通人群中看到的要多。虽然许多病例是从周围社区输入的， 这些聚集环境中的拥挤导致了快速的内部传播，特别是在监狱里的检测已经 已经很稀疏了。工作人员和被拘留的人对疫苗的犹豫不决意味着人口对新一轮疫情的准备不足 感染的可能性，可能来自病毒变种。更好的监控可以更早地向系统发出警告，并允许监狱阻止 新一轮疫情的浪潮。至少一半，如果不是更多的感染者，会在他们的粪便中释放冠状病毒。 监测废水是一种很有前途的做法，只有少数监狱采用了这种做法。我们的首要目标是 引入或改进污水监测(WBS)作为SARS-CoV-2的循证策略 对亚特兰大、芝加哥、波士顿郊区和华盛顿特区监狱的监控。我们将根据需要对其进行调整 评估监狱环境，并利用执行研究综合框架评估执行情况。 执行小组将由惩教人员和以前被监禁的个人组成。我们的目标是： (1)评估在4所监狱实施SARS-CoV-2检测工作的障碍和推动者 演示点。在CFIR的指导下，我们举办了一次信息网络研讨会，然后进行专题小组讨论。四个遗嘱 与每个监狱的领导会面；他们将讨论引入WBS的特定地点背景或 精致的。第五个跨站点的监狱工作人员焦点小组，以及第六个跨站点的监狱工作人员小组 经验将反映WBS方法的特点和监狱环境中的实施战略。 (2)衡量与WBS相关的实施成果，并利用这些成果向关键 利益攸关方，使用知识转化为行动的框架。我们将研究吸收、可接受性、适当性和 WBS作为敏感预警系统和量化SARS-CoV-2水平监测的可行性 柯萨奇病毒19流行趋势。可行性，即如何对WBS数据采取行动的适宜性，将是最重要的 重要性。我们将使用知识转化为行动的流程模式，利用实施成果来进一步 让利益相关者参与，并描述在监狱中成功实施WBS所需的适应特征。 (3，试点)研究纳入不同利益攸关方的过程和公认的有效性，包括 之前被监禁的人，在WBS实施小组。我们将使用研究参与度调查工具 (REST)，在实施进程的早期和八个月后调查个人关于实施的情况 有过监狱生活经历的团队；所有其他同意的实施团队成员将接受一次调查 在实施过程的早期。 成功完成这些目标将决定推动WBS实施以改善疾病的因素 监狱里的监控。通过将最近出狱的人纳入执行小组，我们希望 让研究人员和政策制定者了解实施过程中的道德规范和协作过程。

Throughout the COVID19 pandemic in the U.S., persons in jails have borne a share of disease 3-fold or greater than that seen in the general population. While many cases have been imported from surrounding communities, crowding in these congregate settings has led to rapid in-house transmission, especially since testing in jails has been sparse. Vaccine hesitancy among staff and those detained mean the population is ill prepared for new waves of infection, perhaps from virus variants. Better surveillance could warn systems earlier, and allow jails to stem the tide of a new outbreak. At least half, if not more, of infected persons shed coronavirus in their stool. Monitoring wastewater is a promising practice that only a few jails have adopted. Our overarching goal is to introduce or refine Wastewater Based Surveillance (WBS) as an evidence-based strategy for SARS-CoV-2 surveillance in the jails of Atlanta, Chicago, suburban Boston and Washington DC. We will adapt it to the needs of jail settings and evaluate the implementation with the Consolidated Framework for Implementation Research. Implementation teams will be formed of both correctional staff and formerly incarcerated individuals. Our aims: (1) To assess the barriers to and facilitators of implementing WBS for SARS-CoV-2 detection in 4 jail demonstration sites. Guided by CFIR, we hold an informational webinar, then conduct focus groups. Four will be with leaders at each of the jails; these will discuss the site-specific context in which WBS will be introduced or refined. A fifth, cross-site focus group of jail workers, and a sixth, cross-site group of persons with lived jail experience, will reflect on characteristics of WBS approaches and implementation strategies in jail settings. (2) To measure implementation outcomes associated with WBS and use these outcomes to inform key stakeholders, using a knowledge to action framework. We will study uptake, acceptability, appropriateness and feasibility of WBS as a sensitive early warning system and a way of quantifying SARS-CoV-2 levels to monitor trends in COVID19 prevalence. Feasibility, the suitability of how WBS data are acted upon, will be of utmost importance. We will use the Knowledge to Action process model, leveraging implementation outcomes to further engage stakeholders and characterize the adaptions needed to successfully implement WBS in jails. (3, Pilot) To study the process and the perceived effectiveness of incorporating diverse stakeholders, including the formerly incarcerated, on the WBS implementation team. We will use the Research Engagement Survey Tool (REST), to survey early in the implementation process and eight months later, individuals on the implementation team who have lived experience in jail; all other consenting implementation team members will be surveyed once early in the implementation process. Successfully completing the aims will determine factors that promote WBS implementation to improve disease monitoring in jails. By including persons recently released from jail on the implementation teams, we hope to inform researchers and policy makers about the ethics and process of collaboration in implementation.