Understanding HIV/STD Risk and Enhancing PrEP Implementation Messaging in a Diverse Community-Based Sample of Gay, Bisexual, and Other Men Who Have Sex with Men in a Transformational Era

摘要 美国的艾滋病预防工作正处于一个变革时期。在第一次发现 为了提高每日口服PrEP的有效性，新的PrEP制剂不断涌现，包括长效可注射PrEP， 和方案，包括“事件驱动”（也称为2-1-1）PrEP。 抗逆转录病毒药物（ARV）对治疗艾滋病毒的影响，以及对艾滋病毒感染者 服用抗逆转录病毒药物并保持抑制病毒载量的人不能将艾滋病毒传染给他们的性伴侣。 在这种情况下，“受保护”的性行为--历史上指的是用避孕套保护的性行为--已经成为 复杂得多。了解男性对预防产品和策略的偏好以及选择 是由具有不同风险特征的男性进行的，我们将招募1275名男性的前瞻性队列， 在亚特兰大，底特律和圣地亚哥的男男性接触者（MSM）中进行了为期两年的研究。每位参与者将 有8个季度的定量评估，包括谨慎的选择实验;一个子集的男男性接触者将 参与定性评估（焦点小组讨论和个人深入访谈），以帮助 信息开发和完善。艾滋病毒和性传播感染检测将在6个月的窗口期内交替进行。 快速报告结果将在每一波评估之后产生可采取行动的报告。该项目将 作为一个动态的数据来源，不断变化的模式使用和偏好的准备MSM之间。

Abstract The prevention of HIV in the United States is in a transformational era. In just a decade since the first finding of efficacy for daily oral PrEP, there is a proliferation of new PrEP agents, including long-acting injectable PrEP, and regimens, including “event-driven” (also called 2-1-1) PrEP. There has also been new knowledge about the impact of antiretrovirals (ARVs) for treatment of HIV, and an emergent understanding that people living with HIV who take ARVs and maintain a suppressed viral load are incapable of transmitting HIV to their sexual partners. In this context, the idea of “protected” sex – which historically meant sex protected by condoms – has become much more complex. To understand men’s preferences for prevention products and strategies and what choices are being made by men with varying risk profiles, we will enroll a prospective cohort of 1275 of men who have sex with men (MSM) in Atlanta, Detroit and San Diego and follow the cohort for two years. Each participant will have 8 quarterly quantitative assessments, including discreet choice experiments; a subset of MSM will be engaged in a qualitative assessments (focus group discussions and individual in-depth interviews) to help with message development and refinement. HIV and STI testing will be provided in alternating 6-month windows. Rapid reporting of results will produce actionable reports following each assessment wave. This project will serve as a dynamic source of data about the evolving patterns of use and preference for PrEP among MSM.