Understanding HIV/STD Risk and Enhancing PrEP Implementation Messaging in a Diverse Community-Based Sample of Gay, Bisexual, and Other Men Who Have Sex with Men in a Transformational Era

摘要 美国的艾滋病毒预防工作正处于一个转型时代。在短短十年内第一次发现了 对于每日口服PrEP的疗效，出现了新的PrEP药物的激增，包括长效注射PrEP， 以及治疗方案，包括“事件驱动”(也称为2-1-1)PrEP。也有了新的知识关于 抗逆转录病毒药物(ARV)治疗艾滋病毒的影响，以及对艾滋病毒携带者的紧急认识 服用抗逆转录病毒药物并保持被抑制的病毒载量的人无法将艾滋病毒传播给性伴侣。 在这种背景下，“受保护的”性行为--历史上指的是用避孕套保护的性行为--已经成为 要复杂得多。了解男性对预防产品和策略的偏好以及哪些选择 都是由具有不同风险特征的男性制造的，我们将招募1275名具有 在亚特兰大、底特律和圣地亚哥与男性发生性行为(MSM)，并跟踪队列两年。每个参与者都将 有8个季度的定量评估，包括谨慎的选择实验；MSM的子集将是 参与定性评估(焦点小组讨论和个人深入访谈)，以帮助 消息的开发和提炼。艾滋病毒和性传播感染检测将在6个月的窗口中交替提供。 快速报告结果将在每一次评估浪潮之后产生可操作的报告。这个项目将 作为有关MSM中PrEP使用和偏好的演变模式的动态数据来源。

Abstract The prevention of HIV in the United States is in a transformational era. In just a decade since the first finding of efficacy for daily oral PrEP, there is a proliferation of new PrEP agents, including long-acting injectable PrEP, and regimens, including “event-driven” (also called 2-1-1) PrEP. There has also been new knowledge about the impact of antiretrovirals (ARVs) for treatment of HIV, and an emergent understanding that people living with HIV who take ARVs and maintain a suppressed viral load are incapable of transmitting HIV to their sexual partners. In this context, the idea of “protected” sex – which historically meant sex protected by condoms – has become much more complex. To understand men’s preferences for prevention products and strategies and what choices are being made by men with varying risk profiles, we will enroll a prospective cohort of 1275 of men who have sex with men (MSM) in Atlanta, Detroit and San Diego and follow the cohort for two years. Each participant will have 8 quarterly quantitative assessments, including discreet choice experiments; a subset of MSM will be engaged in a qualitative assessments (focus group discussions and individual in-depth interviews) to help with message development and refinement. HIV and STI testing will be provided in alternating 6-month windows. Rapid reporting of results will produce actionable reports following each assessment wave. This project will serve as a dynamic source of data about the evolving patterns of use and preference for PrEP among MSM.