Mobile Messaging Intervention to Present New HIV Prevention Options for MSM

移动消息干预为 MSM 提供新的艾滋病毒预防方案

• 批准号: 9118794
• 负责人: Patrick Sean Sullivan
• 金额: $ 60万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9118794
• 关键词: Mobile; Messaging; Intervention; Present; New

 DESCRIPTION (provided by applicant): The prevention science is increasingly clear: biomedical interventions hold great promise to prolong life and decrease both infectiousness (of those living with HIV) and susceptibility (for those who are HIV-negative and take pre-exposure prophylaxis [PrEP]). However, these strategies do not stand alone; it is equally clear that combinations of behavior change and biomedical interventions work together to reduce new HIV infections for MSM. Biomedical tools will not have sufficient impact unless they are combined with increased HIV testing frequency, paired with coordinated behavior change interventions, integrated within communities, and brought to scale. We propose develop a new set of HIV prevention messages based on rigorous preliminary qualitative studies, and reflecting the current age of combination biomedical and behavioral prevention. We will use mobile technology to test the messages, and to provide links between targeted prevention services and service access points in Atlanta, Detroit, and New York. The prevention app through which the new messages will be tested has already been developed, building on a mixed-methods formative research process that incorporated the input of academics, community-based organizations, and health departments. The content of the new messages will be guided by Social Cognitive Theory. Once developed, the new messages will be tested in a delayed-onset design among 1206 MSM, stratified by HIV status (HIV-positive and HIV negative) and, within HIV-negative men, by risk (lower risk and high risk). Outcomes will be self-reported HIV prevention and risk outcomes, assessed at the end of a 3-month intervention period. The study team is well prepared to conduct the proposed activities, having enrolled >100,000 MSM in HIV prevention studies, having enrolled >20,000 MSM in 11 RCTs of HIV prevention research, and having develop multiple mobile applications for HIV prevention and research with MSM.

 描述(由申请人提供)：预防科学越来越清楚：生物医学干预措施在延长生命和降低(艾滋病毒携带者)传染性和易感性(针对艾滋病毒阴性并采取暴露前预防措施[PrEP])方面大有希望。然而，这些战略并不是孤立的；同样明显的是，行为改变和生物医学干预相结合，共同努力减少男男性行为者新的艾滋病毒感染。生物医学工具将不会产生足够的影响，除非它们与更高的艾滋病毒检测频率相结合，与协调一致的行为改变干预措施相结合，整合到社区中，并扩大规模。我们建议在严格的初步定性研究的基础上制定一套新的艾滋病毒预防信息，并反映当前生物医学和行为预防相结合的时代。我们将使用移动技术测试这些消息，并在亚特兰大、底特律和纽约的有针对性的预防服务和服务接入点之间提供链接。通过测试新消息的预防应用程序已经开发完成，建立在混合方法形成研究过程的基础上，该过程纳入了学者、社区组织和卫生部门的投入。新信息的内容将以社会认知理论为指导。一旦开发出新的信息，将在1206名男男性接触者中以延迟发作的设计进行测试，按艾滋病毒状况(艾滋病毒阳性和艾滋病毒阴性)分层，在艾滋病毒阴性的男性中，按风险(低风险和高风险)分层。结果将是自我报告的艾滋病毒预防和风险结果，在3个月的干预期结束时进行评估。研究小组已经为开展拟议的活动做好了充分的准备，已经招募了100,000名男男性接触者参加艾滋病毒预防研究，已经招募了20,000名男男性接触者参加了11项艾滋病毒预防研究随机对照试验，并已经开发了多种移动应用程序，用于艾滋病毒预防和与男男性接触者的研究。