T cell assay for BK virus infection in transplant patients

移植患者 BK 病毒感染的 T 细胞检测

• 批准号: 101601
• 金额: $ 21.3万
• 依托单位: OXFORD IMMUNOTEC
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=101601
• 关键词: cell; assay; BK; virus; infection

BK virus is endemic in the UK adult population. Although it causes little or no disease in healthy people the virus is known to persist in the kidney in particular. Reactivation of the virus is linked with immune suppressive conditions and this reactivation occurs in around 20% of kidney transplant patients and can lead to significant damage to the transplanted organ. While the level of the virus itself can be measured there is currently no test available that indicates whether or not the patient is able to fight off the infection successfully through their T cell response. This project is therefore aimed at proving the principle for the design of such a test so that kidney transplant recipients can be managed for the infection more effectively, leading to less transplanted organ loss due to this infection.

BK病毒在英国成年人群中流行。虽然它在健康人身上几乎不引起疾病，但已知该病毒特别在肾脏中持续存在。病毒的再活化与免疫抑制条件有关，这种再活化发生在约20%的肾移植患者中，并可能导致移植器官的严重损伤。虽然可以测量病毒本身的水平，但目前还没有可用的测试表明患者是否能够通过T细胞反应成功抵御感染。因此，该项目旨在证明这种测试的设计原则，以便更有效地管理肾移植受者的感染，从而减少由于这种感染而导致的移植器官损失。