Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin

任务领域 A 应包括队列成员的年度随访、临床事件调查、研究操作以及数据分析和稿件撰写。

• 批准号: 10551091
• 负责人: Gregory Burke
• 金额: $ 50.64万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-19 至 2022-12-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551091
• 关键词: Abdomen; Address; Ancillary Study; Ankle; Area; Behavioral; Cardiovascular Diseases; Characteristics; Clinical; Collaborations; Collection; Contracts; Coronary Arteriosclerosis; Data; Data Analyses; Disease; Event; Fostering; Functional disorder; Funding; Goals; Investigation; Laboratories; Magnetic Resonance Imaging; Manuscripts; Measurement; Measures; Multi-Ethnic Study of Atherosclerosis; Myocardial; National Heart, Lung, and Blood Institute; Participant; Photography; Policies; Population Heterogeneity; Process; Research Personnel; Retina; Risk Factors; Risk Marker; Sampling; Subgroup; United States National Institutes of Health; Woman; Writing; X-Ray Computed Tomography; aged; brachial artery; cardiac magnetic resonance imaging; clinical examination; cohort; follow-up; genetic variant; indexing; interest; member; men; operation; population based; predict clinical outcome; psychologic; radial artery; recruit; response; socioeconomics; tonometry; ultrasound

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flowmediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.

动脉粥样硬化的多种族研究（梅萨）是一项研究相关因素，预测因素和进展 亚临床心血管疾病（CVD）在不同人群中的分布 年龄45-84岁，基线时无临床CVD证据。在梅萨的初始供资期间， 在2000-2002年期间，从六个外地中心招募了6 814名参与者，并对他们进行了检查，以确定是否存在以下证据： 亚临床冠状动脉粥样硬化，使用计算机断层扫描，心脏MRI，颈动脉超声，血流介导 肱动脉扩张、桡动脉张力测定、踝肱指数测量和视网膜 摄影.一些其他变量包括腹主动脉CT、颈动脉MRI、心脏MRI 标记局部心肌功能的测量;已建立和推定的实验室风险标志物; 社会经济、心理、行为和环境特征;以及遗传变异， 在梅萨队列的子集中进行评估。对选定的部件重复检查5次以上 随后的检查跨越约16年，该队列一直在不断 随访自基线检查以来的临床CVD事件。 该研究将继续支持在NHLBI合同之外资助的深入辅助研究。 这些研究将在操作上整合到主要研究中，数据将在整个 整个“梅萨套件”的研究，根据目前的梅萨和NIH数据共享政策。研究数据将 通过鼓励最大限度利用数据的规定流程提供给感兴趣的研究者 同时保护参与者的机密性。