Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin

动脉粥样硬化的多种族研究(MESA)是一项关于相关因素、预测因素和进展的研究 亚临床心血管疾病(CVD)在男女不同人群样本中的分布 年龄45-84岁，基线时没有临床心血管疾病的证据。在MESA的最初供资期间， 在2000-2002年间，从6个外地中心招募了6814名参与者，并对其进行了检查，以寻找 亚临床冠状动脉粥样硬化，使用计算机断层扫描，心脏核磁共振，颈动脉超声，流动介导法 臂动脉扩张、放射状动脉眼压测量、踝臂指数测量和视网膜 摄影。其他一些变量包括腹主动脉CT、颈动脉MRI、心脏MRI 局部心肌功能测量的标记；已确定的和假定的实验室风险标记； 社会经济、心理、行为和环境特征；以及遗传变异 在台地队列的子集中进行评估。对选定的成分进行了五次以上的重复检查 随后的检查跨越了大约16年，队列一直在不断地 随访自基线检查以来发生的临床心血管事件。 这项研究将继续支持在NHLBI合同之外资助的深入辅助研究。 这些研究将在业务上整合到主要研究中，数据将在 根据当前MESA和NIH的数据共享政策，研究的整个“MESA套件”。该研究的数据将是 通过明确的流程提供给感兴趣的调查人员，以鼓励最大限度地提高数据利用率 同时保护参与者机密性。

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flowmediated brachial artery dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA cohort. Examinations of selected components were repeated over five subsequent examinations spanning approximately 16 years and the cohort has been continuously followed for clinical CVD events since the baseline examination. The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract. These studies will be operationally integrated into the main study, and the data will be shared across the entire “MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to interested investigators through a defined process that encourages maximum data utilization while protecting participant confidentiality.