Nonhuman Primate Core Virology Laboratory for AIDS Vaccine Research and Development

非人灵长类艾滋病疫苗研发核心病毒学实验室

• 批准号: 10551146
• 负责人: THOMAS DENNY
• 金额: $ 78.45万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-12-22 至 2022-12-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551146
• 关键词: AIDS Vaccines; Acquired Immunodeficiency Syndrome; Biological Assay; Contractor; Contracts; Ensure; HIV vaccine; HIV/SIV vaccine; Immunize; Immunologics; Immunology; Laboratories; Measurement; Measures; National Institute of Allergy and Infectious Disease; Research Personnel; SIV; SIV Vaccines; Simian Acquired Immunodeficiency Syndrome; Site; Standardization; Technology; United States National Institutes of Health; assay development; design; immunogenicity; improved; nonhuman primate; pre-clinical; preclinical study; prototype; research and development; simian human immunodeficiency virus; vaccine efficacy; vaccine evaluation; viral RNA; virology

The NIAID Division of AIDS has a requirement for the conduct of quantitative viral RNA measurements for assessment of HIV/SIV vaccine efficacy in preclinical studies with nonhuman primates. The NIAID provides immunological and virological support for nonhuman primate studies conducted at NIAID’s Simian Vaccine Evaluation Unit contract sites (SVEUs) and by AIDS vaccine researchers through three Nonhuman Primate Immunology and Virology Laboratories for AIDS Vaccine Research and Development, previously called the NHP “Core Laboratories.” The objective of the Core Laboratories has been to ensure standardization and comparability of the assays conducted for preclinical NHP studies and to provide a common basis for assessment of the immunogenicity and efficacy of candidate HIV and SIV vaccines.

NIAID AIDS分部要求进行定量病毒RNA测量，以评估非人灵长类动物临床前研究中HIV/SIV疫苗的有效性。NIAID为在NIAID的猿猴疫苗评估单位合同地点（SVEU）进行的非人灵长类动物研究提供免疫学和病毒学支持，并由艾滋病疫苗研究人员通过三个非人灵长类动物免疫学和病毒学实验室进行艾滋病疫苗研究和开发，以前称为NHP“核心实验室”。 核心实验室的目标是确保临床前NHP研究所进行的试验的标准化和可比性，并为评估候选HIV和SIV疫苗的免疫原性和有效性提供共同基础。