Nonhuman Primate Core Virology Laboratory for AIDS Vaccine Research and Development

NIAID艾滋病部门要求在非人类灵长类动物的临床前研究中进行定量病毒RNA测量，以评估HIV/SIV疫苗的有效性。NIAID为在NIAID的猿猴疫苗评估单位合同地点(SVEU)进行的非人灵长类研究提供免疫学和病毒学支持，并由艾滋病疫苗研究人员通过三个用于艾滋病疫苗研究和开发的非人灵长类免疫学和病毒学实验室提供免疫和病毒学支持，这三个实验室以前被称为NHP“核心实验室”。核心实验室的目标是确保为临床前NHP研究进行的分析的标准化和可比性，并为评估候选艾滋病毒和SIV疫苗的免疫原性和有效性提供共同基础。

The NIAID Division of AIDS has a requirement for the conduct of quantitative viral RNA measurements for assessment of HIV/SIV vaccine efficacy in preclinical studies with nonhuman primates. The NIAID provides immunological and virological support for nonhuman primate studies conducted at NIAID’s Simian Vaccine Evaluation Unit contract sites (SVEUs) and by AIDS vaccine researchers through three Nonhuman Primate Immunology and Virology Laboratories for AIDS Vaccine Research and Development, previously called the NHP “Core Laboratories.” The objective of the Core Laboratories has been to ensure standardization and comparability of the assays conducted for preclinical NHP studies and to provide a common basis for assessment of the immunogenicity and efficacy of candidate HIV and SIV vaccines.