High Throughput Toxicological Screening Support

该项目的目标是提供基于化学的服务，以支持国家毒理学计划(NTP)的危险识别活动，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。在毒性研究中，必须进行适当的化学分析，以确保试验物种暴露在指定剂量浓度的指定化学品中。这份合同有助于毒性研究提供癌症风险增加的证据以及其他毒理学结果，方法是提供研究的化学特征，包括所研究化学物质的明确身份和纯度，确认给药配方中的剂量浓度，以及测试物种中多个生物基质或目标器官的内部剂量测定。关于研究化学品的身份和纯度以及研究化学品在剂量配方中的浓度的信息，对于正确评估毒性试验和就研究化学品在试验物种中的潜在毒性得出合理、科学的结论至关重要。已确认的身份和纯度、剂量浓度以及通过本合同工作获得的与内部剂量相关的信息，最终支持国家毒理学计划和其他联邦机构的风险评估工作。这份合同提供的内部剂量信息还可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的危险因素。

The goal of this project is to provide chemistry-based services to support National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing study chemical characterization, including unequivocal identity and purity of the chemicals studied, confirmation of the dose concentrations in administered formulations, and internal dose determinations in multiple biological matrices or target organs in the test species. Information about the identity and purity of study chemicals and the concentration of study chemicals in dose formulations is critical to proper evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species. Confirmed identity and purity, dose concentrations and the information obtained through the work of this contract relating to internal dose, ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. Internal dose information provided by this contract also enables extrapolations to humans to be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.