High Throughput Toxicological Screening Support

高通量毒理学筛查支持

• 批准号: 10551028
• 负责人: Kristin Aillon
• 金额: $ 59.32万
• 依托单位: MIDWEST RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-18 至 2022-03-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10551028
• 关键词: Adverse effects; Agrochemicals; Analytical Chemistry; Biological; Biological Assay; Chemicals; Chemistry; Contracts; Development; Dose; Economics; Ensure; Environmental Exposure; Equipment and supply inventories; Evaluation; Evaluation Studies; Exposure to; Formulation; Gases; Goals; Hazard Identification; Hazardous Chemicals; Health; Heightened Cancer Risk; High Pressure Liquid Chromatography; Human; In Vitro; Individual; Maintenance; Mass Fragmentography; Methods; NMR Spectroscopy; National Institute of Environmental Health Sciences; National Toxicology Program; Organ; Outcome; Preparation; Process; Protocols documentation; Reporting; Research; Risk Assessment; Risk Factors; Services; Ships; Solubility; Source; Specific qualifier value; Testing; Toxic effect; Toxicity Tests; Toxicology; Translational Research; Validation; Work; Zebrafish; base; disorder prevention; dose information; high throughput screening; liquid chromatography mass spectrometry; programs; public health research; research facility; screening; small molecule libraries; sound; zebrafish development

The goal of this project is to provide chemistry-based services to support National Toxicology Program (NTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper chemical analyses are required to ensure that, in toxicity studies, the test species are exposed to the prescribed chemicals at the specified dose concentrations. This contract contributes to the ability of toxicity studies to provide evidence of heightened cancer risk along with other toxicological outcomes, by providing study chemical characterization, including unequivocal identity and purity of the chemicals studied, confirmation of the dose concentrations in administered formulations, and internal dose determinations in multiple biological matrices or target organs in the test species. Information about the identity and purity of study chemicals and the concentration of study chemicals in dose formulations is critical to proper evaluation of toxicity tests and development of sound, scientific conclusions about the potential toxicity of the study chemical in the test species. Confirmed identity and purity, dose concentrations and the information obtained through the work of this contract relating to internal dose, ultimately supports the risk assessment efforts of National Toxicology Program and other federal agencies. Internal dose information provided by this contract also enables extrapolations to humans to be made so that the public can be adequately informed about risk factors arising from exposure to studied chemicals.

该项目的目标是提供基于化学的服务，以支持国家毒理学计划（NTP）的危害识别活动，旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的化学分析，以确保在毒性研究中，试验种属以规定的剂量浓度暴露于规定的化学品。该合同通过提供研究化学表征，包括所研究化学品的明确鉴别和纯度，确认给药制剂中的剂量浓度，以及试验种属中多种生物基质或靶器官的内部剂量测定，有助于毒性研究提供癌症风险升高沿着其他毒理学结果的证据。关于研究化学品的鉴别和纯度以及给药制剂中研究化学品浓度的信息对于正确评价毒性试验和得出关于研究化学品在试验种属中的潜在毒性的合理科学结论至关重要。确认的同一性和纯度、剂量浓度以及通过本合同工作获得的与内部剂量相关的信息最终支持国家毒理学计划和其他联邦机构的风险评估工作。该合同提供的内部剂量信息还可以对人类进行推断，以便公众能够充分了解接触所研究的化学品所产生的风险因素。