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Accelerated Synthesis of Agrochemicals and Pharmaceuticals (ASAP): Bridging the Gap Between Research and Application

农用化学品和药物的加速合成 (ASAP)：弥合研究与应用之间的差距

基本信息

批准号：
MR/V022067/1
负责人：
Liam Thomas Ball
金额：
$ 177.22万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=MR%2FV022067%2F1
关键词：
Accelerated Synthesis Agrochemicals Pharmaceuticals ASAP

项目摘要

Food and healthcare are the foundations on which our current quality of life is built. The pressure on these resources will only increase as the UK population ages, the global population reaches 9 billion in 2050 and the worst effects of climate change begin to manifest. Now more than ever, new medicines and agrochemicals will be vital in combating the growing and evolving threats that face society. A major challenge to the development of new medicines and agrochemicals is the high attrition rate of the candidate molecules being investigated, which drives up the financial cost, environmental impact and time associated with bringing a new product to market. Methods that allow rapid cost- and resource efficient preparation of desirable candidate molecules are therefore extremely valuable. This programme will deliver a suite of synthesis methods to streamline the discovery and development of the next generation of agrochemicals and pharmaceuticals. Building on our recent discovery, we will develop new ways of making valuable molecular architectures while minimising the number of chemical operations required and avoiding the use of toxic or precious elements. By working in close collaboration with leading innovators in crop protection (Syngenta) and human healthcare (AstraZeneca, Pfizer and Carbometrics), we will ensure that our methods will be of direct and immediate benefit. We will also seek to make the reagents we develop commercially available, thus further enabling the rapid and barrierless uptake of our methods.

食品和医疗保健是我们目前生活质量的基础。随着英国人口老龄化，全球人口在2050年达到90亿，气候变化的最严重影响开始显现，这些资源的压力只会增加。现在，新药和农用化学品在应对社会面临的日益增长和不断变化的威胁方面比以往任何时候都更加重要。新药和农用化学品开发的一个主要挑战是正在研究的候选分子的高损耗率，这增加了与将新产品推向市场相关的财务成本、环境影响和时间。因此，允许快速成本和资源有效地制备所需候选分子的方法是极其有价值的。该计划将提供一套合成方法，以简化下一代农用化学品和药物的发现和开发。在我们最近发现的基础上，我们将开发新的方法来制造有价值的分子结构，同时最大限度地减少所需的化学操作数量，避免使用有毒或贵重元素。通过与作物保护（先正达）和人类医疗保健（阿斯利康，辉瑞和Carbometrics）领域的领先创新者密切合作，我们将确保我们的方法将直接和立即受益。我们还将寻求使我们开发的试剂商业化，从而进一步实现我们的方法的快速和无障碍吸收。