Administrative Core

行政核心

• 批准号: 10551704
• 负责人: Michael R Yeaman
• 金额: $ 16.15万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-10 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10551704
• 关键词: Academic Medical Centers; Accounting; Achievement; Administrator; Area; Benchmarking; Bioinformatics; Budgets; Collaborations; Communicable Diseases; Communication; Communities; Computer Models; Computer software; Consultations; Dedications; Development; Discipline; Education; Educational workshop; Ensure; Environment; Epigenetic Process; Equity; Evaluation; FAIR principles; Faculty; Funding; Goals; Grant; Human Resources; Infrastructure; International; Intranet; Investigation; Journals; Learning; Life; Manuscripts; Medical; Medical center; Mining; Modeling; Molecular Medicine; Monitor; National Institute of Allergy and Infectious Disease; Network Infrastructure; Outcome; Performance; Policies; Postdoctoral Fellow; Process; Publishing; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Sepsis; Services; Students; System; Systems Biology; Technology; Teleconferences; Time; Translational Research; United States National Institutes of Health; career; career development; clinical application; cost effective; data dissemination; data management; data sharing; design; digital; epigenomics; equity, diversity, and inclusion; improved; innovation; meetings; multidisciplinary; novel; outreach; pathogen; peer networks; predictive modeling; programs; prospective; skills; success; symposium; synergism; timeline; translational applications; translational potential

PROJECT SUMMARY/ABSTRACT The current Center proposal, entitled “Systems Epigenomics of Persistent Bloodstream Infection” represents a synergistic approach to understanding the host-pathogen interactions that result in life-threatening bloodstream infections that do not clear on appropriate therapy. A highly innovative and expert team has been assembled to implement a systems-biology strategy that is ideally aligned to achieve NIH / NIAID priorities. A diverse set of expertise, technologies and activities are necessary to efficiently reach our objectives. To effectively manage this integrated research program, we will implement our proven Administrative Network Core (ANC) to interact with each Project and Core. Thus, synergistic collaboration, research efficiency and discovery will be enhanced. The ANC design will afford highly efficient coordination among investigators and Center components, including Projects 1–3, and our Immunomics & Epigenetics (IEC), Bionformatics & Data Management (BDM) and Computational & Predictive Modeling (CPM) Cores. Coordination with Collaborators and Consultants by the ANC further amplifies the programmatic strengths of the Center. The ANC will provide a supportive infrastructure to ensure accomplishment of all Center goals: 1) managing the project financial and personnel resources; 2) facilitating coordination and integration of research Projects, Cores and Advisors; 3) ensuring quality improvement by monitoring of benchmark metrics and logistical optimization; 4) overseeing the solicitation, review, selection and monitoring of Supplemental Research Projects; and 5) promote a positive research environment that is equitable, inclusive and diverse. Thus, the ANC will support the overall Center to inform, coordinate, monitor and advance timely completion of all research goals.

项目总结/摘要 该中心目前的提案，题为“持续性血流感染的系统表观基因组学”， 理解导致危及生命血流的宿主-病原体相互作用的协同方法 感染没有清除适当的治疗。一个高度创新的专家团队已经组建， 实施系统生物学战略，以实现NIH / NIAID的优先事项。多样化的专业知识， 技术和活动是有效实现我们目标所必需的。为了有效地管理这一综合 研究计划，我们将实施我们成熟的管理网络核心（ANC）与每个项目进行互动， 核心因此，协同合作，研究效率和发现将得到加强。ANC设计将提供 研究人员和中心组成部分之间的高效协调，包括项目1-3和我们的免疫组学 和表观遗传学（IEC），生物信息学和数据管理（BDM）和计算和预测建模（CPM）核心。 非洲人国民大会与合作者和顾问的协调进一步增强了该中心的方案优势。的 ANC将提供支持性基础设施，以确保实现中心的所有目标：1）管理项目 财政和人力资源; 2）促进研究项目、核心和顾问的协调和整合; 3)通过监测基准指标和后勤优化确保质量改进; 4）监督 征集、审查、选择和监督补充研究项目; 5）促进积极的研究 一个公平、包容和多样化的环境。因此，非洲人国民大会将支持整个中心提供信息，协调， 监督并及时完成所有研究目标。