Developing wearable OPM-MEG to assess brain function in mother-infant dyads during social interactions

项目总结 拟议的工作将使目前可穿戴的光泵磁力计 用于婴儿的脑磁图(OpmMEG)，然后将进一步修改这些方案以用于 在自然社会互动中同时记录母婴二人组的大脑活动。虽然两者都 脑电(EEG)和功能磁共振成像(FMRI)已被用于评估 婴儿的大脑功能，EEG甚至被用来同时评估母婴的二元大脑 功能在自然主义的互动中，它们各自都有可穿戴的opmMEG解决的局限性。 EEG和fMRI都允许高时间、毫秒级的分辨率；然而，EEG对来源提出了挑战 本地化。尽管功能磁共振成像解决了EEG的来源定位问题，但它不能实现相同的目标 自然主义的社会范式，如脑电，也是喧闹和昂贵的。OpmMEG是非侵入性、安静和 提供高时间分辨率和精确的震源定位。OPM可在房间内使用 与其他MEG传感器不同的是，必须使用昂贵的冷冻剂来冷却。OPM也很小 而且重量轻，这使得它们适合用于可穿戴头盔，即使在范例中也可以使用 这包括参与者动议。OpmMEG的所有这些特点使其成为一种理想的适应对象 用于婴儿，并进一步用于自然相互作用的母婴二联体。评估大脑功能的能力 同时在母婴二元体内代表着一个前所未有的机会来获得关于 典型发育，这是能够识别临床相关的脑功能指示模式的关键 后来出现的精神病理学。一旦拟议的工作完成，我们将开发出 优化的方案，以及有史以来第一次在婴儿中收集的opmMEG数据，以及第一次 同时收集的母婴opmMEG是在自然主义的、身体接触的、社交的 互动。这一提议所代表的创新对于推动婴儿成像领域至关重要 在垂直方向上使用存在于 发育独特且具有形成性的母婴二分体。

PROJECT SUMMARY The proposed work will adapt current wearable, optically pumped magnetometer-based magnetoencephalography (opmMEG) for use in infants, and will then further adapt these protocols for simultaneous recording of brain activity in mother-infant dyads during naturalistic social interactions. While both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) have been used to assess brain function in infants, and EEG has even been used to simultaneously assess mother-infant dyad brain function during naturalistic interactions, they each have limitations that are addressed by wearable opmMEG. Both EEG and fMRI allow for high temporal, millisecond, resolution; however, EEG poses challenges for source localization. Although fMRI addresses the source localization issues of EEG, it does not allow for the same naturalistic social paradigms as EEG, and is also loud and expensive. OpmMEG is non-invasive, quiet, and provides both high temporal resolution and accurate source localization. OPMs can be used at room temperature, unlike other MEG sensors that must be cooled using expensive cryogens. OPMs are also small and lightweight, making them amenable to use in wearable helmets, which can be used even during paradigms that include participant motion. All of these characteristics of opmMEG make it an ideal candidate for adaptation for use in infants, and further, use in naturally interacting mother-infant dyads. The ability to assess brain function simultaneously within a mother-infant dyad represents an unprecedented opportunity to gain knowledge about typical development, which is key to being able to recognize clinically relevant patterns of brain function indicative of later emerging psychopathology. Once the proposed work is completed, we will have developed optimized protocols, and the first-ever opmMEG data collected in an infant, as well as the first ever simultaneous mother-infant opmMEG collected during naturalistic, physically-touching, social interactions. The innovations represented by this proposal are paramount to moving the field of infant imaging vertically to improve our understanding of neurodevelopment using salient social interactions that exist within the developmentally unique and formative mother-infant dyad.