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Thalamocortical interactions

丘脑皮质相互作用

基本信息

批准号：
10552050
负责人：
Jason Neil MacLean
金额：
$ 58.48万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10552050
关键词：
Abbreviations Acetylcholine Address Affect Alzheimer&apos s Disease Anatomy Area Back Behavioral Binding Biological Models Brain Cell Nucleus Cells Cognitive deficits Control Animal Data Dependovirus Detection Discrimination Dorsal Electrodes Electrophysiology (science)Excitatory Postsynaptic Potentials Explosion Feedback Fluorescence Future Generations Geniculate body structure Glutamates Image In Vitro Label Lateral Geniculate Body Maps Medial Metabotropic Glutamate Receptors Modeling Monitor Motor Cortex Mus Nerve Neurons Pathway Analysis Pathway interactions Pattern Peripheral Phase Physiology Play Preparation Progress Reports Property Pulvinar structure Research Role Route Schizophrenia Sensory Short-Term Memory Slice Source Spinal Stimulus Synapses Synaptic Potentials System Tactile Techniques Testing Thalamic Nuclei Thalamic structure Vertebral column barrel cortex behavior test cognitive function density experimental study gamma-Aminobutyric Acid in vivo interest neglect postsynaptic programs redshift response sensory cortex sensory input somatosensory transmission process two-photon

项目摘要

The proposed research will test related hypotheses that thalamus plays a heretofore neglected and critical role in cortical processing. In particular, many thalamic nuclei, that together comprise the majority of thalamic volume and that were previously mysterious in function, we now suggest are critically involved in information flow and functional, dynamic binding between cortical areas via cortico-thalamo-cortical pathways. We propose to study these pathways using the mouse somatosensory system as the model involving both in vitro slice preparations and an in vivo behaving preparation. It appears that, in many and perhaps all cases, cortical areas are connected by both direct and these transthalamic pathways. The transthalamic pathways are only recently appreciated, and we aim to explore some basic roles such pathways play in cortical processing. To begin understanding the role of such pathways, we propose to probe basic circuit properties of these pathways to better understand the role of the transthalamic pathways in higher cognitive functioning.

这项拟议的研究将检验相关假设，即丘脑扮演着迄今被忽视的和在大脑皮层处理中的关键作用。特别是，许多丘脑核团共同组成了丘脑的大部分体积和以前神秘的功能，我们现在建议是关键地参与信息流和皮质区域之间的功能性动态绑定皮质-丘脑-皮质通路。我们建议用小鼠来研究这些途径体感系统作为包括体外切片制备和体内注射的模型做好准备。似乎在许多情况下，也许所有情况下，大脑皮层区域是相连的。通过直接通路和这些跨丘脑通路。跨丘脑通路是最近才出现的。我们的目标是探索这类通路在皮层处理中所起的一些基本作用。至开始了解这些通路的作用，我们建议探索基本的电路属性这些通路有助于更好地理解跨丘脑通路在高等认知中的作用功能正常。