Thalamocortical interactions

丘脑皮质相互作用

• 批准号: 10824613
• 负责人: Jason Neil MacLean
• 金额: $ 3.62万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10824613
• 关键词: Action Potentials; Affect; Alzheimer' s Disease; Area; Behavior; Behavioral; Binding; Calcium; Cells; Cognitive deficits; Control Animal; Data; Detection; Discrimination; Electrodes; Electrophysiology (science); Fluorescence; Goals; Image; In Vitro; Investigation; Measures; Modeling; Monitor; Mus; Neurons; Pathway Analysis; Pathway interactions; Pattern; Phase; Play; Preparation; Progress Reports; Property; Research; Role; Schizophrenia; Secondary to; Sensory; Short-Term Memory; Slice; Somatosensory Cortex; Sorting; Stimulus; System; Tactile; Testing; Thalamic Nuclei; Thalamic structure; behavior test; cognitive function; evidence base; follow-up; in vivo; insight; neglect; redshift; response; somatosensory; transmission process; two-photon

The proposed research will test related hypotheses that thalamus plays a heretofore neglected and critical role in cortical processing. In particular, many thalamic nuclei, that together comprise the majority of thalamic volume and that were previously mysterious in function, we now suggest are critically involved in information flow and functional, dynamic binding between cortical areas via cortico-thalamo-cortical pathways. We propose to study these pathways using the mouse somatosensory system as the model involving both in vitro slice preparations and an in vivo behaving preparation. It appears that, in many and perhaps all cases, cortical areas are connected by both direct and these transthalamic pathways. The transthalamic pathways are only recently appreciated, and we aim to explore some basic roles such pathways play in cortical processing. To begin understanding the role of such pathways, we propose to probe basic circuit properties of these pathways to better understand the role of the transthalamic pathways in higher cognitive functioning.

The proposed research will test related hypotheses that thalamus plays a heretofore neglected and critical role in cortical processing. In particular, many thalamic nuclei, that together comprise the majority of thalamic volume and that were previously mysterious in function, we now suggest are critically involved in information flow and functional, dynamic binding between cortical areas via cortico-thalamo-cortical pathways. We propose to study these pathways using the mouse somatosensory system as the model involving both in vitro slice preparations and an in vivo behaving preparation. It appears that, in many and perhaps all cases, cortical areas are connected 通过直接和这些经过脑丘脑的途径。脑丘脑途径直到最近才 值得赞赏的是，我们旨在探索这种途径在皮质加工中发挥的基本作用。到 开始理解这种途径的作用，我们建议探测的基本电路特性 这些途径更好地了解脑丘脑途径在较高认知中的作用 功能。