Defining maternal and neonatal antibody responses in congenital Zika virus infection

定义先天性寨卡病毒感染中的孕产妇和新生儿抗体反应

• 批准号: 10552684
• 负责人: Emma L Mohr
• 金额: $ 19.8万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-12 至 2024-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10552684
• 关键词: Acceleration; Affect; Affinity; Animals; Antibodies; Antibody Response; Area; Award; Binding; Bioinformatics; Biological Sciences; Central America; Child Health; Clinical Investigator Award; Clinical Trials; Collaborations; Complement; Congenital Abnormality; Data; Development; Development Plans; Drug or chemical Tissue Distribution; Education; Environment; Enzyme-Linked Immunosorbent Assay; Epitopes; Faculty; Fetal Development; Fetal Tissues; Fetus; Funding; Future; Goals; Human; Immune; Immune response; Immunology; Immunotherapy; Incidence; Individual; Infant; Infant Development; Infection; Infection prevention; Institution; Investigation; Laboratories; Leadership; Link; Maternal antibody; Measurable; Measures; Mentors; Modeling; Molecular Virology; Monoclonal Antibodies; Morbidity - disease rate; Neonatal; Neutralization Tests; Outcome; Patients; Peptides; Persons; Phenotype; Play; Polyproteins; Pregnancy; Pregnant Women; Primates; Prophylactic treatment; Publishing; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; South America; Time; Training; Training Activity; Travel; United States; United States National Institutes of Health; Universities; Vertical Transmission; Viral; Viremia; Virion; Virus; Virus Diseases; Wisconsin; Work; ZIKV infection; Zika Virus; Zika virus vaccine; animal facility; brain abnormalities; career; career development; congenital infection; design; experimental study; fetal; hearing impairment; hearing range; human disease; human model; improved; innovation; maternal serum; member; mortality; neutralizing antibody; neutralizing monoclonal antibodies; nonhuman primate; pediatric department; pregnant; programs; prophylactic; skills; transmission process; unvaccinated

Abstract Candidate. My career goal is to improve the health of children with congenital viral infections by defin- ing the relationship between the fetomaternal immune response and outcomes of congenital infection. My short-term objective is to refine and add to my skills as an independent investigator and begin my independent research career as a junior faculty member at the University of Wisconsin on an acceler- ated trajectory with the protected time and resources to develop my research program. The education linked to this proposal is in the areas of fetomaternal immunology, bioinformatics and fetal development, which will enable me to complement my prior training in molecular virology and develop an innovative approach to the study of the immune response to congenital Zika virus infection. Research Project. Infection with Zika virus (ZIKV) during pregnancy is associated with congenital in- fection and the development of birth defects. Maternal infection results in transmission to the fetus and the virus disseminates throughout fetal tissues resulting in birth defects. Some infants have severe birth defects and others are either not affected or only mildly affected. Determining the relationship between the fetomaternal immune response and these different infection phenotypes is critical for defining the fetomaternal immune response that results in limited fetal harm. Characterization of this immune re- sponse will provide targets for immunotherapy development, which is necessary to reduce the mortality and morbidity from congenital ZIKV infection. Career Development Plan. My proposed mentoring and training activities will focus on (1) attaining expertise in fetomaternal immunology, bioinformatics and fetal/infant development through mentoring, hands-on laboratory work and coursework; (2) developing leadership skills to pursue investigations in an independent laboratory; (3) presenting and publishing data; and (4) continuing and expanding pro- fessional collaborations. My research will be closely coordinated with my training activities and will build toward a successful R01 application in the fourth year of this award. Research Environment. I am well supported within the Department of Pediatrics at the University of Wisconsin with independent laboratory space. I will continue to benefit from the outstanding collabora- tive biological sciences research infrastructure at our institution and nonhuman primate animal facilities at the Wisconsin National Primate Research Center.

摘要