The OHSU SIREN Network Enrollment Hub Renewal

OHSU SIREN 网络招生中心更新

• 批准号: 10552340
• 负责人: MOHAMUD RAMZANALI DAYA
• 金额: $ 38.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10552340
• 关键词: Accident and Emergency department; Active Learning; Acute Lung Injury; Anesthesia procedures; Award; Cardiac; Cardiology; Cardiovascular system; Clinical; Clinical Trials; Clinical Trials Network; Collaborations; Communicable Diseases; Communication; Contracts; Coronary; Critical Care; Data; Early treatment; Electric Countershock; Eligibility Determination; Emergency Care; Emergency Medicine; Emergency Situation; Emergency medical service; Emergency research; Enrollment; Ensure; Event; Faculty; Funding; Geography; Goals; Grant; Health; Health Services Research; Hematology; Hospitals; Informed Consent; Institution; Institutional Review Boards; Investigation; Lead; Leadership; Learning; Link; Lung; Mentors; Methodology; Methods; Minority; Multi-Institutional Clinical Trial; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; Neurologic; Neurological emergencies; Neurology; Operative Surgical Procedures; Oregon; Outcome; Patient-Focused Outcomes; Patients; Physicians; Positioning Attribute; Prevention; Principal Investigator; Productivity; Research; Research Personnel; Research Training; Resuscitation; Science; Scientist; Service setting; Site; Structure; Training; Trauma; United States; United States Agency for Healthcare Research and Quality; United States Health Resources and Services Administration; United States National Institutes of Health; Universities; acute care; clinical trial analysis; design; experience; improved outcome; innovation; meetings; member; multidisciplinary; neurosurgery; next generation; operation; out-of-hospital cardiac arrest; participant enrollment; patient population; payment; pediatric emergency; recruit; respiratory; success; trauma care; treatment trial

Oregon Health & Science University (OHSU) has the institutional experience, study team leadership, pre-existing emergency department (ED), and emergency medical services (EMS) research network framework to lead a successful hub for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The OHSU Hub is the top performer amongst all SIREN hubs, enrolling 203 patients across 4 trials. Our hub includes a geographically dispersed footprint consisting of 8 institutions across six regions, resulting in a productive hub covering a diverse patient population. The OHSU Department of Emergency Medicine (DEM) has been ranked in the top ten for NIH EM funding annually for over a decade.1 Our faculty team members are all federally funded (NIH/ DoD/ CDC/ AHRQ/ HRSA) physician-scientists with >30 years of multisite ED/EMS research experience. We will leverage our extensive experience to 1. Continue the OHSU Hub's strong participation and enrollment in SIREN trials through an expansive network of investigators, research staff, clinical collaborators, and other partners. 1a. Continue existing effective collaborations. We will nurture the positive and productive relationships between our 7 spokes, 25 EMS agencies, and multidisciplinary subspecialty panels. 1b. Develop new collaborations and methods to increase enrollment. Expand the OHSU Hub by adding regional sites to increase the number of patients enrolled in clinical trials. 1c. Optimize communication to ensure the conduct of high-quality trials. Implement a bi-level communication approach: a. Study-specific meetings of study PIs/staff to share best practices; and b. Quarterly meetings with spoke PIs and staff for effective team building. 2. Actively contribute to governance and science of the national SIREN network 2a. Participate in SIREN governance efforts. Our team has served on SIREN committees, Operations, EMS, and Cardiovascular, and will continue our strong participation in SIREN committees. 2b. Lead SIREN scientific efforts. We propose one SIREN EMS trial, present multiple trial concepts. 3. Train the next generation of multidisciplinary physician-scientists in emergency care research (ECR), focusing on clinical trials methodology and experiential learning through SIREN. 3a. Recruit junior faculty of diverse backgrounds at 8 university sites to engage in a structured mentor- guided research training experience with a focus on clinical trials in emergency care. 3b. Optimize experiential learning, training, and collaboration, integrate all scholars into SIREN activities, to learn the design, implementation, conduct, and analysis of clinical trials in emergency care. The OHSU Hub will leverage its past success to promote the SIREN goals: large recruitment strategy, minority inclusiveness, pipeline expansion of clinical trialists, and meet the changing needs of ECR.

俄勒冈健康与科学大学(OHSU)拥有机构经验、研究团队领导力、现有的急诊科(ED)和紧急医疗服务(EMS)研究网络框架，能够成功地领导创新紧急护理临床试验网络(SIREN)的战略中心。OHSU中心是所有警报器中心中表现最好的，在4个试验中招募了203名患者。我们的中心包括一个地理上分散的足迹，由六个地区的8个机构组成，从而形成了一个覆盖不同患者群体的高效中心。OHSU急诊医学部(DEM)十多年来一直位居NIH EM资金前十名1我们的教员团队成员都是联邦资助(NIH/DoD/CDC/AHRQ/HRSA)的医生和科学家，拥有&GT；30年的多站点ED/EMS研究经验。我们将利用我们丰富的经验1.通过一个由研究人员、研究人员、临床合作者和其他合作伙伴组成的广泛网络，继续OHSU中心对SEREN试验的大力参与和招募。1A.继续现有的有效协作。我们将在我们的7个分支机构、25个EMS机构和多学科专业小组之间培养积极和富有成效的关系。1B.开发新的协作和方法以增加招生人数。通过增加地区性站点来扩大OHSU中心，以增加参加临床试验的患者数量。1C。优化沟通，确保高质量开展审判。实施两级沟通方法：a.研究绩效指标/工作人员的专题研究会议，以分享最佳实践；b.与发言的绩效指标和员工举行季度会议，以有效地进行团队建设。2.积极促进国家警报网2a的治理和科学化。参与警报器治理工作。我们的团队曾在SIREN委员会、运营委员会、EMS和心血管委员会任职，并将继续大力参与SIREN委员会的工作。2B。引领警报器的科学努力。我们提出了一次SIREN EMS试验，提出了多个试验概念。3.培养急救研究(ECR)的下一代多学科医生-科学家，重点是临床试验方法学和通过SIREN进行经验学习。3A.在8个大学地点招聘不同背景的初级教员，参与有组织的导师指导的研究培训体验，重点是紧急护理的临床试验。3B.优化体验式学习、培训和协作，将所有学者整合到SIREN活动中，学习急诊临床试验的设计、实施、实施和分析。OHSU中心将利用其过去的成功来促进SIREN目标：大规模招聘战略、少数族裔包容性、临床试验人员的流水线扩展，以及满足ECR不断变化的需求。