Family Matters: Optimizing Family-Based Interventions for Adolescents with Type 1 Diabetes

家庭事务：优化针对 1 型糖尿病青少年的家庭干预措施

• 批准号: 10553729
• 负责人: Jessie J. Wong
• 金额: $ 16.08万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553729
• 关键词: Adolescence; Adolescent; Adult; Age; Award; Behavior; Blinded; Caring; Child Rearing; Childhood diabetes; Clinic; Code; Conflict (Psychology); Control Groups; Data; Deterioration; Diabetes Mellitus; Disease Management; Distal; Enrollment; Ensure; Family; Family Process; Focus Groups; Foundations; Genetic Transcription; Glycosylated hemoglobin A; Goals; Health; Health Services; Individual; Insulin-Dependent Diabetes Mellitus; Intervention; Intervention Studies; Intervention Trial; Knowledge; Link; Literature; Mediating; Mediation; Mental Depression; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Modeling; Outcome; Parents; Participant; Pathway interactions; Process; Qualitative Methods; Quality of life; Randomized; Research; Resources; Risk; Sampling; Science; Scientist; Statistical Data Interpretation; Stress; Structure; Time; Training; Videoconferencing; Waiting Lists; Youth; acceptability and feasibility; base; behavioral health; biological development; career; comparison group; contextual factors; design; diabetes distress; diabetes management; experience; follow-up; glucose monitor; glycemic control; improved; improved outcome; integrated care; intersectionality; intervention effect; multi-component intervention; parental involvement; parental monitoring; patient outreach; patient screening; physical conditioning; prevent; primary endpoint; primary outcome; programs; psychosocial development; randomized trial; satisfaction; secondary outcome; skills; therapy design

Project Summary/Abstract Adolescents with type 1 diabetes (T1D) often experience deteriorations in glycemic control that can persist into adulthood. Although family-based interventions are empirically supported to offset this adolescent risk, such behavioral health services are rarely included in diabetes care. This K23 proposal seeks to bridge this gap between research and practice by optimizing family-based programs to provide the most efficacious, judicious, and streamlined intervention possible to adolescents with T1D. The proposed study aims to 1) pilot and evaluate specific family-based intervention components, and 2) identify the factors that explain and influence intervention effects. First, the candidate will use qualitative methods to pilot 3 intervention modules to assess feasibility and acceptability. Each module corresponds to one of 3 critical family processes: parental monitoring, parental involvement, and parent-adolescent conflict, each of which are empirically linked to adolescent diabetes management and glycemic control and are common family-based intervention targets. Next, the candidate will conduct an experimental trial of the intervention modules to evaluate their relative efficacy as well as combined impact on adolescent outcomes. Finally, the candidate will conduct advanced statistical analyses to verify the specific family processes (including both general and diabetes-specific) that explain (mediate) program effects as well as the contextual factors that influence (moderate) intervention effects. This proposal will yield an optimized family-based intervention as well as provide critical empirical information about the causal pathways between family functioning, mental health, and glycemic control among adolescents with T1D. The K23 award offers the training, mentorship, protected time, and resources necessary to complete the proposed study and support Dr. Wong’s progress toward becoming an independent research scientist in pediatric diabetes.

项目总结/摘要 青少年1型糖尿病（T1 D）患者通常会出现血糖控制恶化， 成年虽然以家庭为基础的干预措施在经验上支持抵消这种青少年风险， 行为健康服务很少包括在糖尿病护理中。K23提案旨在弥合这一差距 通过优化以家庭为基础的方案，以提供最有效，明智， 和简化的干预可能与T1 D青少年。拟议研究的目的是：1）试验和 评估具体的以家庭为基础的干预组成部分，2）确定解释和影响的因素 干预效果。首先，候选人将使用定性方法试点3个干预模块，以评估 可行性和可接受性。每个模块对应于3个关键的家庭过程之一： 监控，父母参与，和父母-青少年冲突，其中每一个都与经验有关， 青少年糖尿病管理和血糖控制是常见的家庭干预目标。 接下来，候选人将进行干预模块的实验性试验，以评估他们的相对 有效性以及对青少年结果的综合影响。最后，候选人将进行高级 统计分析，以验证特定的家庭过程（包括一般和糖尿病特异性）， 解释（中介）计划效果以及影响（适度）干预的背景因素 方面的影响.这一建议将产生一个优化的基于家庭的干预措施，并提供关键的经验， 关于家庭功能、心理健康和血糖控制之间因果关系的信息， 青少年T1 D K23奖提供必要的培训，指导，保护时间和资源 以完成拟议的研究，并支持黄博士的进展，成为一个独立的研究 儿科糖尿病专家