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Scientific Integration and Administration

科学整合与管理

基本信息

批准号：
10553989
负责人：
JANKO Z. NIKOLICH
金额：
$ 15.63万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2028-02-29
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10553989
关键词：
Address Animals Annual Reports Area Cell Aging Charge Collaborations Collection Communication Complex Data Data Analyses Discipline Documentation Ensure Environment Evaluation Evaluation Reports Fertilization Fostering Gerontology Goals Human Resources Immunology Individual Infrastructure Knowledge Knowledge Management Laboratories Metadata Monitor Mus Nerve Ontology Organism Peripheral Persons Phase Productivity Progress Reports Protocols documentation Qualifying Quality Control Reagent Rejuvenation Reproducibility Research Research Personnel Science Scientific Advances and Accomplishments Scientific Evaluation Scientist Secure Standardization Supervision System T-Lymphocyte Technology Text Thymus Gland Tissues Travel Videoconferencing Visit Work Writing adjudication analytical tool cohesion cyber infrastructure data harmonization data mining data sharing experimental study meetings member multidisciplinary operation programs single-cell RNA sequencing success symposium synergism terabyte videoconference wiki

项目摘要

CORE A- Abstract The success of multidisciplinary, multi-investigator scientific programs critically depends not only on the scientific quality of the individual research programs and their thematic synergy, but equally on the ability of the group to work together and to stay on course to accomplish larger goals of the common endeavor. Even greater scientific advancements are possible if teams can enhance the quality of science by cross-fertilization of ideas and the potential to draw new conclusions from cross-analysis of data contributed by studying different components of the same system (organism). Coordination of the above issues is particularly critical when the area of research lies at an interface of two complex disciplines, as is clearly the case with research at the interface of immunology and gerontology. All of the above necessitates a deliberate and systematic approach to ensure Program success at all levels. To that effect, the Scientific Integration and Administration Core (Core A) will be the nerve center of the Program, coordinating every aspect of its scientific and administrative progress. Specific Aims are to: SA1. Ensure scientific communication and exchange via: (i) regular monthly group videoconference meetings; (ii) a common and interactive experimental planning and data sharing space – the Thymus Rejuvenation PPG GoogleDoc platform and (iii) annual in-person PPG progress meetings. This Core will also organize and promote animal, tissue and reagent sharing via the above three means. SA2. Ensure fiscal and administrative oversight by monitoring spending with regard to specific aims and productivity of individual Projects and ensure timely annual reporting to the sponsor. SA3. Organize and implement scientific oversight. via (i) an internal PPG Scientific Steering Committee (PSSC), consisting of Project Leaders; and (ii) an external advisory board (EAB) composed of three scientists with strong expertise in the areas of the Program. SA 4. Provide coordinated data and knowledge sharing and management platforms (DKMP) to enable the distributed team members to securely share and harmonize data; to facilitate documentation of experimental progress and results; and to share laboratory protocols and analytic tools. This SA will oversee coordination of experimental data flowing to Core B that will be optimized via controlled ontologies, standardized meta-data collection, and common ID conventions to facilitate data mining, and cross-discovery between P1-P3. A Project Management Platform (PMP) utilizing GoogleDocs and Wiki technologies will facilitate inter-Project and Core interactions and delivery of Program goals under the guidance of the PSSC (see SA3). Of particular importance are the integration of single cell RNA-Seq data across projects, that will be integral for answering Program-level hypotheses. This Core will therefore foster scientific integration at the highest level, while providing administrative cohesion.

核心A-摘要