Core A Scientific and Administrative Integration: Thymic and peripheral Aspects of T cell Aging and Rejuvenation

多学科、多研究者科学计划的成功关键不仅取决于 个人研究项目的科学素质及其主题协同作用，但同样取决于 小组共同努力，继续前进，以实现共同努力的更大目标。连 如果团队能够通过交叉受精来提高科学质量，就有可能取得更大的科学进步 通过对不同研究贡献的数据进行交叉分析，得出新结论的可能性 同一系统(有机体)的组成部分。上述问题的协调在以下情况下尤为关键 研究领域处于两个复杂学科的交界处，免疫学和 老年学研究。以上所有这些都需要一个深思熟虑和系统的方法来确保计划 各层次的成功。 为此，科学整合和管理核心(核心A)将成为 计划，协调其科学和管理进展的方方面面。具体目标是： SA1.通过以下方式确保科学沟通和交流：(I)每月定期举行集体视频会议 会议；(2)共同和互动的实验规划和数据共享空间--胸腺 年轻化PPG维基和(Iii)年度面对面PPG进度会议。THES CORE还将组织 并通过上述Wiki促进动物、组织和试剂的共享。 SA2.通过监测与具体目标有关的支出，确保财政和行政监督 并确保及时向赞助商提交年度报告。 SA3.组织实施科学监督。通过(I)内部PPG科学指导委员会 (2)由3-4人组成的外部咨询委员会(EAB) 在该计划领域拥有丰富专业知识的科学家。 SA 4.提供协调一致的数据和知识共享及管理平台，以使 分散的团队成员安全地共享和管理数据集；并允许团队记录 实验进展和结果，并共享实验室方案和数据集。该SA还将主办和 执行Micasa形态测量软件的版本控制，并通过以下方式组织项目人员培训 1名工作人员。平台将与核心B的需求保持一致，并将通过受控方式进行优化 本体、标准化的元数据收集和通用ID约定，以促进数据挖掘、交叉 受精和交叉发现，通过回答由 计划科学指导委员会。 因此，这一核心将促进最高级别的科学整合，同时提供行政凝聚力。

The success of multidisciplinary, multi-investigator scientific programs critically depends not only on the scientific quality of the individual research programs and their thematic synergy, but equally on the ability of the group to work together and to stay on course to accomplish larger goals of the common endeavor. Even greater scientific advancements are possible if teams can enhance the quality of science by cross-fertilization of ideas and the potential to draw new conclusions from cross-analysis of data contributed by studying different components of the same system (organism). Coordination of the above issues is particularly critical when the area of research lies at an interface of two complex disciplines, as is clearly the case with immunology and gerontology research. All of the above necessitates a deliberate and systematic approach to ensure Program success at all levels. To that effect, the Scientific Integration and Administration Core (Core A) will be the nerve center of the Program, coordinating every aspect of its scientific and administrative progress. Specific Aims are to: SA1. Ensure scientific communication and exchange via: (i) regular monthly group videoconference meetings; (ii) a common and interactive experimental planning and data sharing space – the Thymus Rejuvenation PPG Wiki and (iii) annual in-person PPG progress meetings. Thes Core will also organize and promote animal, tissue and reagent sharing via the above Wiki. SA2. Ensure fiscal and administrative oversight by monitoring spending with regard to specific aims and productivity of individual Projects and ensure timely annual reporting to the sponsor. SA3. Organize and implement scientific oversight. via (i) an internal PPG Scientific Steering Committee (PSSC), consisting of Project Leaders; and (ii) an external advisory board (EAB) composed of 3-4 scientists with strong expertise in the area of the Program. SA 4. Provide coordinated data and knowledge sharing and management platforms to enable the distributed team members to securely share and manage data sets ; and to allow teams to document experimental progress and results, and share laboratory protocols and datasets. This SA will also host and perform version control of MiCASA morphometric software and organize training of Program personnel by P1 staff. The platforms will be aligned to the needs of Core B and will be optimized via controlled ontologies, standardized meta-data collection, and common ID conventions to facilitate data mining, cross- fertilization and cross-discovery, by answering a series of specific inter-project questions formulated by the Program Scientific Steering Committee. This Core will therefore foster scientific integration at the highest level, while providing administrative cohesion.