Developmental Research Program

项目摘要（医学研究） 对发展研究项目的支持是SPORE的一个关键要素， 促进开拓性举措。因此，我们将支持3个发展研究项目， 每年预算约5万元。发展的主要目标 研究计划（DRP）是支持高度创新的放射治疗相关的癌症 具有高转化影响潜力的研究，使研究人员能够 获取提交R 01申请或同等申请的关键初步数据 提案（例如未来SPORE应用中的项目）。最多两年的支持将是 可能;但是，预计资金将支持大多数项目一年， 在赠款的五年期内支持10-15个新项目。将征集项目 来自密歇根大学罗格癌症中心的研究人员和其他密歇根大学 教师通过校园范围内的公告和该计划的常设广告在 癌症中心和机构网站列出其他发展研究的机会。 申请将使用NIH格式，申请正文限制为5页（例如： 不包括参考文献、详细的方案信息、附录材料）。Eric Fearon博士和 西奥多劳伦斯将担任DRP的联合董事。癌症研究 密歇根大学罗格癌症中心委员会将进行初步审查， 评估每个提案的科学价值，创新性，与主题的相关性， 局部晚期癌症的放射增敏和潜在的转化影响。给定 癌症研究委员会对100多个试点项目进行了快速而成功的年度审查， 每年在实验室，临床和人口为基础的研究， 委员会非常适合初步审查进程。经过初步审查，SPORE的 行动委员会将利用分配的成绩分数作为主要标准，但不是唯一标准， 选择支持提案。发展研究项目研究人员将参加 所有的活动。费伦博士或劳伦斯博士将加入为每个人设立的指导委员会。 项目PI提供深入的审查和指导。

PROJECT SUMMARY-ABSTRACT (DEVELOPMENTAL RESEARCH PROGRAM) Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As such, we will support 3 developmental research projects with budgets of approximately $50,000 each per year. The principal goal of the Developmental Research Program (DRP) is to support highly innovative radiation therapy related cancer research with high potential for translational impact, allowing investigators the ability to obtain key preliminary data for submission of an R01 application or an equivalent proposal (e.g. project in future SPORE application). A maximum of two years of support will be possible; however, the expectation is that funds will support most projects for one year, with 10-15 new projects supported during the five-year period of the grant. Projects will be solicited from University of Michigan Rogel Cancer Center investigators and other University of Michigan faculty by campus-wide announcements and a standing advertisement for the Program at the Cancer Center and institutional websites listing other developmental research opportunities. Applications will utilize an NIH format, with a 5-page limit on the body of the application (e.g. excluding references, detailed protocol information, appendix materials). Drs. Eric Fearon and Theodore Lawrence will serve as Co-Directors of the DRP. The Cancer Research Committee of the University of Michigan Rogel Cancer Center will undertake initial review, evaluating each proposal’s scientific merit, innovation, relevance to the theme of radiosensitization of locally advanced cancers and potential for translational impact. Given the Cancer Research Committee’s rapid and successful annual review of more than 100 pilot research proposals yearly in laboratory, clinical, and population-based research, the Committee is well-suited for the initial review process. After initial review, the SPORE’s Operations Committee will utilize assigned merit scores as a principal, but not sole, criterion in the selection of proposals for support. Developmental research project investigators will take part in all SPORE activities. Drs. Fearon or Lawrence will join mentoring committees set up for each project PI to offer in-depth review and mentorship.