Developmental Research Program

项目摘要-摘要(发展研究方案) 对发展研究项目的支持是一个关键的孢子要素，对 培养开拓性的主动性。因此，我们将支持3个发展研究项目，包括 预算每人每年约50,000美元。发展的首要目标 研究计划(DRP)旨在支持与癌症相关的高度创新的放射治疗 具有很高翻译影响潜力的研究，使调查人员能够 获取用于提交R01申请或类似申请的关键初步数据 建议(例如，未来孢子应用的项目)。最多两年的支持将是 有可能；然而，预计资金将支持大多数项目一年， 在赠款的五年期间，资助了10-15个新项目。将征集项目 来自密歇根大学罗杰尔癌症中心的研究人员和密歇根大学的其他人 教员通过校园范围的公告和该项目的长期广告 癌症中心和机构网站列出了其他发展研究机会。 应用程序将使用NIH格式，应用程序正文以5页为限(例如 不包括参考文献、详细的议定书信息、附录材料)。Eric Fearon博士和 西奥多·劳伦斯将担任DRP的联席主任。癌症研究 密歇根大学罗杰尔癌症中心委员会将进行初步审查， 评估每个提案的科学价值、创新、与主题的相关性 局部晚期癌症的放射增敏和潜在的翻译影响。vt.给出 癌症研究委员会对100多名飞行员的快速和成功的年度审查 每年在实验室、临床和基于人群的研究中的研究建议 委员会非常适合进行最初的审查过程。经过初步审查，该孢子的 运营委员会将使用分配的优秀分数作为主要标准，但不是唯一的标准 选定要支持的建议。发展研究项目调查员将参加 所有的孢子活动。Fearon博士或Lawrence博士将加入为每个人设立的指导委员会 项目PI提供深入的审查和指导。

PROJECT SUMMARY-ABSTRACT (DEVELOPMENTAL RESEARCH PROGRAM) Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As such, we will support 3 developmental research projects with budgets of approximately $50,000 each per year. The principal goal of the Developmental Research Program (DRP) is to support highly innovative radiation therapy related cancer research with high potential for translational impact, allowing investigators the ability to obtain key preliminary data for submission of an R01 application or an equivalent proposal (e.g. project in future SPORE application). A maximum of two years of support will be possible; however, the expectation is that funds will support most projects for one year, with 10-15 new projects supported during the five-year period of the grant. Projects will be solicited from University of Michigan Rogel Cancer Center investigators and other University of Michigan faculty by campus-wide announcements and a standing advertisement for the Program at the Cancer Center and institutional websites listing other developmental research opportunities. Applications will utilize an NIH format, with a 5-page limit on the body of the application (e.g. excluding references, detailed protocol information, appendix materials). Drs. Eric Fearon and Theodore Lawrence will serve as Co-Directors of the DRP. The Cancer Research Committee of the University of Michigan Rogel Cancer Center will undertake initial review, evaluating each proposal’s scientific merit, innovation, relevance to the theme of radiosensitization of locally advanced cancers and potential for translational impact. Given the Cancer Research Committee’s rapid and successful annual review of more than 100 pilot research proposals yearly in laboratory, clinical, and population-based research, the Committee is well-suited for the initial review process. After initial review, the SPORE’s Operations Committee will utilize assigned merit scores as a principal, but not sole, criterion in the selection of proposals for support. Developmental research project investigators will take part in all SPORE activities. Drs. Fearon or Lawrence will join mentoring committees set up for each project PI to offer in-depth review and mentorship.