Multidisciplinary Research Training in Sleep Science

项目概要/摘要 睡眠和昼夜节律紊乱对公众健康的意义是广泛的，因为它对身体和精神的影响 健康这些疾病的高患病率使得为新的研究者提供一个强大的渠道变得至关重要， 应对理解所涉及的机制的挑战，它们对心血管，代谢，肺 和神经退行性系统，并开发和测试干预措施。伊坎医学院（ISMMS） 纽约大学格罗斯曼医学院（NYU）来自多个部门（睡眠医学，肺， 精神病学，神经科学，放射学，人口健康，心脏病学和生物统计学）已经参与了合作， 几十年来，睡眠和昼夜节律科学的基础和临床研究。我们的培训计划将建立在 成功的指导研究和培训计划的基础（例如纽约大学的PRIDE研究所）， 获得资助的调查人员必须表现出对职业发展的坚定承诺。当前的领域 研究包括（但不限于）（i）生物钟的基础生物学，（ii）生物钟作用的转化研究， 睡眠记忆，（iii）临床面向患者的研究，评估阻塞性睡眠呼吸暂停（OSA）的生理学，其 治疗和评估OSA对心血管和大脑健康的影响（iv）开发模拟和网络 帮助教授睡眠生理学。最先进的生理和成像技术（心脏CT 成像、PET/MR脑成像、阿尔茨海默病生物流体生物标志物），并且包括跨研究领域的受试者。 年龄范围（儿童到老年人）和少数群体。我们将利用现有的培训 这两个机构的基础设施沿着过去10年的成功合作经验 在两个机构的多学科教师之间，并纳入翻译内容，以培养博士后 伙计们这个为期5年的计划的目的是招募和培养共6名博士后候选人（医生科学家或 博士毕业生）。学员将参加一个2-3年的计划，在此期间，他们被分配到一个指导 团队，包括一个主要的，次要的和同行的导师。导师是国家认可的调查人员， 在指导学员发展职业生涯和提交成功的助学金申请方面具有专业知识。学员将 实施个人发展计划，利用现有会议、教学课程和技术相结合， 协助举办多机构讲习班，以获得专业的、基于实验室的技能和负责任行为方面的培训 研究。学员将有机会获得这两个机构的广泛培训和研究支助资源 包括CTSI/CTSA。可衡量的成果将包括学员出版物、演讲和赠款 应用.学员10年后的成就也将被评估，包括学术领导力 职位、职业奖励、联邦和非联邦赠款以及参与辅导活动。睡眠科学T32 该计划解决了睡眠和昼夜节律研究人员的需求，并促进他们向独立过渡。

Project Summary/Abstract The significance of sleep and circadian disorders on public health is broad because of its effects on physical and mental health. The high prevalence of these disorders makes it critical that a robust pipeline exists for new investigators to tackle the challenge of understanding the mechanisms involved, their impact on cardiovascular, metabolic, pulmonary and neurodegenerative systems and develop and test interventions. Faculty at Icahn School of Medicine (ISMMS) and New York University Grossman School of Medicine (NYU) from multiple departments (sleep medicine, pulmonary, psychiatry, neuroscience, radiology, population health, cardiology, and biostatistics) have been involved in collaborative basic and clinical research in sleep and circadian science for several decades. Our training program will build on the foundation of successful mentored research and training programs (e.g. PRIDE institute at NYU) with experienced, well- funded investigators who have demonstrated a strong commitment for career development. The areas of current research include (but are not limited to) (i) basic biology of the circadian clock, (ii) translational research on the role of sleep on memory, (iii) clinical patient oriented research evaluating physiology of obstructive sleep apnea (OSA), its treatment and evaluation of outcomes of OSA on cardiovascular and brain health (iv) developing simulation and web based tools to assist teaching sleep physiology. State of the art physiological and imaging techniques (cardiac CT imaging, PET/MR brain imaging, Alzheimer’s disease biofluid biomarkers) are employed, and include subjects across the age spectrum (pediatric to elderly populations) and minority populations. We will leverage access to the existing training infrastructure at the two institutions along with the experience of successful collaborations over the past 10 years between multidisciplinary faculty at the two institutions and incorporate translational content to train post-doctoral fellows. The aim of this 5-year program is to recruit and train a total of 6 postdoctoral candidates (physician scientists or PhD graduates). Trainees will participate in a 2-3 year program during which time they are assigned to a mentoring team, comprised of a primary, secondary and peer mentor. Mentors are nationally recognized investigators with expertise in guiding mentees in developing their careers and in submitting successful grant applications. Trainees will implement an Individual Development Plan, use a combination of existing conferences, didactic courses and technology- assisted multi-institutional workshops to acquire professional, laboratory based skills and training in responsible conduct of research. Trainees will have access to the broad training and research support resources of the two institutions including those of the CTSI/CTSA. Measurable outcomes will include trainee publications, presentations, and grant applications. Mentees’ achievements for 10 years post program will also be evaluated and include academic leadership positions, career awards, federal and non- federal grants and engagement in mentoring activities. The Sleep Science T32 Program addresses the need for sleep and circadian researchers and facilitates their transition to independence.