Multidisciplinary Research Training in Sleep Science

项目摘要/摘要 睡眠和昼夜节律紊乱对公共健康的意义是广泛的，因为它对身体和精神都有影响。 健康。这些疾病的高流行率使得为新的调查人员提供强大的渠道至关重要 应对了解相关机制及其对心血管、代谢、肺功能的影响的挑战 和神经退化系统，并开发和测试干预措施。伊坎医学院(ISMMS)和 纽约大学格罗斯曼医学院(NYU)来自多个科室(睡眠医学、肺科、 精神病学、神经科学、放射学、人口健康、心脏病学和生物统计学)参与了合作 几十年来在睡眠和昼夜节律科学方面的基础和临床研究。我们的培训计划将建立在 成功的导师研究和培训项目的基础(例如纽约大学的Pride Institute)，拥有经验丰富的 资助那些对职业发展表现出强烈承诺的调查人员。洋流的区域 研究包括(但不限于)(I)生物钟的基础生物学，(Ii)关于生物钟的作用的翻译研究 记忆中的睡眠，(Iii)评估阻塞性睡眠呼吸暂停(OSA)生理学的临床患者研究，其 阻塞性睡眠呼吸暂停综合征对心血管和脑健康的治疗和疗效评价(IV)开发模拟和网络 基于辅助睡眠生理学教学的工具。最先进的生理和成像技术(心脏CT 成像、PET/MR脑成像、阿尔茨海默病生物流体生物标志物)，包括 年龄谱(从儿童到老年人口)和少数民族人口。我们将利用对现有培训的访问 两个机构的基础设施以及过去10年成功合作的经验 两个机构的多学科教师之间的合作，并纳入翻译内容以培养博士后 伙计们。这一为期5年的计划的目标是招聘和培训总共6名博士后候选人(医生、科学家或 博士毕业生)。学员将参加一个2-3年的计划，在此期间，他们将被分配到指导中 团队，由主要导师、次要导师和同伴导师组成。导师是全国公认的调查人员，拥有 在指导被辅导者发展其职业生涯和提交成功的资助申请方面的专业知识。实习生将 实施个人发展计划，结合现有会议、授课课程和技术- 协助多机构讲习班，以获得专业的、基于实验室的技能和负责任的行为培训 研究的成果。学员将有机会获得两所院校广泛的培训和研究支持资源。 包括CTSI/CTSA。可衡量的成果将包括实习生出版物、演示文稿和赠款 申请。学员在10年岗位计划中的成就也将被评估，其中包括学术领导力 职位、职业奖励、联邦和非联邦赠款以及参与指导活动。睡眠科学T32 该计划解决了睡眠和昼夜节律研究人员的需求，并促进了他们向独立的过渡。

Project Summary/Abstract The significance of sleep and circadian disorders on public health is broad because of its effects on physical and mental health. The high prevalence of these disorders makes it critical that a robust pipeline exists for new investigators to tackle the challenge of understanding the mechanisms involved, their impact on cardiovascular, metabolic, pulmonary and neurodegenerative systems and develop and test interventions. Faculty at Icahn School of Medicine (ISMMS) and New York University Grossman School of Medicine (NYU) from multiple departments (sleep medicine, pulmonary, psychiatry, neuroscience, radiology, population health, cardiology, and biostatistics) have been involved in collaborative basic and clinical research in sleep and circadian science for several decades. Our training program will build on the foundation of successful mentored research and training programs (e.g. PRIDE institute at NYU) with experienced, well- funded investigators who have demonstrated a strong commitment for career development. The areas of current research include (but are not limited to) (i) basic biology of the circadian clock, (ii) translational research on the role of sleep on memory, (iii) clinical patient oriented research evaluating physiology of obstructive sleep apnea (OSA), its treatment and evaluation of outcomes of OSA on cardiovascular and brain health (iv) developing simulation and web based tools to assist teaching sleep physiology. State of the art physiological and imaging techniques (cardiac CT imaging, PET/MR brain imaging, Alzheimer’s disease biofluid biomarkers) are employed, and include subjects across the age spectrum (pediatric to elderly populations) and minority populations. We will leverage access to the existing training infrastructure at the two institutions along with the experience of successful collaborations over the past 10 years between multidisciplinary faculty at the two institutions and incorporate translational content to train post-doctoral fellows. The aim of this 5-year program is to recruit and train a total of 6 postdoctoral candidates (physician scientists or PhD graduates). Trainees will participate in a 2-3 year program during which time they are assigned to a mentoring team, comprised of a primary, secondary and peer mentor. Mentors are nationally recognized investigators with expertise in guiding mentees in developing their careers and in submitting successful grant applications. Trainees will implement an Individual Development Plan, use a combination of existing conferences, didactic courses and technology- assisted multi-institutional workshops to acquire professional, laboratory based skills and training in responsible conduct of research. Trainees will have access to the broad training and research support resources of the two institutions including those of the CTSI/CTSA. Measurable outcomes will include trainee publications, presentations, and grant applications. Mentees’ achievements for 10 years post program will also be evaluated and include academic leadership positions, career awards, federal and non- federal grants and engagement in mentoring activities. The Sleep Science T32 Program addresses the need for sleep and circadian researchers and facilitates their transition to independence.