Impact of intestinal helminth infection on HPV co-infection and the cervico-vaginal environment.

肠道蠕虫感染对 HPV 合并感染和宫颈阴道环境的影响。

• 批准号: 10554434
• 负责人: Eva H Clark
• 金额: $ 18.38万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-24 至 2026-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554434
• 关键词: Adult; Advisory Committees; Affect; Authorization documentation; Biological; Biological Assay; Cancer Etiology; Cervical; Cervical Cancer Screening; Cervical dysplasia; Cessation of life; Childhood; Chronic; Clinical; Clinical Research; Communicable Diseases; Communities; Country; Cross-Sectional Studies; Data; Detection; Development; Development Plans; Environment; Epidemiologist; Epithelial Cells; Female; Funding; Goals; Health; Health system; Helminths; Helper-Inducer T-Lymphocyte; High Risk Woman; Human Papilloma Virus Vaccination; Human Papillomavirus; Human papilloma virus infection; Immune; Immune response; Immunity; Immunization Programs; Immunologics; International; Intervention; Intestines; K-Series Research Career Programs; Lactobacillus; Large Intestine; Link; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mediating; Medicine; Mentors; Mentorship; Molecular; Parasitology; Pathway interactions; Persons; Peru; Physicians; Population; Prevalence; Prevention strategy; Public Health; Regulatory T-Lymphocyte; Research; Resource-limited setting; Resources; Risk; Scientist; Soil; Specimen; Structure; Swab; T cell response; Teacher Professional Development; Technology; Testing; Training; Training Activity; Tropical Medicine; United States National Institutes of Health; Vaccination; Vagina; Virus; Whole-Genome Shotgun Sequencing; Woman; Work; authority; cancer risk; career; career development; cervical cancer prevention; cervicovaginal; cervicovaginal microbiome; chronic infection; co-infection; college; cost; cytokine; disability; dysbiosis; global health; helminth infection; high risk; improved; infection risk; innovation; intervention cost; low and middle-income countries; meetings; microbiome; microbiota; novel; older women; polarized cell; prevent; professor; programs; reproductive tract; screening; screening program; skills; transmission process; treatment program

Project Summary Dr. Clark is an Assistant Professor of Pediatric Tropical Medicine and Infectious Diseases at Baylor College of Medicine (BCM) and a physician-scientist trained in immunoparasitology. Her career goal is to become an independent molecular epidemiologist and perform high-quality clinical research that improves the health of people living in low resource settings. The leading cause of cancer death for women in tropical low- and middle-income countries (LMICs) is cervical cancer, which is caused by persistent infection with the human papilloma virus (HPV). Cervical cancer rates are particularly high in LMICs with large intestinal helminth burdens, and preliminary data show a significant population level association between intestinal helminth infection and HPV infection. Dr. Clark proposes to evaluate whether intestinal helminth infection facilitates HPV co-infection by altering the cervico-vaginal environment. She will conduct a cross-sectional study of adult women undergoing cervical cancer screening in Peru. This innovative study aims to determine the prevalence of HPV infection, evaluate cervico-vaginal cytokine profiles, and examine the distribution of cervico-vaginal microbiota in women with and without intestinal helminth infection. Results of this work will suggest novel interventions that are urgently needed to prevent cervical cancer in women living in LMICs. Dr. Clark’s unique skill set will allow her to serve as a link between clinical discovery and public health system implementation of new strategies for cervical cancer prevention. From a public health perspective, if intestinal helminth infection increases a woman’s risk for HPV infection and therefore cervical cancer, deworming—a widely available, low- cost intervention—should reduce the cervical cancer rates, thereby increasing the feasibility of cervical cancer screening program implementation and reducing costs associated with early cervical dysplasia detection and treatment programs. To accomplish these goals, Dr. Clark has developed a comprehensive career development plan that combines thorough mentoring and training activities integrated into her clinical research program. She will have regular meetings with her mentorship team, Dr. Elizabeth Chiao, an authority in virus mediated malignancies and HPV screening, and Dr. Peter Hotez, a leader in parasitology and global health, and will receive additional expert-level mentorship from her scientific advisory committee. Mentored research will be supplemented with formal training activities including graduate-level coursework, directed studies, ad participation in scientific meetings. Her career development plan is supported by a world-class scientific environment at BCM, which offers ample opportunities for junior faculty development and provides all the resources needed to achieve her career goals. The proposed mentored career development activities will provide the focused mentorship and career development activities that Dr. Clark requires to succeed as an independently funded molecular epidemiologist conducting high quality, high impact international research.

项目摘要 博士克拉克是贝勒学院儿科热带医学和传染病助理教授 一名接受过免疫寄生虫学培训的医生兼科学家。她的职业目标是成为一名 独立的分子流行病学家，并进行高质量的临床研究，改善健康的 生活在低资源环境中的人们。热带低海拔地区妇女癌症死亡的主要原因是 中等收入国家（LMICs）的宫颈癌是由人类持续感染引起的。 乳头瘤病毒（HPV）。宫颈癌的发病率在有大肠蠕虫的低收入国家特别高 初步数据显示，肠道蠕虫和肠道寄生虫之间存在显著的群体水平相关性， 感染和HPV感染。克拉克博士建议评估肠道蠕虫感染是否有利于HPV 通过改变子宫颈阴道环境而引起的共同感染。她将对成年人进行一项横断面研究， 在秘鲁接受宫颈癌筛查的妇女。这项创新研究旨在确定 HPV感染，评估宫颈阴道细胞因子谱，并检查宫颈阴道细胞因子的分布。 肠道寄生虫感染和未感染的女性中的微生物群。这项工作的结果将表明新的 迫切需要采取干预措施，以预防生活在中低收入国家的妇女患宫颈癌。克拉克博士的独特之处 她的技能将使她成为临床发现和公共卫生系统实施之间的纽带， 预防宫颈癌的新策略。从公共卫生的角度来看，如果肠道蠕虫感染 增加了妇女感染HPV的风险，因此增加了宫颈癌的风险， 成本干预--应降低宫颈癌发病率，从而增加宫颈癌的可行性 筛查计划的实施和降低与早期宫颈发育不良检测相关的成本， 治疗方案。为了实现这些目标，克拉克博士发展了一个全面的职业生涯， 将全面的指导和培训活动结合到她的临床研究中的发展计划 程序.她将定期与她的导师团队--病毒领域的权威焦雅玲博士会面。 介导的恶性肿瘤和HPV筛查，以及寄生虫学和全球健康领域的领导者Peter Hotez博士， 并将从她的科学咨询委员会获得额外的专家级指导。指导研究 将辅以正式的培训活动，包括研究生水平的课程，指导研究，广告 参加科学会议。她的职业发展计划得到了世界级科学家的支持， 环境，这为初级教师的发展提供了充足的机会，并提供了所有的 他需要的资源来实现他的职业目标。拟议的辅导职业发展活动将 提供克拉克博士作为一个成功的职业发展所需的重点指导和职业发展活动， 独立资助的分子流行病学家进行高质量，高影响力的国际研究。