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PharmGKB

药学知识库

基本信息

批准号：
10555356
负责人：
TERI Ellen KLEIN
金额：
$ 150万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-03 至 2025-12-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10555356
关键词：
Academia Adverse effects Adverse event Area Basic Science Binding Catalogs ClinVar Clinic Clinical Clinical Research Collaborations Communities Complement Computer software Computing Methodologies DNA Data Dedications Development Devices Discipline Disease Dose Drug Kinetics Drug Prescriptions Environment FAIR principles Funding Generations Genes Genetic Genetic Variation Genetic study Genome Genomic medicine Genomics Guidelines Hair Color Health Height Human Human Genetics Individual Inherited International Intervention Knowledge Knowledge acquisition Label Laboratories Literature Measures Medical Medicine Methods Mission Molecular Molecular Biology National Human Genome Research Institute Pathway interactions Patients Pediatrics Persons Pharmaceutical Preparations Pharmacodynamics Pharmacogenetics Pharmacogenomics Pharmacology Phenotype Physiological Positioning Attribute Procedures Research Research Personnel Resources Rest Risk Role Rural Safety Source Testing Therapeutic Time Toxic effect Translational Research United States National Institutes of Health Variant Vision Work clinical care clinical implementation clinically significant computer infrastructure data integration data interoperability data sharing drug efficacy experience flexibility genome resource improved information organization knowledge integration knowledgebase novel outreach program pharmacokinetics and pharmacodynamics precision medicine programs public repository response side effect standard of care success synergism tool trait web page web site

项目摘要

Project Summary/Abstract Pharmacogenomics is the study of how genetic variation influences drug response phenotypes and is a pillar of precision medicine — choosing the right drug for the right patient at the right dose and time. A public resource of pharmacogenomics knowledge is critical — both to catalyze basic discovery of the molecular mechanisms that drive variability in drug response and to support the implementation of clinical research to understand how to best deliver pharmacogenomics in the clinic. The Pharmacogenomics Knowledgebase (PharmGKB) is the premier public repository of pharmacogenomics knowledge. PharmGKB curators focus on high quality extraction and representation of knowledge in the primary literature, and capture information about individual genetic variations that impact drug response, the potential clinical impact of these variations, the pharmacokinetic and pharmacodynamic pathways of drug response, the pharmacogenomic requirements in regulatory documents (labels), and guidelines for genome-driven prescribing. The PharmGKB website hosts annually on average 5.2 million webpage views (without bots) and provides flexible access to pharmacogenomics knowledge on multiple devices. Most importantly, PharmGKB serves as a hub for the research community in pharmacogenomics and precision medicine — integrating its contents with critical resources and organizations including ClinVar, the Clinical Genome Resource (ClinGen), the FDA, the Clinical Pharmacogenetics Implementation Consortium (CPIC) and others. In this proposal, we request support for PharmGKB as a Biomedical Knowledgebase, and outline a plan to (1) annotate, aggregate, integrate, and disseminate pharmacogenomic knowledge from sources utilizing community curation and semi-automated methods to assist knowledge acquisition, (2) build curation and user-specific interfaces that catalyze the discovery and use of pharmacogenomic knowledge, providing the content of our knowledgebase in novel ways that are useful to our users, (3) collaborate and integrate with ongoing national and international efforts dedicated to the implementation of genomic medicine by providing the best scientific knowledge to support these important programs and (4) develop a new long-term and conceptual framework for broadly integrating available PGx knowledgebases into genomic medicine.

项目总结/文摘