The Neurobiology of Drug Abuse

药物滥用的神经生物学

• 批准号: 10555567
• 负责人: SARA RAULERSON JONES
• 金额: $ 21.52万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10555567
• 关键词: Drug abuse; Neurobiology

NEUROBIOLOGY OF DRUG ABUSE TRAINING PROGRAM SUMMARY One of the keys to developing effective prevention and treatment strategies for substance use disorder is understanding the neurobiological consequences of chronic exposure to drugs of abuse. Such studies must involve multi-disciplinary approaches to examine several different levels of brain function. This is the goal of our current training program, the Neurobiology of Drug Abuse Training Program, which proposes to continue a successful tradition of NIDA training at Wake Forest School of Medicine (WFSM). This program requests funding to train five predoctoral students in a multi-disciplinary program in the neurobiology of drug abuse. The program includes 24 faculty members at WFSM, with research interests spanning molecular biology, receptor pharmacology, brain imaging techniques in humans and non-human primates, electrophysiology, neuronal activity monitoring and behavioral analysis of drug self- administration. The research of the faculty is supported by a significant number of federally-funded grants related to the field of substance abuse. The training program is organized around three principal areas of research: Molecular/Cellular Neurobiology, Neurobiological Systems, and Behavioral Neurobiology. The training program offers a specific course in drug abuse covering topics related to each of these three areas. Predoctoral students have a choice of two different Ph.D. degree tracks: Integrated Physiology/Pharmacology and Neuroscience. Although these programs have their own individual requirements, specific drug abuse-related topics are integrated into the standard programs. The training program offers specific seminars and journal clubs for trainees and opportunities for additional substance abuse training. The program also contains specialized components dealing with statistics/data analytics, grant writing, rigor and transparency in research, and ethics in scientific research. Recruitment of students will be aided by the fact that the field of neuroscience is one of the fastest growing disciplines in the biological sciences, and WFSM is undergoing a strong research growth phase. In addition, recruitment of applicants from under- represented minorities will be a high priority, including undergraduate training programs with Winston Salem State University, North Carolina A&T University and North Carolina Central University. In summary, the Neurobiology of Drug Abuse Training Program not only offers students outstanding opportunities for education and research in the neurobiology of drug abuse but is also a valuable resource for the field of drug abuse by providing trained young investigators capable of independent scientific careers.

药物滥用培训计划的神经生物学摘要 制定有效的预防和治疗策略的关键之一是 了解长期暴露于滥用药物的神经生物学后果。这样的研究必须 涉及多学科方法，以检查几种不同级别的大脑功能。这是 我们当前的培训计划，“药物滥用培训计划的神经生物学”，该计划提议继续 Wake Forest医学院（WFSM）的NIDA培训的成功传统。此程序请求 资助在药物滥用神经生物学的多学科课程中培训五名专业学生。这 计划包括WFSM的24名教职员工，具有分子生物学，受体的研究兴趣 药理学，人类和非人类灵长类动物的脑成像技术，电生理学，神经元 药物自我给药的活动监测和行为分析。教师的研究是 得到与药物滥用领域有关的大量联邦资助赠款的支持。这 培训计划围绕三个主要研究领域组织：分子/细胞神经生物学， 神经生物学系统和行为神经生物学。培训计划提供了特定的药物课程 滥用涵盖与这三个领域相关的主题。专业学生有两个不同的选择 博士学位轨道：综合生理学/药理学和神经科学。尽管这些程序有 他们自己的个人要求，与毒品滥用有关的特定主题已纳入标准 程序。该培训计划为学员提供特定的研讨会和期刊俱乐部，并提供机会 其他药物滥用培训。该计划还包含有关专门的组件 统计/数据分析，研究研究中的赠款，严格和透明度以及科学研究中的道德规范。 神经科学领域是成长最快的事实，将有助于学生的招聘 生物科学和WFSM的学科正在经历强大的研究增长阶段。此外， 少数族裔不足少数族裔的申请人的招募将是高度优先事项，包括本科生 Winston Salem州立大学，北卡罗来纳州A＆T大学和北卡罗来纳州的培训计划 中央大学。总而言之，药物滥用培训计划的神经生物学不仅为学生提供 在药物滥用神经生物学方面的教育和研究的杰出机会，但也是有价值的 通过提供能够独立科学的训练有素的年轻调查人员，用于滥用药物滥用领域的资源 职业。

项目成果

Genetic variation in satiety signaling and hypothalamic inflammation: merging fields for the study of obesity.

• DOI: 10.1016/j.jnutbio.2021.108928
• 发表时间: 2022-03
• 期刊: The Journal of nutritional biochemistry
• 作者: Szalanczy AM;Key CC;Solberg Woods LC
• 通讯作者: Solberg Woods LC

Atorvastatin Modulates the Function and Trafficking of Dopamine Transporters.

阿托伐他汀调节多巴胺转运蛋白的功能和运输。

• 发表时间: 2022
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Roberts,Jonté;Wang,Sherry;Medrano,Mar;Sun,Haigou;Chen,Rong
• 通讯作者: Chen,Rong