Histology/Imaging Core C
组织学/成像核心 C
基本信息
- 批准号:10555242
- 负责人:
- 金额:$ 23.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-02-15 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:Animal ModelAnimalsAntigensAreaBioluminescenceClinicClinical ResearchCollaborationsComputer softwareConsultationsDigestive System DisordersDisease MarkerDocumentationEducationExperimental Animal ModelFluorescenceFoundationsFundingGoalsHistologicHistologyHumanHuman ResourcesImageImage AnalysisImaging technologyImmunofluorescence ImmunologicImmunohistochemistryIndividualInflammationInflammatoryInvestigationLabelLaboratoriesLeadershipLiverLiver diseasesMagnetic Resonance ImagingMedical centerMetabolic DiseasesMetabolismMethodologyMethodsMorphologyPathologistPathologyPositron-Emission TomographyProductionProtocols documentationPublic DomainsPublicationsRadiology SpecialtyRapid screeningResearchResearch PersonnelResolutionRetrievalRoentgen RaysScientific Advances and AccomplishmentsServicesSignal TransductionSlideSpecimenStainsStructureSystemTechnologyTechnology TransferTimeTissue BanksTissue SampleTissuesTrainingUnited States National Institutes of HealthUniversitiesUniversity Hospitalsanimal imaginganimal tissueantigen detectioncostcost effectivedesigndigitaldigital pathologyexperienceexperimental studygastrointestinalimaging facilitiesin situ imagingin vivomembernoveloptical imagingpathology imagingpreclinical imagingpreclinical studyprogramsrepositorysingle photon emission computed tomographytumorigenesistumorigenic
项目摘要
HISTOLOGY/IMAGING CORE C PROJECT SUMMARY
The overall objective of the Histology/Imaging Core of the Cleveland DDRCC is to provide high-quality
morphologic analyses of the gastrointestinal and liver systems in experimental animal models and human GI
and liver-related pathologies. In addition, a major goal of the Histology/Imaging Core is to support new and
established investigators at Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation
(CCF), who do not have a direct focus on digestive disease-related research, to enter this exciting field of
investigation and to encourage collaborations among DDRCC members working in the areas of digestive
inflammation and metabolism. The Histology/Imaging Core continues to be committed to provide basic and
fundamental histology, with pathology interpretation and semi-quantitative scoring, as well as
immunohistochemical (IHC) and immunofluorescence (IF) methodologies essential to GI- and liver-related
research, while at the same time implementing state-of-the-art technologies, such as digital pathology and small
animal imaging of DDRCC investigators’ preclinical and clinical studies. Importantly, Histology/Imaging Core
personnel will provide valuable expert consultation and facilitate the training and transfer of Core technologies
to DDRCC investigators and their lab members to enhance GI- and liver-related research programs at CWRU
and CCF. The specific aims for the DDRCC Histology/Imaging Core are: 1) Provide histological analysis and
scoring of GI & liver diseases; 2) Provide immunohistochemistry (IHC) and/or immunofluorescence (IF) staining;
3) Provide small animal imaging; 4) Provide digital pathology, image analysis, and photodocumentation, and 5)
Provide consultation, education, training, and provision of archival tissues. Through these aims, the Cleveland
DDRCC Histology/Imaging Core will facilitate the production of high-quality research in digestive diseases in a
cost-effective and time-efficient manner, and enhance the rate, depth, and breadth of research in Digestive
Inflammation/Tumorigenesis and Liver Disease/Metabolism throughout CWRU and CCF, leading to
advancement of scientific discoveries in this important field of investigation.
组织学/成像核心C项目总结
克利夫兰DDRCC组织学/成像核心的总体目标是提供高质量的
实验动物模型和人胃肠道中胃肠道和肝脏系统的形态学分析
和肝脏相关的病理。此外,组织学/成像核心的主要目标是支持新的和
凯斯西储大学(CWRU)和克利夫兰诊所基金会的研究人员
(CCF),没有直接专注于消化系统疾病相关研究的人,进入这个令人兴奋的领域,
调查,并鼓励在消化领域工作的DDRCC成员之间的合作
炎症和新陈代谢。组织学/成像核心继续致力于提供基础和
基础组织学,病理学解释和半定量评分,以及
免疫组织化学(IHC)和免疫荧光(IF)方法对GI和肝脏相关
研究,同时实施最先进的技术,如数字病理学和小
DDRCC研究者临床前和临床研究的动物成像。重要的是,组织学/成像核心
人员将提供宝贵的专家咨询,促进核心技术的培训和转让
DDRCC研究人员及其实验室成员,以加强CWRU的GI和肝脏相关研究项目
和CCF。DDRCC组织学/成像核心的具体目标是:1)提供组织学分析,
2)提供免疫组织化学(IHC)和/或免疫荧光(IF)染色;
3)提供小动物成像; 4)提供数字病理学、图像分析和照片记录,以及5)
提供咨询、教育、培训和提供存档组织。通过这些目标,克利夫兰
DDRCC组织学/成像核心将促进在消化系统疾病的高质量研究的生产,
成本效益和时间效率的方式,并提高消化研究的速度,深度和广度
CWRU和CCF期间的炎症/肿瘤发生和肝脏疾病/代谢,导致
在这一重要研究领域的科学发现的进步。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Theresa Torres Pizarro其他文献
Theresa Torres Pizarro的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Theresa Torres Pizarro', 18)}}的其他基金
The pathogenic roles of GSDMD-dependent gut epithelium extracellular vesicles in IBD
GSDMD依赖性肠上皮细胞外囊泡在IBD中的致病作用
- 批准号:
10853519 - 财政年份:2023
- 资助金额:
$ 23.7万 - 项目类别:
The pathogenic roles of GSDMD-dependent gut epithelium extracellular vesicles in IBD
GSDMD依赖性肠上皮细胞外囊泡在IBD中的致病作用
- 批准号:
10386894 - 财政年份:2021
- 资助金额:
$ 23.7万 - 项目类别:
The pathogenic roles of GSDMD-dependent gut epithelium extracellular vesicles in IBD
GSDMD依赖性肠上皮细胞外囊泡在IBD中的致病作用
- 批准号:
10599251 - 财政年份:2021
- 资助金额:
$ 23.7万 - 项目类别:
The pathogenic roles of GSDMD-dependent gut epithelium extracellular vesicles in IBD
GSDMD依赖性肠上皮细胞外囊泡在IBD中的致病作用
- 批准号:
10211603 - 财政年份:2021
- 资助金额:
$ 23.7万 - 项目类别:
GSDMD-dependent IL-1 signaling in intestinal inflammation
肠道炎症中 GSDMD 依赖性 IL-1 信号传导
- 批准号:
10654589 - 财政年份:2020
- 资助金额:
$ 23.7万 - 项目类别:
GSDMD-dependent IL-1 signaling in intestinal inflammation
肠道炎症中 GSDMD 依赖性 IL-1 信号传导
- 批准号:
10223160 - 财政年份:2020
- 资助金额:
$ 23.7万 - 项目类别:
GSDMD-dependent IL-1 signaling in intestinal inflammation
肠道炎症中 GSDMD 依赖性 IL-1 信号传导
- 批准号:
10441357 - 财政年份:2020
- 资助金额:
$ 23.7万 - 项目类别:
相似海外基金
The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
- 批准号:
EP/Z000920/1 - 财政年份:2025
- 资助金额:
$ 23.7万 - 项目类别:
Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
- 批准号:
FT230100276 - 财政年份:2024
- 资助金额:
$ 23.7万 - 项目类别:
ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
- 批准号:
MR/X024261/1 - 财政年份:2024
- 资助金额:
$ 23.7万 - 项目类别:
Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
- 批准号:
DE240100388 - 财政年份:2024
- 资助金额:
$ 23.7万 - 项目类别:
Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
- 批准号:
2889694 - 财政年份:2023
- 资助金额:
$ 23.7万 - 项目类别:
Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
- 批准号:
2842926 - 财政年份:2023
- 资助金额:
$ 23.7万 - 项目类别:
Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
- 批准号:
NC/X001644/1 - 财政年份:2023
- 资助金额:
$ 23.7万 - 项目类别:
Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
- 批准号:
2337595 - 财政年份:2023
- 资助金额:
$ 23.7万 - 项目类别:
Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
- 批准号:
2232190 - 财政年份:2023
- 资助金额:
$ 23.7万 - 项目类别:
Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
- 批准号:
23K17514 - 财政年份:2023
- 资助金额:
$ 23.7万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)