Histology/Imaging Core C

组织学/成像核心C项目总结 克利夫兰DDRCC组织学/成像核心的总体目标是提供高质量的 实验动物模型和人胃肠道中胃肠道和肝脏系统的形态学分析 和肝脏相关的病理。此外，组织学/成像核心的主要目标是支持新的和 凯斯西储大学（CWRU）和克利夫兰诊所基金会的研究人员 (CCF)，没有直接专注于消化系统疾病相关研究的人，进入这个令人兴奋的领域， 调查，并鼓励在消化领域工作的DDRCC成员之间的合作 炎症和新陈代谢。组织学/成像核心继续致力于提供基础和 基础组织学，病理学解释和半定量评分，以及 免疫组织化学（IHC）和免疫荧光（IF）方法对GI和肝脏相关 研究，同时实施最先进的技术，如数字病理学和小 DDRCC研究者临床前和临床研究的动物成像。重要的是，组织学/成像核心 人员将提供宝贵的专家咨询，促进核心技术的培训和转让 DDRCC研究人员及其实验室成员，以加强CWRU的GI和肝脏相关研究项目 和CCF。DDRCC组织学/成像核心的具体目标是：1）提供组织学分析， 2）提供免疫组织化学（IHC）和/或免疫荧光（IF）染色; 3)提供小动物成像; 4）提供数字病理学、图像分析和照片记录，以及5） 提供咨询、教育、培训和提供存档组织。通过这些目标，克利夫兰 DDRCC组织学/成像核心将促进在消化系统疾病的高质量研究的生产， 成本效益和时间效率的方式，并提高消化研究的速度，深度和广度 CWRU和CCF期间的炎症/肿瘤发生和肝脏疾病/代谢，导致 在这一重要研究领域的科学发现的进步。

HISTOLOGY/IMAGING CORE C PROJECT SUMMARY The overall objective of the Histology/Imaging Core of the Cleveland DDRCC is to provide high-quality morphologic analyses of the gastrointestinal and liver systems in experimental animal models and human GI and liver-related pathologies. In addition, a major goal of the Histology/Imaging Core is to support new and established investigators at Case Western Reserve University (CWRU) and the Cleveland Clinic Foundation (CCF), who do not have a direct focus on digestive disease-related research, to enter this exciting field of investigation and to encourage collaborations among DDRCC members working in the areas of digestive inflammation and metabolism. The Histology/Imaging Core continues to be committed to provide basic and fundamental histology, with pathology interpretation and semi-quantitative scoring, as well as immunohistochemical (IHC) and immunofluorescence (IF) methodologies essential to GI- and liver-related research, while at the same time implementing state-of-the-art technologies, such as digital pathology and small animal imaging of DDRCC investigators’ preclinical and clinical studies. Importantly, Histology/Imaging Core personnel will provide valuable expert consultation and facilitate the training and transfer of Core technologies to DDRCC investigators and their lab members to enhance GI- and liver-related research programs at CWRU and CCF. The specific aims for the DDRCC Histology/Imaging Core are: 1) Provide histological analysis and scoring of GI & liver diseases; 2) Provide immunohistochemistry (IHC) and/or immunofluorescence (IF) staining; 3) Provide small animal imaging; 4) Provide digital pathology, image analysis, and photodocumentation, and 5) Provide consultation, education, training, and provision of archival tissues. Through these aims, the Cleveland DDRCC Histology/Imaging Core will facilitate the production of high-quality research in digestive diseases in a cost-effective and time-efficient manner, and enhance the rate, depth, and breadth of research in Digestive Inflammation/Tumorigenesis and Liver Disease/Metabolism throughout CWRU and CCF, leading to advancement of scientific discoveries in this important field of investigation.