Research Core

研究核心

• 批准号: 10557581
• 负责人: Jose Lugo-Martinez
• 金额: $ 32.24万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557581
• 关键词: Acceleration; Address; Adoption; Area; Artificial Intelligence; Basic Science; Big Data; Bioinformatics; Biological; Biomedical Research; Biometry; Biostatistics Core; Cancer health equity; Clinical Research; Collaborations; Collection; Communities; Complement; Computational Biology; Data; Data Analyses; Data Collection; Data Science; Databases; Development; Education; Evaluation; Experimental Designs; Faculty; Future; Generations; Genomics; Goals; Grant; Hispanic; Information Services; Infrastructure; Institution; Investments; Journals; Knowledge; Libraries; Machine Learning; Maintenance; Malignant Neoplasms; Manuscripts; Methodology; Outcome; Peer Review; Pilot Projects; Play; Population Research; Predictive Analytics; Predictive Value; Publications; Publishing; Puerto Rico; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Role; Semantics; Services; Software Tools; Solid; Statistical Data Interpretation; System; Terminology; Training; Training and Infrastructure; Translational Research; Universities; analytical method; anticancer research; application programming interface; bioinformatics pipeline; computer infrastructure; computerized data processing; computerized tools; data management; data quality; data repository; data resource; data sharing; genomic data; high throughput analysis; improved; information model; interest; learning strategy; machine learning prediction; multiple datasets; next generation sequencing; novel; population based; programs; research and development; syntax; tool

PROJECT SUMMARY/ABSTRACT: BIOINFORMATICS AND BIOSTATISTICS (BBC) RESEARCH CORE The Center for the Promotion of Cancer Health Equity (CePCHE) is to provide centralized management, support, specialized technical services, and evaluation for advancing investigators, and creating a sustained integrated basic research development and support center. To accomplish this aim, the CePCHE will establish a much- needed Bioinformatics and Biostatistics Core (BBC) to strengthen and improve the University of Puerto Rico’s (UPR) limited infrastructure in cancer research. The goal of the BBC is to serve as an expert hub to address bioinformatics and biostatistics for the CePCHE’s Research Projects Leaders (RPLs) as well as pipeline and early-stage investigators invested in cancer research. To accomplish this goal, the BBC has established the following specific aims: (1) To implementation, data analysis, provide biostatistical assistance and support for study design methodology, and interpretation of biomedical data; (2) Provide bioinformatics support in predictive analytics (artificial intelligence and machine learning), and computational support (software tools and application programming interfaces or APIs); (3) Establish a computational infrastructure suitable for big-data analyses, and data repository for data collection, curation, annotation, management, and storage of primary and secondary databases; and (4) Establish and strengthen working relationships and a training portfolio of the BBC with other IDeA institutions. Additionally, the BBC will support and train RPLs and other promising junior investigators addressing the CePCHE’s theme in data processing, management, and analysis. The BBC will play a leading role in the creation, collection, and maintenance of a shared Data Repository to expand the immediate access of UPR faculty to these multiple data sets and resources. It is expected that the BBC will provide a solid infrastructure for CePCHE’s RPLs to expedite their research, publish results in a timely manner in high impact peer-reviewed journals, and prepare and submit competitive R-type proposals within three years of initiation of the CePCHE. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

项目概要/摘要：生物信息学和生物统计学（BBC）研究核心 促进癌症健康公平中心（CePCHE）将提供集中管理，支持， 专业技术服务和评价，以促进调查人员的发展，并建立一个持续的综合 基础研究发展和支持中心。为了实现这一目标，CePCHE将建立一个多- 需要生物信息学和生物统计学核心（BBC），以加强和改善波多黎各大学 Rico（UPR）在癌症研究方面的基础设施有限。英国广播公司的目标是作为一个专家中心， 为CePCHE的研究项目领导者（RPL）以及管道解决生物信息学和生物统计学问题 早期研究人员投资于癌症研究。为了实现这一目标，BBC建立了 具体目标：（1） 实施、数据分析 为研究设计方法提供生物统计学协助和支持， 生物医学数据的分析和解释;（2）提供生物信息学支持， 预测分析（人工智能和机器学习）和计算支持（软件工具和 应用程序编程接口或API）;（3）建立适合大数据的计算基础设施 分析和数据存储库，用于数据收集、策展、注释、管理和存储主要和 二级数据库;以及（4）建立和加强BBC的工作关系和培训组合 与其他IDEA机构。此外，英国广播公司将支持和培训RPL和其他有前途的初级 研究人员解决CePCHE的数据处理，管理和分析的主题。BBC将 在共享数据存储库的创建、收集和维护方面发挥主导作用，以扩展 普遍定期审议工作人员可以立即获得这些多个数据集和资源。预计BBC将 为CePCHE的RPL提供坚实的基础设施，以加快其研究，及时发布结果 在高影响力的同行评审期刊上发表，并在三年内准备和提交有竞争力的R型提案 启动CePCHE。 OMB编号0925-0001/0002（修订版03/2020批准至02/28/2023）页码继续格式页码