Genomic and Bioinformatic Core

基因组和生物信息学核心

• 批准号: 10556539
• 负责人: Christopher W Cowan
• 金额: $ 35.53万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556539
• 关键词: Algorithmic Analysis; Applications Grants; Artificial Intelligence; Bioinformatics; Biomedical Computing; Biometry; Cell Separation; Cells; Centers of Research Excellence; Cloud Computing; Code; Communities; Complex; Computer Systems; Computer software; Custom; Data; Data Analyses; Data Collection; Data Science; Data Set; Disease; Environment; Equity; Experimental Designs; Fee-for-Service Plans; Future; Gene Expression Profiling; Genomic approach; Genomics; Goals; Image Analysis; Infrastructure; Interdisciplinary Study; Language; Leadership; Mentors; Mentorship; Modernization; Pilot Projects; Preparation; Programming Languages; Publications; Quality Control; Research; Research Design; Research Personnel; Research Project Grants; Resources; Sampling; Technology; Training; Update; Vertebral column; analysis pipeline; biomedical scientist; code development; computer infrastructure; data acquisition; data analysis pipeline; data management; data sharing; data visualization; design; diverse data; epigenomics; experience; genetic analysis; genome sequencing; genomic data; high end computer; interest; member; multiple omics; neurodevelopment; next generation; next generation sequencing; novel; peer; peer coaching; repository; success; theories; transcriptomics; whole genome

GENOMIC AND BIOINFORMATIC CORE – PROJECT SUMMARY The Genomic and Bioinformatic Core (GBC) will provide CNDD investigators with the resources, support, and training necessary for both data analysis, data sharing, and data interpretation. The overall objective of the GBC is to enhance the success of the CNDD investigators through high-quality support in state-of-the- art bioinformatics, biostatistics, and data management for CNDD research projects and pilot projects through mentorship and training and analysis execution, which includes assistance with study design, implementation, data collection, analysis, data publication and sharing, and future grant proposals. The hardware backbone of GBC computing capacity is a cluster with 200 CPU cores and 2 GPU cores distributed over 3 nodes with 346 GB RAM each. The software backbone consists of a suite of scientific programming environments, as well as compilers for all major programming languages, and in-house analysis pipelines are available for standard NGS sequencing analysis and single-cell multiomics. The GBC will host a Git repository (GitLab) for software-version control and data sharing to assist the CNDD JIs and their trainees with bioinformatic data sharing. The GBC will assist CNDD JI success thru the following Specific Aims: 1) Provide CNDD investigators with essential computation infrastructure for complex genomic and bioinformatic research approaches; 2) Provide CNDD Investigators with expert technical staff to carry out complex bioinformatic analysis of genetic, transcriptomic, and epigenomic data sets; and 3) Train and mentor CNDD investigators, their trainees, and the broader MUSC research community, in cutting-edge, bioinformatic data analysis of genetic, transcriptomic, and epigenomic data sets.

基因组学和生物信息学核心-项目摘要 基因组和生物信息学核心（GBC）将为CNDD研究人员提供资源，支持， 以及数据分析、数据共享和数据解释所需的培训。的总体目标 GBC将通过高质量的支持来提高国家民主与发展委员会调查人员的成功率， 艺术生物信息学，生物统计学和数据管理的CNDD研究项目和试点项目，通过 指导、培训和分析执行，包括协助研究设计， 实施、数据收集、分析、数据公布和共享以及未来的赠款提案。的 GBC计算能力的硬件骨干是一个具有200个CPU核心和2个GPU核心的分布式集群 超过3个节点，每个节点具有346 GB RAM。软件主干由一套科学的程序设计组成 环境，以及所有主要编程语言的编译器和内部分析管道 可用于标准NGS测序分析和单细胞多组学。GBC将托管Git 用于软件版本控制和数据共享的数据库（GitLab），以协助国家民主与发展委员会联合执行机构及其受训人员 生物信息学数据共享。GBC将通过以下具体目标协助国家民主与发展委员会联合执行取得成功： 为CNDD研究人员提供复杂基因组和生物信息学的基本计算基础设施 2）为国家民主与发展委员会的调查人员提供专家技术人员，以开展复杂的研究工作; 遗传、转录组和表观基因组数据集的生物信息学分析;以及3）训练和指导CNDD 研究人员，他们的学员，以及更广泛的MUSC研究社区，在尖端，生物信息学数据 分析遗传、转录组和表观基因组数据集。