COBRE in Neurodevelopment and Its Disorders

COBRE 在神经发育及其疾病中的作用

• 批准号: 10556537
• 负责人: Christopher W Cowan
• 金额: $ 223.28万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556537
• 关键词: Animal Model; Animals; Area; Attention deficit hyperactivity disorder; Basic Science; Behavioral; Bioinformatics; Biological Markers; Biology; Brain; Brain imaging; Centers of Research Excellence; Child; Clinical; Clinical Research; Collaborations; Communities; Complement; Department chair; Development; Diagnosis; Disease; Environment; Epilepsy; Equipment; Evaluation; Explosion; Faculty; Fostering; Functional disorder; Funding; Future; Gene Expression; Genetic; Genomics; Goals; Grant; Health; Human; Image; Imaging technology; Impaired cognition; Individual; Institution; Intellectual functioning disability; Interdisciplinary Study; Investments; Leadership; Link; Medical; Medicine; Mentors; Mission; Modernization; Molecular; Molecular Neurobiology; Mus; Neurodevelopmental Disability; Neurodevelopmental Disorder; Neurosciences Research; Pathology; Peer Review; Personal Satisfaction; Phenotype; Pilot Projects; Psychologist; Publications; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Scientist; Source; South Carolina; Symptoms; Systems Development; Technology; Training; Translational Research; Traumatic injury; United States National Institutes of Health; Universities; Vision; Writing; autism spectrum disorder; behavioral phenotyping; biomarker discovery; brain research; career; career development; cell type; college; computer infrastructure; disorder risk; economic cost; experience; human model; improved; in vivo; individuals with autism spectrum disorder; innovation; member; multidisciplinary; neural; neurodevelopment; new growth; novel; novel therapeutic intervention; programs; recruit; social; success; synergism; training opportunity

OVERALL – PROJECT SUMMARY The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its Disorders (CNDD) is to enhance research capacity by enabling outstanding multidisciplinary collaborative research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC). This area is of importance to the state of South Carolina as the diagnosis rate and proportion of individuals with Autism Spectrum Disorder (ASD) who have significant cognitive impairments is estimated to be higher than those of the nation. The specific aims are to: 1) Mentor a strong cadre of early career scientists to become independently funded investigators in NDD research; 2) Establish sustainable core resources to support modern NDD research while leveraging institutional investments; and 3) Promote sustainability of the CNDD through creation of multidisciplinary research programs, rigorous evaluation, strategic improvement, and mission alignment with other Centers at MUSC and across the state of South Carolina. The Center is led by a multidisciplinary team, composed of a department chair with extensive experience in molecular neurobiology, an expert in the field of complement biology, and a clinical psychologist focused on ASD research within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of building a critical mass of funded investigators that will allow MUSC to compete for future external peer-reviewed programmatic grant support. This application highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. We anticipate each of these JIs to transition to independent NIH funding within the first three years of the project. The CNDD also includes three Cores that will support not only the JIs but also NDD investigators throughout MUSC. Scientific cores include the: 1) Genomic and Bioinformatic Core, which will provide technical assistance, computational infrastructure, and training opportunities; 2) Mouse Behavioral Phenotyping Core, which will provide access to and training in behavioral analyses of mice; and 3) Small Animal Brain Imaging Core, which will provide access to modern brain imaging technologies that can extend the scope and impact of neurodevelopment research. Additionally, the CNDD will foster collaborations among NDD researchers by promoting interdisciplinary scientific exchange through our enrichment activities and build research capabilities through our Pilot Project Program. With NIH and institutional support, the expansion of research capabilities, development of JIs, and promotion of integrative, multidisciplinary NDD research programs, the proposed CNDD will substantially enhance basic, translational, and clinical research at MUSC. Together with key institutional investments across the state, the CNDD will enable the formation of a sustainable, thriving hub of world-class research in neurodevelopment and its disorders in South Carolina.

总体而言——项目概要 The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its 疾病（CNDD）旨在通过实现杰出的多学科协作来增强研究能力 research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC).这个区域 is of importance to the state of South Carolina as the diagnosis rate and proportion of individuals with Autism Spectrum Disorder (ASD) who have significant cognitive impairments is estimated to be higher than those of the 国家。具体目标是： 1）指导一批早期职业科学家成为独立的科学家 资助 NDD 研究的研究者； 2) Establish sustainable core resources to support modern NDD research 同时利用机构投资； 3) 通过创建 CNDD 的可持续性 multidisciplinary research programs, rigorous evaluation, strategic improvement, and mission alignment with MUSC 和南卡罗来纳州的其他中心。该中心由多学科团队领导， 由在分子神经生物学领域具有丰富经验的系主任、该领域的专家组成 补充生物学，以及 MUSC 医学院专注于 ASD 研究的临床心理学家， coalescing resources to achieve their overarching objective of building a critical mass of funded investigators that will allow MUSC to compete for future external peer-reviewed programmatic grant support.这个应用程序 highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors.我们预计这些 JI 中的每一个 在项目的前三年内过渡到独立的 NIH 资助。 CNDD 还包括三个 核心不仅支持 JI，还支持整个 MUSC 的 NDD 调查员。科学核心包括 1) 基因组和生物信息学核心，将提供技术援助、计算基础设施、 和培训机会； 2) Mouse Behavioral Phenotyping Core, which will provide access to and training in 小鼠行为分析； 3) 小动物脑成像核心，它将提供现代大脑的通道 成像技术可以扩大神经发育研究的范围和影响。此外， CNDD 将通过促进跨学科科学交流来促进 NDD 研究人员之间的合作 通过我们的丰富活动并通过我们的试点项目计划建立研究能力。与美国国立卫生研究院 和机构支持、研究能力的扩展、联合研究的发展以及综合性的促进， 多学科 NDD 研究计划，拟议的 CNDD 将大大加强基础、转化、 以及 MUSC 的临床研究。 CNDD 将与全州的主要机构投资一起 形成一个可持续、繁荣的世界级神经发育及其疾病研究中心 南卡罗来纳州。