COBRE in Neurodevelopment and Its Disorders

COBRE 在神经发育及其疾病中的作用

• 批准号: 10556537
• 负责人: Christopher W Cowan
• 金额: $ 223.28万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556537
• 关键词: Animal Model; Animals; Area; Attention deficit hyperactivity disorder; Basic Science; Behavioral; Bioinformatics; Biological Markers; Biology; Brain; Brain imaging; Centers of Research Excellence; Child; Clinical; Clinical Research; Collaborations; Communities; Complement; Department chair; Development; Diagnosis; Disease; Environment; Epilepsy; Equipment; Evaluation; Explosion; Faculty; Fostering; Functional disorder; Funding; Future; Gene Expression; Genetic; Genomics; Goals; Grant; Health; Human; Image; Imaging technology; Impaired cognition; Individual; Institution; Intellectual functioning disability; Interdisciplinary Study; Investments; Leadership; Link; Medical; Medicine; Mentors; Mission; Modernization; Molecular; Molecular Neurobiology; Mus; Neurodevelopmental Disability; Neurodevelopmental Disorder; Neurosciences Research; Pathology; Peer Review; Personal Satisfaction; Phenotype; Pilot Projects; Psychologist; Publications; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Scientist; Source; South Carolina; Symptoms; Systems Development; Technology; Training; Translational Research; Traumatic injury; United States National Institutes of Health; Universities; Vision; Writing; autism spectrum disorder; behavioral phenotyping; biomarker discovery; brain research; career; career development; cell type; college; computer infrastructure; disorder risk; economic cost; experience; human model; improved; in vivo; individuals with autism spectrum disorder; innovation; member; multidisciplinary; neural; neurodevelopment; new growth; novel; novel therapeutic intervention; programs; recruit; social; success; synergism; training opportunity

OVERALL – PROJECT SUMMARY The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its Disorders (CNDD) is to enhance research capacity by enabling outstanding multidisciplinary collaborative research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC). This area is of importance to the state of South Carolina as the diagnosis rate and proportion of individuals with Autism Spectrum Disorder (ASD) who have significant cognitive impairments is estimated to be higher than those of the nation. The specific aims are to: 1) Mentor a strong cadre of early career scientists to become independently funded investigators in NDD research; 2) Establish sustainable core resources to support modern NDD research while leveraging institutional investments; and 3) Promote sustainability of the CNDD through creation of multidisciplinary research programs, rigorous evaluation, strategic improvement, and mission alignment with other Centers at MUSC and across the state of South Carolina. The Center is led by a multidisciplinary team, composed of a department chair with extensive experience in molecular neurobiology, an expert in the field of complement biology, and a clinical psychologist focused on ASD research within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of building a critical mass of funded investigators that will allow MUSC to compete for future external peer-reviewed programmatic grant support. This application highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. We anticipate each of these JIs to transition to independent NIH funding within the first three years of the project. The CNDD also includes three Cores that will support not only the JIs but also NDD investigators throughout MUSC. Scientific cores include the: 1) Genomic and Bioinformatic Core, which will provide technical assistance, computational infrastructure, and training opportunities; 2) Mouse Behavioral Phenotyping Core, which will provide access to and training in behavioral analyses of mice; and 3) Small Animal Brain Imaging Core, which will provide access to modern brain imaging technologies that can extend the scope and impact of neurodevelopment research. Additionally, the CNDD will foster collaborations among NDD researchers by promoting interdisciplinary scientific exchange through our enrichment activities and build research capabilities through our Pilot Project Program. With NIH and institutional support, the expansion of research capabilities, development of JIs, and promotion of integrative, multidisciplinary NDD research programs, the proposed CNDD will substantially enhance basic, translational, and clinical research at MUSC. Together with key institutional investments across the state, the CNDD will enable the formation of a sustainable, thriving hub of world-class research in neurodevelopment and its disorders in South Carolina.

总体--项目摘要 生物医学卓越研究中心(COBRE)在神经发育方面的总体目标及其 障碍(CNDD)旨在通过实现卓越的多学科协作来增强研究能力 南卡罗来纳医科大学神经发育障碍(NDD)研究。这一地区 对南卡罗来纳州来说很重要，因为自闭症患者的诊断率和比例 据估计，有严重认知障碍的谱系障碍(ASD)患者比 国家。具体目标是：1)指导一支强大的早期职业科学家干部队伍，使他们独立成长 资助NDD研究人员；2)建立可持续的核心资源，支持现代NDD研究 同时利用机构投资；以及3)通过建立 多学科研究计划、严格评估、战略改进以及与 南加州大学和南卡罗来纳州的其他中心。该中心由一个多学科团队领导， 由一位在分子神经生物学方面有丰富经验的系主任组成，一位 补体生物学，以及MUSC医学院专注于ASD研究的临床心理学家， 整合资源以实现其总体目标，即建立一支足够多的资助调查人员 这将使MUSC能够竞争未来的外部同行审查的方案赠款支持。此应用程序 重点介绍我们四位最优秀的初级调查员(JIS)，他们将受益于创新的多重 以内部和外部导师为特色的来源指导计划。我们预计这些联合调查组中的每一个都将 在该项目的头三年内过渡到独立的NIH资金。CNDD还包括三个 这些核心不仅将支持联合检查组，而且还将支持整个南加州大学的NDD调查人员。科学核心包括 1)基因组和生物信息学核心，将提供技术援助、计算基础设施、 和培训机会；2)小鼠行为表型核心，它将提供访问和培训 小鼠的行为分析；以及3)小动物脑成像核心，它将提供进入现代大脑的途径 可以扩展神经发育研究的范围和影响的成像技术。此外， CNDD将通过促进跨学科科学交流促进NDD研究人员之间的合作 通过我们的丰富活动，并通过我们的试点项目计划建立研究能力。与NIH合作 和机构支持，扩大研究能力，开发联合信息系统，促进综合、 多学科NDD研究计划，拟议的CNDD将大大增强基础、翻译、 以及在南加州大学的临床研究。与全州的关键机构投资一起，CNDD将使 形成一个可持续的、蓬勃发展的世界级神经发育及其障碍研究中心 南卡罗来纳州。