COBRE in Neurodevelopment and Its Disorders

COBRE 在神经发育及其疾病中的作用

• 批准号: 10556537
• 负责人: Christopher W Cowan
• 金额: $ 223.28万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556537
• 关键词: Animal Model; Animals; Area; Attention deficit hyperactivity disorder; Basic Science; Behavioral; Bioinformatics; Biological Markers; Biology; Brain; Brain imaging; Centers of Research Excellence; Child; Clinical; Clinical Research; Collaborations; Communities; Complement; Department chair; Development; Diagnosis; Disease; Environment; Epilepsy; Equipment; Evaluation; Explosion; Faculty; Fostering; Functional disorder; Funding; Future; Gene Expression; Genetic; Genomics; Goals; Grant; Health; Human; Image; Imaging technology; Impaired cognition; Individual; Institution; Intellectual functioning disability; Interdisciplinary Study; Investments; Leadership; Link; Medical; Medicine; Mentors; Mission; Modernization; Molecular; Molecular Neurobiology; Mus; Neurodevelopmental Disability; Neurodevelopmental Disorder; Neurosciences Research; Pathology; Peer Review; Personal Satisfaction; Phenotype; Pilot Projects; Psychologist; Publications; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Scientist; Source; South Carolina; Symptoms; Systems Development; Technology; Training; Translational Research; Traumatic injury; United States National Institutes of Health; Universities; Vision; Writing; autism spectrum disorder; behavioral phenotyping; biomarker discovery; brain research; career; career development; cell type; college; computer infrastructure; disorder risk; economic cost; experience; human model; improved; in vivo; individuals with autism spectrum disorder; innovation; member; multidisciplinary; neural; neurodevelopment; new growth; novel; novel therapeutic intervention; programs; recruit; social; success; synergism; training opportunity

OVERALL – PROJECT SUMMARY The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its Disorders (CNDD) is to enhance research capacity by enabling outstanding multidisciplinary collaborative research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC). This area is of importance to the state of South Carolina as the diagnosis rate and proportion of individuals with Autism Spectrum Disorder (ASD) who have significant cognitive impairments is estimated to be higher than those of the nation. The specific aims are to: 1) Mentor a strong cadre of early career scientists to become independently funded investigators in NDD research; 2) Establish sustainable core resources to support modern NDD research while leveraging institutional investments; and 3) Promote sustainability of the CNDD through creation of multidisciplinary research programs, rigorous evaluation, strategic improvement, and mission alignment with other Centers at MUSC and across the state of South Carolina. The Center is led by a multidisciplinary team, composed of a department chair with extensive experience in molecular neurobiology, an expert in the field of complement biology, and a clinical psychologist focused on ASD research within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of building a critical mass of funded investigators that will allow MUSC to compete for future external peer-reviewed programmatic grant support. This application highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. We anticipate each of these JIs to transition to independent NIH funding within the first three years of the project. The CNDD also includes three Cores that will support not only the JIs but also NDD investigators throughout MUSC. Scientific cores include the: 1) Genomic and Bioinformatic Core, which will provide technical assistance, computational infrastructure, and training opportunities; 2) Mouse Behavioral Phenotyping Core, which will provide access to and training in behavioral analyses of mice; and 3) Small Animal Brain Imaging Core, which will provide access to modern brain imaging technologies that can extend the scope and impact of neurodevelopment research. Additionally, the CNDD will foster collaborations among NDD researchers by promoting interdisciplinary scientific exchange through our enrichment activities and build research capabilities through our Pilot Project Program. With NIH and institutional support, the expansion of research capabilities, development of JIs, and promotion of integrative, multidisciplinary NDD research programs, the proposed CNDD will substantially enhance basic, translational, and clinical research at MUSC. Together with key institutional investments across the state, the CNDD will enable the formation of a sustainable, thriving hub of world-class research in neurodevelopment and its disorders in South Carolina.

总体 - 项目摘要 生物医学研究中心卓越中心（Cobre）的总体目标 疾病（CNDD）是通过启用出色的多学科合作来增强研究能力 南卡罗来纳州医科大学（MUSC）的神经发育障碍研究（NDD）。这个区域 对南卡罗来纳州作为自闭症患者的诊断率和比例是重要的 估计具有重大认知障碍的频谱障碍（ASD）高于 国家。具体目的是：1）指导强大的早期职业科学家干部，以独立成为 NDD研究的资助研究人员； 2）建立可持续的核心资源来支持现代NDD研究 在利用机构投资的同时； 3）通过创建CNDD的可持续性 多学科研究计划，严格的评估，战略改进以及任务一致性 其他中心在MUSC和整个南卡罗来纳州。该中心由一个多学科团队领导， 由拥有分子神经生物学经验丰富经验的部门主席组成，该领域的专家 补充生物学和临床心理学家专注于MUSC医学院的ASD研究， 合并资源以实现他们建立大量资助的研究人员的总体目标 这将使MUSC能够竞争未来的外部同行评审计划赠款支持。此应用程序 亮点我们最杰出的初级调查员（JIS），他们将从创新的倍数中受益 来源的心理计划，具有内部和外部精神。我们期望这些JIS中的每一个 在项目的前三年内过渡到独立NIH资金。 CNDD还包括三个 不仅支持JIS，而且还支持整个MUSC的NDD调查人员的核心。科学核心包括 ：1）基因组和生物信息学核心，它将提供技术援助，计算基础架构， 和培训机会； 2）鼠标行为表型核心，该核心将在 小鼠的行为分析； 3）小型动物脑成像核心，该核心将提供现代大脑的通道 可以扩大神经发育研究范围和影响的成像技术。另外， CNDD将通过促进跨学科科学交流来促进NDD研究人员之间的合作 通过我们的丰富活动并通过我们的试点项目计划来建立研究能力。与NIH 和机构支持，研究能力的扩展，JIS的发展以及促进综合的促进， 多学科NDD研究计划，拟议的CNDD将大大增强基本，翻译， 和MUSC的临床研究。与全州的主要机构投资一起，CNDD将启用 在神经发育领域的世界一流研究中的可持续，蓬勃发展的枢纽及其疾病的形成 南卡罗来纳州。