COBRE in Neurodevelopment and Its Disorders
COBRE 在神经发育及其疾病中的作用
基本信息
- 批准号:10556537
- 负责人:
- 金额:$ 223.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-01 至 2028-02-29
- 项目状态:未结题
- 来源:
- 关键词:Animal ModelAnimalsAreaAttention deficit hyperactivity disorderBasic ScienceBehavioralBioinformaticsBiological MarkersBiologyBrainBrain imagingCenters of Research ExcellenceChildClinicalClinical ResearchCollaborationsCommunitiesComplementDepartment chairDevelopmentDiagnosisDiseaseEnvironmentEpilepsyEquipmentEvaluationExplosionFacultyFosteringFunctional disorderFundingFutureGene ExpressionGeneticGenomicsGoalsGrantHealthHumanImageImaging technologyImpaired cognitionIndividualInstitutionIntellectual functioning disabilityInterdisciplinary StudyInvestmentsLeadershipLinkMedicalMedicineMentorsMissionModernizationMolecularMolecular NeurobiologyMusNeurodevelopmental DisabilityNeurodevelopmental DisorderNeurosciences ResearchPathologyPeer ReviewPersonal SatisfactionPhenotypePilot ProjectsPsychologistPublicationsResearchResearch InfrastructureResearch PersonnelResearch TrainingResourcesScientistSourceSouth CarolinaSymptomsSystems DevelopmentTechnologyTrainingTranslational ResearchTraumatic injuryUnited States National Institutes of HealthUniversitiesVisionWritingautism spectrum disorderbehavioral phenotypingbiomarker discoverybrain researchcareercareer developmentcell typecollegecomputer infrastructuredisorder riskeconomic costexperiencehuman modelimprovedin vivoindividuals with autism spectrum disorderinnovationmembermultidisciplinaryneuralneurodevelopmentnew growthnovelnovel therapeutic interventionprogramsrecruitsocialsuccesssynergismtraining opportunity
项目摘要
OVERALL – PROJECT SUMMARY
The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its
Disorders (CNDD) is to enhance research capacity by enabling outstanding multidisciplinary collaborative
research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC). This area
is of importance to the state of South Carolina as the diagnosis rate and proportion of individuals with Autism
Spectrum Disorder (ASD) who have significant cognitive impairments is estimated to be higher than those of the
nation. The specific aims are to: 1) Mentor a strong cadre of early career scientists to become independently
funded investigators in NDD research; 2) Establish sustainable core resources to support modern NDD research
while leveraging institutional investments; and 3) Promote sustainability of the CNDD through creation of
multidisciplinary research programs, rigorous evaluation, strategic improvement, and mission alignment with
other Centers at MUSC and across the state of South Carolina. The Center is led by a multidisciplinary team,
composed of a department chair with extensive experience in molecular neurobiology, an expert in the field of
complement biology, and a clinical psychologist focused on ASD research within the MUSC College of Medicine,
coalescing resources to achieve their overarching objective of building a critical mass of funded investigators
that will allow MUSC to compete for future external peer-reviewed programmatic grant support. This application
highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple
source mentoring plan which features both internal and external mentors. We anticipate each of these JIs to
transition to independent NIH funding within the first three years of the project. The CNDD also includes three
Cores that will support not only the JIs but also NDD investigators throughout MUSC. Scientific cores include
the: 1) Genomic and Bioinformatic Core, which will provide technical assistance, computational infrastructure,
and training opportunities; 2) Mouse Behavioral Phenotyping Core, which will provide access to and training in
behavioral analyses of mice; and 3) Small Animal Brain Imaging Core, which will provide access to modern brain
imaging technologies that can extend the scope and impact of neurodevelopment research. Additionally, the
CNDD will foster collaborations among NDD researchers by promoting interdisciplinary scientific exchange
through our enrichment activities and build research capabilities through our Pilot Project Program. With NIH
and institutional support, the expansion of research capabilities, development of JIs, and promotion of integrative,
multidisciplinary NDD research programs, the proposed CNDD will substantially enhance basic, translational,
and clinical research at MUSC. Together with key institutional investments across the state, the CNDD will enable
the formation of a sustainable, thriving hub of world-class research in neurodevelopment and its disorders in
South Carolina.
总体-项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Christopher W Cowan其他文献
Christopher W Cowan的其他文献
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{{ truncateString('Christopher W Cowan', 18)}}的其他基金
COCA: Project 1. Drug-induced ROS and Epigenetic Mechanisms
COCA:项目 1. 药物诱导的 ROS 和表观遗传机制
- 批准号:
10404584 - 财政年份:2019
- 资助金额:
$ 223.28万 - 项目类别:
COCA: Project 1. Drug-induced ROS and Epigenetic Mechanisms
COCA:项目 1. 药物诱导的 ROS 和表观遗传机制
- 批准号:
10630228 - 财政年份:2019
- 资助金额:
$ 223.28万 - 项目类别:
Role and regulation of class IIa HDACs in cocaine addiction
IIa 类 HDAC 在可卡因成瘾中的作用和调节
- 批准号:
8676763 - 财政年份:2013
- 资助金额:
$ 223.28万 - 项目类别:
Role and regulation of class IIa HDACs in cocaine addiction
IIa 类 HDAC 在可卡因成瘾中的作用和调节
- 批准号:
8874183 - 财政年份:2013
- 资助金额:
$ 223.28万 - 项目类别:
Role and regulation of class IIa HDACs in cocaine addiction
IIa 类 HDAC 在可卡因成瘾中的作用和调节
- 批准号:
8575636 - 财政年份:2013
- 资助金额:
$ 223.28万 - 项目类别:
Role of Class IIa HDAC Target Genes in Opioid and Cocaine Addiction
IIa 类 HDAC 靶基因在阿片类药物和可卡因成瘾中的作用
- 批准号:
10401908 - 财政年份:2013
- 资助金额:
$ 223.28万 - 项目类别:
Role and regulation of class IIa HDACs in cocaine addiction
IIa 类 HDAC 在可卡因成瘾中的作用和调节
- 批准号:
9333284 - 财政年份:2013
- 资助金额:
$ 223.28万 - 项目类别:
Role of FMRP in Cocaine-Dependent Behavioral Plasticity
FMRP 在可卡因依赖性行为可塑性中的作用
- 批准号:
8606280 - 财政年份:2011
- 资助金额:
$ 223.28万 - 项目类别:
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