COBRE in Neurodevelopment and Its Disorders

COBRE 在神经发育及其疾病中的作用

• 批准号: 10556537
• 负责人: Christopher W Cowan
• 金额: $ 223.28万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10556537
• 关键词: Animal Model; Animals; Area; Attention deficit hyperactivity disorder; Basic Science; Behavioral; Bioinformatics; Biological Markers; Biology; Brain; Brain imaging; Centers of Research Excellence; Child; Clinical; Clinical Research; Collaborations; Communities; Complement; Department chair; Development; Diagnosis; Disease; Environment; Epilepsy; Equipment; Evaluation; Explosion; Faculty; Fostering; Functional disorder; Funding; Future; Gene Expression; Genetic; Genomics; Goals; Grant; Health; Human; Image; Imaging technology; Impaired cognition; Individual; Institution; Intellectual functioning disability; Interdisciplinary Study; Investments; Leadership; Link; Medical; Medicine; Mentors; Mission; Modernization; Molecular; Molecular Neurobiology; Mus; Neurodevelopmental Disability; Neurodevelopmental Disorder; Neurosciences Research; Pathology; Peer Review; Personal Satisfaction; Phenotype; Pilot Projects; Psychologist; Publications; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Scientist; Source; South Carolina; Symptoms; Systems Development; Technology; Training; Translational Research; Traumatic injury; United States National Institutes of Health; Universities; Vision; Writing; autism spectrum disorder; behavioral phenotyping; biomarker discovery; brain research; career; career development; cell type; college; computer infrastructure; disorder risk; economic cost; experience; human model; improved; in vivo; individuals with autism spectrum disorder; innovation; member; multidisciplinary; neural; neurodevelopment; new growth; novel; novel therapeutic intervention; programs; recruit; social; success; synergism; training opportunity

OVERALL – PROJECT SUMMARY The overall goal of the Center of Biomedical Research Excellence (COBRE) in Neurodevelopment and Its Disorders (CNDD) is to enhance research capacity by enabling outstanding multidisciplinary collaborative research in neurodevelopmental disorders (NDD) at the Medical University of South Carolina (MUSC). This area is of importance to the state of South Carolina as the diagnosis rate and proportion of individuals with Autism Spectrum Disorder (ASD) who have significant cognitive impairments is estimated to be higher than those of the nation. The specific aims are to: 1) Mentor a strong cadre of early career scientists to become independently funded investigators in NDD research; 2) Establish sustainable core resources to support modern NDD research while leveraging institutional investments; and 3) Promote sustainability of the CNDD through creation of multidisciplinary research programs, rigorous evaluation, strategic improvement, and mission alignment with other Centers at MUSC and across the state of South Carolina. The Center is led by a multidisciplinary team, composed of a department chair with extensive experience in molecular neurobiology, an expert in the field of complement biology, and a clinical psychologist focused on ASD research within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of building a critical mass of funded investigators that will allow MUSC to compete for future external peer-reviewed programmatic grant support. This application highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. We anticipate each of these JIs to transition to independent NIH funding within the first three years of the project. The CNDD also includes three Cores that will support not only the JIs but also NDD investigators throughout MUSC. Scientific cores include the: 1) Genomic and Bioinformatic Core, which will provide technical assistance, computational infrastructure, and training opportunities; 2) Mouse Behavioral Phenotyping Core, which will provide access to and training in behavioral analyses of mice; and 3) Small Animal Brain Imaging Core, which will provide access to modern brain imaging technologies that can extend the scope and impact of neurodevelopment research. Additionally, the CNDD will foster collaborations among NDD researchers by promoting interdisciplinary scientific exchange through our enrichment activities and build research capabilities through our Pilot Project Program. With NIH and institutional support, the expansion of research capabilities, development of JIs, and promotion of integrative, multidisciplinary NDD research programs, the proposed CNDD will substantially enhance basic, translational, and clinical research at MUSC. Together with key institutional investments across the state, the CNDD will enable the formation of a sustainable, thriving hub of world-class research in neurodevelopment and its disorders in South Carolina.

总体-项目摘要 生物医学研究卓越中心（COBRE）在神经发育及其 疾病（CNDD）是通过使杰出的多学科合作， 南卡罗来纳州医科大学（MUSC）的神经发育障碍（NDD）研究。这一领域 对于南卡罗来纳州来说，自闭症的诊断率和比例非常重要。 据估计，患有严重认知障碍的谱系障碍（ASD）患者的患病率高于患有 民族具体目标是：1）指导一个强大的早期职业科学家干部成为独立的 资助NDD研究的研究人员; 2）建立可持续的核心资源，支持现代NDD研究 同时利用机构投资;以及3）通过创建 多学科的研究计划，严格的评估，战略改进，和使命与 其他中心在MUSC和整个南卡罗来纳州。该中心由一个多学科小组领导， 由一位在分子神经生物学方面具有丰富经验的系主任， 补充生物学，和临床心理学家专注于ASD研究在MUSC医学院， 整合资源，以实现其总体目标，即培养足够数量的有经费的调查员 这将使MUSC能够竞争未来的外部同行评审计划赠款支持。本申请 突出了我们四个最优秀的初级研究员（JIs）谁将受益于创新的多重 包括内部和外部导师的源指导计划。我们预计这些JI中的每一个都将 在项目的前三年内过渡到独立的NIH资助。CNDD还包括三个 不仅支持JI，而且支持整个MUSC的NDD调查员的核心。科学核心包括 1）基因组和生物信息学核心，将提供技术援助，计算基础设施， 和培训机会; 2）小鼠行为表型核心，将提供以下方面的访问和培训： 小鼠的行为分析;以及3）小动物脑成像核心，其将提供对现代大脑的访问 成像技术可以扩大神经发育研究的范围和影响。另夕h CNDD将通过促进跨学科科学交流，促进NDD研究人员之间的合作 通过我们的丰富活动，并通过我们的试点项目计划建立研究能力。与NIH 和机构支持，扩大研究能力，发展联合研究所，促进综合， 多学科NDD研究计划，拟议的CNDD将大大提高基础，翻译， 和临床研究。与全州的主要机构投资一起，CNDD将使 形成一个可持续的，蓬勃发展的世界级神经发育及其疾病研究中心， 南卡罗来纳州。