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Stress and Health in American Indian Pregnancies

美洲印第安人怀孕期间的压力与健康

基本信息

批准号：
10596992
负责人：
Andrew David Williams
金额：
$ 27.92万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-03-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10596992
关键词：
Acculturation Address Adult Age American Heart Association American Indians Biological Birth Breast Feeding Cardiovascular Diseases Cardiovascular system Centers of Research Excellence Child Chronic stress Communities Data Development Dose Enrollment Epidemiology Ethnic Population Event Exposure to Future Gestational Diabetes Goals Growth Hair Health Hydrocortisone Hypertension Indigenous Individual Infant Intervention Investigation Life Linear Regressions Link Logistic Regressions Longevity Low Birth Weight Infant Maternal Health Maternal and Child Health Measurement Measures Mediating Mediator Medical Medical Records Mental Health Mentors Methods Morbidity - disease rate Mothers North Dakota Pathway interactions Population Postpartum Period Pregnancy Premature Birth Premature Mortality Prospective, cohort study Psychosocial Factor Reporting Research Research Project Grants Risk Risk Factors Role Sampling Small for Gestational Age Infant Stress Substance abuse problem Surveys Testing Time Trauma Trauma Research United States Violence Woman adverse childhood events aged cardiometabolic risk cardiovascular disorder risk cardiovascular health cardiovascular risk factor career childhood adversity cohort feeding follow-up health disparity hypothalamic-pituitary-adrenal axis infant outcome intergenerational maternal outcome mortality novel obstetric outcomes pediatric trauma pregnancy disorder pregnant prenatal racial population resilience research response social transmission process traumatic event tribal community

项目摘要

Project Summary/Abstract Cardiovascular disease is the leading cause of mortality among American Indian populations, and cardiovascular-related premature mortality among this population is worsening. Between 2000 and 2015, cardiovascular disease mortality rates among American Indian individuals aged 25-49 years increased by up to 2.1%, yet declined or plateaued among similarly aged individuals in other racial/ethnic groups in the U.S. The American Heart Association recently called for intergenerational examinations of consequences of chronic stress, such as childhood adversity and trauma, on cardiovascular risk factors among infants and children. American Indian populations have been exposed to historic trauma through violence, forced relocation and forced acculturation. Additionally, American Indian populations are exposed to higher levels of Adverse Childhood Experiences (ACEs) than other racial/ethnic groups in the United States. Infant growth is a recognized risk factor for cardiovascular disease in adulthood, yet the relationship between maternal adverse childhood experiences and infant growth among American Indian populations is unexamined. Investigation of the effect of chronic stress on maternal hypothalamic-pituitary-adrenal axis function and maternal and obstetric outcomes is important, as these mechanisms may lie on the pathway between chronic stress and infant growth. The Stress and Health in American Indian Pregnancies (SHAIP) study aligns with the goals of the Indigenous Trauma and Resiliency Research Center by partnering with American Indian communities in culturally relevant research. The SHAIP study will enroll 375 pregnant American Indian women from 3 tribal communities in North Dakota, collecting detailed biologic, medical, and social data 1 time during pregnancy, at birth, at 6 months postpartum and at 12 months postpartum. In Aim 1, we will assess the association between maternal ACEs and maternal hair cortisol concentration during pregnancy. In Aim 2, we will test the hypothesis that maternal hair cortisol concentration mediates the association between maternal ACEs and maternal and obstetric outcomes. Lastly, in Aim 3, we will examine multiple mediators of the relationship between maternal ACEs and infant growth. This proposed research project will allow me to examine, for the first time, potential pathways between maternal ACEs and infant growth. Potentially modifiable mediators like breastfeeding and maternal health may inform culturally informed interventions targeting American Indian populations in North Dakota. Achieving the Specific Aims of this project will enable me to establish myself as a leading scholar in the intergenerational transmission of maternal ACEs and cardiometabolic risk factors among infants.

项目总结/文摘