Cerebrospinal fluid (CSF) and peripheral markers of the neuropsychiatric sequelae of COVID-19: The Generation C-SF pregnancy study
COVID-19 神经精神后遗症的脑脊液 (CSF) 和外周标志物:C-SF 一代妊娠研究
基本信息
- 批准号:10595028
- 负责人:
- 金额:$ 84.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2027-01-31
- 项目状态:未结题
- 来源:
- 关键词:2019-nCoVAcuteAgeAntibodiesAttentionAutoantibodiesAutoimmune ProcessBloodBlood specimenCOVID-19Central Nervous SystemCerebrospinal FluidCognitionCognitiveCognitive deficitsCohort StudiesDataDevelopmentDiagnosticDimensionsExclusionExposure toFundingGeneral PopulationGenerationsGoalsImmunoassayImmunoglobulin GImpaired cognitionInfectionInflammationInflammatoryLinkLong-Term EffectsLongitudinal StudiesMeasuresMediatingMediatorMemoryMental HealthNeuronsNew YorkNucleocapsidOutcomePerformancePeripheralPhenotypePostpartum DepressionPostpartum PeriodPostpartum WomenPregnancyPregnant WomenProcessRisk FactorsRoleSARS-CoV-2 antibodySARS-CoV-2 exposureSARS-CoV-2 infectionSamplingVaccinationVulnerable PopulationsWomancognitive performancecognitive testingcohortexecutive functionfetalhigh riskinflammatory markerlong term consequences of COVID-19neuropsychiatric sequelae of COVID-19neuropsychiatric symptomneuropsychiatrypathogenpersonalized medicinepost SARS-CoV-2 infectionpostpartum outcomepsychiatric symptomreproductive
项目摘要
A large proportion of pregnant women worldwide (21% in our CDC-funded Generation C cohort, current
n=2,545) has been recently exposed to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
and women of reproductive age continue to be infected despite widespread vaccination. However, the acute
and subacute effects of SARS-CoV-2 infection during the vulnerable period of pregnancy and postpartum are
not yet clear. Pregnancy and the postpartum are high-risk periods for coronavirus disease 19 (COVID-19) and
for developing neuropsychiatric symptoms. Infections and dysregulation of inflammatory processes in the
periphery and central nervous system (CNS) are thought to play a role in this vulnerability. We now know that
SARS-CoV-2 causes high rates of subacute and long-term psychiatric and cognitive sequelae in the general
population. There is a need to also understand the long-term effects of SARS-CoV-2 infection on mental health
and cognition in the vulnerable population of pregnant and postpartum women, especially because they often
are excluded from large cohort studies. We propose to study the long-term effects of prior SARS-CoV-2
infection on psychiatric and cognitive sequelae postpartum, with a mediating role of central and peripheral
inflammation. We will leverage a well-powered pregnancy cohort (Generation C cohort, target n>3,000)
established in April 2020 in New York, with 21% of the cohort previously exposed to SARS-CoV-2
infection to date. In a subset of this cohort (n=500), we propose to collect paired blood and cerebrospinal
fluid (CSF) samples, which will provide the unique opportunity to investigate the subacute and long-term
impacts of SARS-CoV-2 infection on inflammatory processes in the central nervous system (CNS). We
hypothesize that prior SARS-CoV-2 infection can lead to dysregulation of peripheral and central inflammatory
processes during pregnancy, and that this contributes to causing psychiatric symptoms and cognitive
dysfunction in the vulnerable post-partum period. Aim 1 will characterize the subacute and long-term impact of
prior exposure to SARS-CoV-2 on central and peripheral inflammation in pregnant women, including
measuring SARS-CoV-2 IgG antibodies, characterizing inflammatory profiles using a high-sensitivity multiplex
immunoassay for 11 inflammatory markers in CSF and blood, and examining the presence of neuronal
autoantibodies. Aim 2 will examine the association between prior SARS-CoV-2 exposure, central and
peripheral inflammation during pregnancy, and psychiatric symptoms postpartum. Aim 3 will examine the
association between prior SARS-CoV-2 exposure, central and peripheral inflammation during pregnancy, and
cognitive deficits in attention, memory and executive functioning postpartum.
目前,全球有很大比例的孕妇(在我们cdc资助的C一代队列中占21%)
项目成果
期刊论文数量(0)
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Maria De Las Mercedes Perez Rodriguez其他文献
Maria De Las Mercedes Perez Rodriguez的其他文献
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{{ truncateString('Maria De Las Mercedes Perez Rodriguez', 18)}}的其他基金
Cerebrospinal fluid (CSF) and peripheral markers of the neuropsychiatric sequelae of COVID-19: The Generation C-SF pregnancy study
COVID-19 神经精神后遗症的脑脊液 (CSF) 和外周标志物:C-SF 一代妊娠研究
- 批准号:
10818133 - 财政年份:2023
- 资助金额:
$ 84.49万 - 项目类别:
Cerebrospinal fluid (CSF) and peripheral markers of the neuropsychiatric sequelae of COVID-19: The Generation C-SF pregnancy study
COVID-19 神经精神后遗症的脑脊液 (CSF) 和外周标志物:C-SF 一代妊娠研究
- 批准号:
10445499 - 财政年份:2022
- 资助金额:
$ 84.49万 - 项目类别:
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