Improving Treatment Engagement and Adherence to Optimize Outcomes for Opioid-Exposed Mother-Infant Dyads
Improving Treatment Engagement and Adherence to Optimize Outcomes for Opioid-Exposed Mother-Infant Dyads
批准号:
10595095
负责人:
Davida Schiff
金额:
$19.98万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
未结题
起止时间:
2019-04-01 至 2025-03-31
关键词:
AdherenceAdmission activityAdvisory CommitteesAffectAgeAmbulancesAreaAttitudeAwardBehavior TherapyBehavioralBeliefBiometryBuprenorphineCaringChildChild CareChild CustodyClinicClinical Trials DesignComplexConceptionsDataData SetDevelopmentDiscipline of obstetricsDoseFamilyFamily memberFeelingFemale of child bearing ageFentanylFutureGeneral PopulationGoalsHealthHeroinHormonal ChangeHospitalsInfantInterventionInterviewK-Series Research Career ProgramsLinkLive BirthManualsMassachusettsMaternal and Child HealthMedicalMedicineMentorshipMethadoneMethodsMothersNational Institute of Drug AbuseNeonatalOutcomeOverdosePerinatalPerinatal EpidemiologyPharmaceutical PreparationsPharmacotherapyPhysiciansPostpartum DepressionPostpartum PeriodPostpartum WomenPregnancyPregnancy RatePregnant WomenPrenatal carePrevalencePsychiatryPsychopathologyPsychotherapyPublic HealthQualitative ResearchRecommendationRecordsRecoveryRecovery SupportResearchResearch PersonnelResearch PriorityRiskRisk ReductionSeriesServicesShameStructureSymptomsTimeTrainingUnited StatesVulnerable PopulationsWomanWorkacceptability and feasibilityaddictionbarrier to carecareercomplex dataearly childhoodexperiencefield studyfollow-uphealth dataimprovedinfant outcomeintervention mappinglongitudinal analysismaternal outcomemedication compliancemultidisciplinaryopioid exposureopioid overdoseopioid use disorderopioid withdrawalpediatricianpilot testpregnancy associated deathprenatalprescription opioid misuseprogramspublic health emergencyrelapse riskreproductiveskillssocial stigmasubstance usetherapy developmenttreatment adherence
中文摘要
项目总结:
英文摘要
PROJECT SUMMARY:
The surge in the non-medical use of prescription opioids, heroin, and fentanyl is a critical public health
emergency affecting women of child bearing age and their families. Pregnancy can be a motivating time for
women with opioid use disorder (OUD) to engage in treatment, with pharmacotherapy (with methadone or
buprenorphine) and psychotherapy the recommended first line treatment. Pharmacotherapy adherence has
been associated with improved obstetric, infant, and maternal substance use outcomes at delivery. Yet
medication discontinuation in the postpartum period occurs at high rates, increasing the risk of relapse and
overdose. To date, however, interventions to support pharmacotherapy adherence among pregnant women
with OUD have shown mixed results, and few interventions have been aimed at postpartum women and
families. Therefore, the central objective of this mixed-methods study is to quantify how OUD pharmacotherapy
utilization impacts postpartum maternal-infant outcomes and qualitatively explore factors impacting treatment
adherence in order to develop a pharmacotherapy promotion intervention to improve the health of the opioid-
exposed mother-infant dyad. This project includes three main aims: (1) To analyze a linked, longitudinal,
administrative dataset from Massachusetts Department of Public Health to examine how duration of
pharmacotherapy engagement and type of pharmacotherapy received impact maternal and infant outcomes;
(2) To engage with a diverse group of stakeholders including postpartum women with opioid use disorder and
their families to qualitatively identify beliefs and attitudes and delineate interpersonal and structural barriers
and facilitators to treatment engagement and adherence to develop a pharmacotherapy promotion intervention;
and (3) Pilot test the pharmacotherapy intervention to improve treatment adherence among pregnant and
postpartum women with OUD assessing the feasibility and acceptability of the intervention. The findings from
this series of projects will fill an existing gap in a high priority research area within NIDA that will inform the
care of pregnant and postpartum women with OUD. The PI, Dr. Schiff, is an early-career clinician investigator,
pediatrician, and addiction medicine physician who will use this career development award to enhance her
skills in quantitative research including longitudinal analyses of complex public health datasets, qualitative
research with vulnerable populations, intervention development, and clinical trials design. Throughout the
award period, Dr. Schiff will work closely with a multidisciplinary mentorship and advisory team with expertise
in maternal-child health, addiction psychiatry, perinatal epidemiology, biostatistics, qualitative analysis,
intervention development, and clinical trials design to carry out her stated career objectives and specific aims.
期刊论文(11)
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DOI:
10.1542/peds.2021-052368
发表时间:
2022-03-01
期刊:
PEDIATRICS
影响因子:
8
作者:
[Schiff, Davida M., Work, Erin C., Foley, Bridget, Applewhite, Rachel, Diop, Hafsatou, Goullaud, Latisha, Gupta, Munish, Hoeppner, Bettina B., Peacock-Chambers, Elizabeth, Vilsaint, Corrie L., Bernstein, Judith A., Bryant, Allison S.]
通讯作者:
Bryant, Allison S.
DOI:
10.1016/j.ajogmf.2023.100963
发表时间:
2023
期刊:
American journal of obstetrics & gynecology MFM
影响因子:
6.3
作者:
[Siegel,MollyR, Cohen,SamuelJ, Koenigs,Kathleen, Woods,GregoryT, Schwartz,LeahN, Sarathy,Leela, Chou,JosephH, Terplan,Mishka, Wilens,Timothy, Ecker,JeffreyL, Bernstein,SarahN, Schiff,DavidaM]
通讯作者:
Schiff,DavidaM
Informed consent is poorly documented when obtaining toxicology testing at delivery in a Massachusetts cohort.
在马萨诸塞州队列中进行分娩时进行毒理学测试时,知情同意的记录很少。
DOI:
10.1016/j.ajogmf.2022.100621
发表时间:
2022
期刊:
American journal of obstetrics & gynecology MFM
影响因子:
6.3
作者:
[Koenigs,KathleenJ, Chou,JosephH, Cohen,Samuel, Nolan,Moira, Liu,Gina, Terplan,Mishka, Cummings,BrianM, Nielsen,Timothy, Smith,NicoleA, Distefano,Joseph, Bernstein,SarahN, Schiff,DavidaM]
通讯作者:
Schiff,DavidaM
Expansion and commentary on a two generation approach to prenatal opioid exposure - a commentary on Conradt et al. (2023).
对产前阿片类药物暴露的两代方法的扩展和评论 - Conradt 等人的评论。
DOI:
10.1111/jcpp.13770
发表时间:
2023
期刊:
Journal of child psychology and psychiatry, and allied disciplines
影响因子:
--
作者:
[Chaiyachati,BarbaraH, Schiff,Davida]
通讯作者:
Schiff,Davida
Risk of Severe Maternal Morbidity in Birthing People With Opioid Use Disorder.
患有阿片类药物使用障碍的新生儿出现严重孕产妇发病的风险。
DOI:
10.1016/j.whi.2023.06.002
发表时间:
2023
期刊:
Women's health issues : official publication of the Jacobs Institute of Women's Health
影响因子:
--
作者:
[Osei-Poku,GodwinK, Prentice,JuliaC, Peeler,Mary, Bernstein,SarahN, Iverson,RonaldE, Schiff,DavidaM]
通讯作者:
Schiff,DavidaM
共 9 条
Improving Treatment Engagement and Adherence to Optimize Outcomes for Opioid-Exposed Mother-Infant Dyads
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批准号:9894776
-
项目类别:
-
资助金额:$19.94万
-
财政年份:2019
-
负责人:Davida Schiff
-
依托单位:
Improving Treatment Engagement and Adherence to Optimize Outcomes for Opioid-Exposed Mother-Infant Dyads
-
批准号:10371095
-
项目类别:
-
资助金额:$19.98万
-
财政年份:2019
-
负责人:Davida Schiff
-
依托单位: