STATISTICAL ANALYSIS OF BIOMARKERS OF AGING

在几乎所有的国家都观察到了复杂的老化现象。 已经被研究过的多细胞生物 这样做的目的 一项提议是根据以下因素， 啮齿动物模型。 特别是，本提案响应了 进行全面的统计分析， 作为这项生物标志物的一部分， 老化研究RFA（NIH/NIA RFA AG-91-17），使用 数理统计、数学建模和高级科学 可视化技术允许统计，以及 科学/生物学上有效的老年年龄评估， 使用一组适用的 衰老的生物标志物 为了测试潜在策略的效果 和干预措施，对扩大的活力和生产力， 年的生命，重要的是，老化的可行生物标志物， 开发 衰老生物标志物的发展尤其重要， 重要的是，如果要制定科学的干预战略， 人类

The complex phenomenon of aging has been observed in nearly all multicellular organisms that have been studied. The purpose of this proposal is to produce a single panel of biomarkers of aging, based upon rodent animal models. In particular, this proposal responds to the request for a comprehensive statistical analysis designed to bring together the results of all of the research conducted as a part of this Biomarkers of Aging Research RFA (NIH/NIA RFA AG-91-17), using the procedures of mathematical statistics, mathematical modeling, and advanced scientific visualization techniques to permit a statistically, as well as scientifically/biologically valid assessment of the gerontologic age of rodents of the genotype specified in the RFA using a panel of applicable biomarkers of aging. In order to test the effects of potential strategies and interventions, on the extension of the vigorous and the productive years of life, it is important that viable biomarkers of aging be developed. The development of biomarkers of aging is particularly important if a scientific intervention strategy is to be developed for humans.