ADRENAL ANDROGEN PRODUCTION IN AGING
ADRENAL ANDROGEN PRODUCTION IN AGING
批准号:
2053562
负责人:
Charles RICHARD PARKER
金额:
$16.55万
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-05-01 至 1998-04-30
关键词:
adrenal glands adrenocorticotropic hormone aging androgens cortisol cytochrome P450 dexamethasone enzyme activity estradiol genetic transcription hormone regulation /control mechanism hormone therapy human genetic material tag human subject human tissue hydroxysteroid dehydrogenases immunocytochemistry in situ hybridization messenger RNA postmortem steroid hormone biosynthesis sulfotransferase
中文摘要
人类的衰老与肾上腺的显著不足有关。
脱氢表雄酮和脱氢表雄酮的生产
硫酸盐(DS)。DHA和DS的减少与增加相关
许多衰老后遗症的发生率,如心血管疾病。癌症
胰岛素抵抗。高脂血症和免疫能力受损。这个
DHA和DS肾上腺分泌减少的机制(S)是
未知和衰老对肾上腺分泌其他雄激素的影响
没有明确的定义。目前也不清楚男性的肾上腺功能是否
女性也同样会受到年龄的影响。基于之前的结果
研究肾上腺中的几种酶活性可能会在
衰老:7-羟基酶17,20-裂解酶,3β-羟基类固醇脱氢酶,和
类固醇磺基转移酶。我们建议确定老龄化对以下方面的影响
肾上腺类固醇生物合成途径的上述元件中的每一个
肾上腺对分级剂量ACTH反应的功能测试方法
无论是年轻的还是老年的男性和女性。我们还建议将数量量化
细胞色素P450(17α)、3β-羟基类固醇脱氢酶和
肾上腺标本中类固醇磺基转移酶及其mRNA的表达
对年轻和老年男性和女性的尸检。通过使用建议的
方法,我们希望能够表征由于老化引起的变化
在男性和女性中,以确定变化是否由于
特定肾上腺区域内的酶水平,并确定
这种变化很可能是由于基因转录发生了变化。这个
这些研究的结果应该为进一步研究提供良好的基础。
旨在预防或改善衰老对老年人的影响
人类的肾上腺。
英文摘要
Aging in humans is associated with a striking deficiency in adrenal
production of dehydroepiandrosterone (DHA) and dehydroepiandrosterone
sulfate (DS). Reductions in DHA and DS have been correlated with increased
incidence of many sequelae of aging such as cardiovascular disease. cancer
insulin resistance. hyperlipidemia and impaired immune competence. The
mechanism(s) responsible for reduced adrenal production of DHA and DS is
unknown and the impact of aging on adrenal production of other androgens
is not clearly defined. It also is unclear whether adrenal function in men
and women is similarly affected with aging. Based on the results of prior
studies several enzymatic activities in the adrenal may be altered during
aging: 7-hydroxylase 17, 20-lyase, 3beta-hydroxysteroid dehydrogenase, and
steroid sulfotransferase. We propose to determine the impact of aging on
each of the above elements of the adrenal steroid biosynthetic pathway by
means of functional testing of adrenal responses to graded doses of ACTH
in young and aged men and women. We also propose to quantify the amount
of cytochrome P450(17alpha), 3beta-hydroxysteroid dehydrogenase, and
steroid sulfotransferase and their mRNA's in adrenal specimens obtained at
autopsy of young and aged men and women. By use of the proposed
approaches, we expect to be able to characterize the changes due to aging
in men and women, to determine whether changes are due to alterations in
enzyme levels within particular adrenal zones, and to establish whether
such changes are likely to be due to altered gene transcription. The
results of these studies should provide a sound basis for further studies
directed toward prevention or amelioration of the effects of aging on the
human adrenal.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Rhesus-Human Adrenal Comparisons During Aging
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批准号:6439122
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项目类别:
-
资助金额:$7.24万
-
财政年份:2002
-
负责人:Charles RICHARD PARKER
-
依托单位:
ACTH SENSITIVITY/RESPONSIVITY IN AGING
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批准号:6274053
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项目类别:
-
资助金额:$2.59万
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财政年份:1998
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负责人:Charles RICHARD PARKER
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依托单位:
ACTH SENSITIVITY/RESPONSIVITY IN AGING
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批准号:6244029
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项目类别:
-
资助金额:$2.46万
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财政年份:1997
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负责人:Charles RICHARD PARKER
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依托单位:
ADRENAL ANDROGEN PRODUCTION IN AGING
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批准号:2413332
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项目类别:
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资助金额:$17.76万
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财政年份:1995
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负责人:Charles RICHARD PARKER
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依托单位:
ADRENAL ANDROGEN PRODUCTION IN AGING
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批准号:2053563
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项目类别:
-
资助金额:$17.17万
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财政年份:1995
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负责人:Charles RICHARD PARKER
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依托单位:
REPRODUCTIVE ENDOCRINOLOGY STUDY SECTION
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批准号:3555072
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项目类别:
-
资助金额:$9.25万
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财政年份:1988
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负责人:Charles RICHARD PARKER
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依托单位:
REPRODUCTIVE ENDOCRINOLOGY STUDY SECTION
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批准号:3555068
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项目类别:
-
资助金额:$8.0万
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财政年份:1988
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负责人:Charles RICHARD PARKER
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依托单位:
REPRODUCTIVE ENDOCRINOLOGY STUDY SECTION
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批准号:3555071
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项目类别:
-
资助金额:$0.31万
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财政年份:1988
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负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3322942
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项目类别:
-
资助金额:$13.44万
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财政年份:1986
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负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3322944
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项目类别:
-
资助金额:$4.51万
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财政年份:1986
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负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:2198722
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项目类别:
-
资助金额:$14.45万
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财政年份:1986
-
负责人:Charles RICHARD PARKER
-
依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3322941
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项目类别:
-
资助金额:$12.21万
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财政年份:1986
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负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3322943
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项目类别:
-
资助金额:$13.85万
-
财政年份:1986
-
负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3322940
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项目类别:
-
资助金额:$11.62万
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财政年份:1986
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负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3322936
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项目类别:
-
资助金额:$11.56万
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财政年份:1986
-
负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3322939
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项目类别:
-
资助金额:$2.2万
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财政年份:1986
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负责人:Charles RICHARD PARKER
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依托单位:
CONTROL OF LIPOPROTEIN AND STEROID LEVELS IN THE FETUS
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批准号:3312658
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项目类别:
-
资助金额:$7.18万
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财政年份:1980
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负责人:Charles RICHARD PARKER
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依托单位:
ACTH SENSITIVITY/RESPONSIVITY IN AGING
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批准号:5215698
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:Charles RICHARD PARKER
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依托单位:--
ACTH SENSITIVITY/RESPONSIVITY IN AGING
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批准号:6112819
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项目类别:
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资助金额:$3.06万
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财政年份:--
-
负责人:Charles RICHARD PARKER
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依托单位:
海外基金