ACTH SENSITIVITY/RESPONSIVITY IN AGING

衰老过程中 ACTH 的敏感性/反应性

• 批准号: 6274053
• 负责人: Charles RICHARD PARKER
• 金额: $ 2.59万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-26 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6274053
• 关键词: African American; adrenal disorder; adrenal glands; adrenocorticotropic hormone; age difference; aging; clinical research; human subject; steroid biosynthesis

Aging in humans is associated with a striking deficiency in adrenal production of androgens. Reduced levels of adrenal androgens have been correlated with increased indicence of many sequelae of aging such as cardiovascular disease, cancer, insulin resistance, hyperlipidemia, and impaired immune competence. The mechanisms for age-associated reductions in adrenal androgen production are unknown. It also is not clear if aging effects adrenal function in men and women in similar manners or whether there are race related differences in adrenal function in young or elderly humans. We propose to continue our studies on the effect of aging on the adrenal steroid biosynthetic pathway, particularly in aging African Americans, in whoem little is established regarding adrenal corticosteroid or androgen production. These studies will be condectted by means of dynamic functional testing of adrenal responses to graded doses of ACTH in aged men and women compared to young adults. The results of these studies are expected to provide both a characterization of adrenal function in aged adults and also to suggest the mechanisms whereby such function is altered in normal aging adults. The impact of hormone replacement therapy in postmenopausal women on adrenal steroidogenic responses also will be determined.

人类的衰老与肾上腺皮质激素的显著缺乏有关。 雄激素的产生。肾上腺雄激素水平降低 与许多衰老后遗症的增加有关， 心血管疾病、癌症、胰岛素抵抗、高脂血症，以及 免疫能力受损 与年龄相关的减少机制 在肾上腺雄激素产生中的作用是未知的。也不清楚衰老是否 影响男性和女性肾上腺功能的方式相似， 在年轻人和老年人中， 人类 我们建议继续研究老化对 肾上腺类固醇生物合成途径，特别是在非洲老龄化 美国人，他们对肾上腺皮质类固醇的认识很少 或雄激素的产生。 这些研究将通过以下方式进行： 肾上腺对不同剂量ACTH反应的动态功能测试 与年轻人相比，老年男性和女性。 这些研究的结果 预计将提供肾上腺功能的表征， 老年人，并提出这种功能的机制， 在正常的老年人中改变。 激素替代疗法的影响 在绝经后妇女中，肾上腺类固醇生成反应也将 测定